Unconventional conservation reveals structure-function relationships in the synaptonemal complex

Unconventional conservation reveals structure-function relationships in the synaptonemal complex

Functional requirements constrain protein evolution, commonly manifesting in a conserved amino acid sequence. Here, we extend this idea to secondary structural features by tracking their conservation in essential meiotic proteins with highly diverged sequences. The synaptonemal complex (SC) is a ~10...

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Bibliographic Details
Main Authors: Lisa E Kursel, Henry D Cope, Ofer Rog
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-11-01
Series:eLife
Subjects:
P. pacificus
meiosis
synaptonemal complex
coiled-coil
indel
evolution
Online Access:https://elifesciences.org/articles/72061

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