Structural and biochemical characterization of the exopolysaccharide deacetylase Agd3 required for Aspergillus fumigatus biofilm formation
The exopolysaccharide galactosaminogalactan (GAG) is an important virulence factor of the fungal pathogen Aspergillus fumigatus. Here, the authors study an A. fumigatus enzyme that deacetylates GAG in a metal-dependent manner and constitutes a founding member of a new carbohydrate esterase family.
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2020-05-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-16144-5 |
| _version_ | 1818694592294289408 |
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| author | Natalie C. Bamford François Le Mauff Jaime C. Van Loon Hanna Ostapska Brendan D. Snarr Yongzhen Zhang Elena N. Kitova John S. Klassen Jeroen D. C. Codée Donald C. Sheppard P. Lynne Howell |
| author_facet | Natalie C. Bamford François Le Mauff Jaime C. Van Loon Hanna Ostapska Brendan D. Snarr Yongzhen Zhang Elena N. Kitova John S. Klassen Jeroen D. C. Codée Donald C. Sheppard P. Lynne Howell |
| author_sort | Natalie C. Bamford |
| collection | DOAJ |
| description | The exopolysaccharide galactosaminogalactan (GAG) is an important virulence factor of the fungal pathogen Aspergillus fumigatus. Here, the authors study an A. fumigatus enzyme that deacetylates GAG in a metal-dependent manner and constitutes a founding member of a new carbohydrate esterase family. |
| first_indexed | 2024-12-17T13:32:02Z |
| format | Article |
| id | doaj.art-bc12a17a65694000bd265c5f6442da5e |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-17T13:32:02Z |
| publishDate | 2020-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-bc12a17a65694000bd265c5f6442da5e2022-12-21T21:46:33ZengNature PortfolioNature Communications2041-17232020-05-0111111310.1038/s41467-020-16144-5Structural and biochemical characterization of the exopolysaccharide deacetylase Agd3 required for Aspergillus fumigatus biofilm formationNatalie C. Bamford0François Le Mauff1Jaime C. Van Loon2Hanna Ostapska3Brendan D. Snarr4Yongzhen Zhang5Elena N. Kitova6John S. Klassen7Jeroen D. C. Codée8Donald C. Sheppard9P. Lynne Howell10Program in Molecular Medicine, The Hospital for Sick ChildrenDepartment of Microbiology and Immunology, Faculty of Medicine, McGill UniversityProgram in Molecular Medicine, The Hospital for Sick ChildrenDepartment of Microbiology and Immunology, Faculty of Medicine, McGill UniversityDepartment of Microbiology and Immunology, Faculty of Medicine, McGill UniversityLeiden Institute of Chemistry, Leiden UniversityAlberta Glycomics Centre and Department of Chemistry, University of AlbertaAlberta Glycomics Centre and Department of Chemistry, University of AlbertaLeiden Institute of Chemistry, Leiden UniversityDepartment of Microbiology and Immunology, Faculty of Medicine, McGill UniversityProgram in Molecular Medicine, The Hospital for Sick ChildrenThe exopolysaccharide galactosaminogalactan (GAG) is an important virulence factor of the fungal pathogen Aspergillus fumigatus. Here, the authors study an A. fumigatus enzyme that deacetylates GAG in a metal-dependent manner and constitutes a founding member of a new carbohydrate esterase family.https://doi.org/10.1038/s41467-020-16144-5 |
| spellingShingle | Natalie C. Bamford François Le Mauff Jaime C. Van Loon Hanna Ostapska Brendan D. Snarr Yongzhen Zhang Elena N. Kitova John S. Klassen Jeroen D. C. Codée Donald C. Sheppard P. Lynne Howell Structural and biochemical characterization of the exopolysaccharide deacetylase Agd3 required for Aspergillus fumigatus biofilm formation Nature Communications |
| title | Structural and biochemical characterization of the exopolysaccharide deacetylase Agd3 required for Aspergillus fumigatus biofilm formation |
| title_full | Structural and biochemical characterization of the exopolysaccharide deacetylase Agd3 required for Aspergillus fumigatus biofilm formation |
| title_fullStr | Structural and biochemical characterization of the exopolysaccharide deacetylase Agd3 required for Aspergillus fumigatus biofilm formation |
| title_full_unstemmed | Structural and biochemical characterization of the exopolysaccharide deacetylase Agd3 required for Aspergillus fumigatus biofilm formation |
| title_short | Structural and biochemical characterization of the exopolysaccharide deacetylase Agd3 required for Aspergillus fumigatus biofilm formation |
| title_sort | structural and biochemical characterization of the exopolysaccharide deacetylase agd3 required for aspergillus fumigatus biofilm formation |
| url | https://doi.org/10.1038/s41467-020-16144-5 |
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