Gemcabene, a First-in-Class Hypolipidemic Small Molecule in Clinical Development, Attenuates Osteoarthritis and Pain in Animal Models of Arthritis and Pain

Gemcabene, a First-in-Class Hypolipidemic Small Molecule in Clinical Development, Attenuates Osteoarthritis and Pain in Animal Models of Arthritis and Pain

Our clinical studies have demonstrated that gemcabene, a small molecule in late-stage clinical development, lowers pro-inflammatory acute-phase protein, C-reactive protein (CRP). This observation was further confirmed in a cell-based study showing inhibition of cytokine-induced CRP production. Based...

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Bibliographic Details
Main Authors: Rai A. K. Srivastava, Joseph A. Cornicelli, Bruce Markham, Charles L. Bisgaier
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Pharmacology
Subjects:
gemcabene
inflammation
CRP
IL6
IL-1β
NF-kB
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2018.00471/full

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