Clinical characteristics and prognosis of pediatric myelin oligodendrocyte glycoprotein antibody-associated diseases in China
Abstract Background Research on myelin oligodendrocyte glycoprotein antibody (MOG-Ab)-associated disease (MOGAD) among Chinese children is relatively rare. Therefore, this study aimed to explore and analyze the clinical characteristics and prognoses of Chinese children with acquired demyelinating sy...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2022-11-01
|
| Series: | BMC Pediatrics |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12887-022-03679-3 |
| _version_ | 1828127860414480384 |
|---|---|
| author | Xiaoang Sun Meiyan Liu Xiaona Luo Fang Yuan Chunmei Wang Simei Wang Quanmei Xu Yuanfeng Zhang Yucai Chen |
| author_facet | Xiaoang Sun Meiyan Liu Xiaona Luo Fang Yuan Chunmei Wang Simei Wang Quanmei Xu Yuanfeng Zhang Yucai Chen |
| author_sort | Xiaoang Sun |
| collection | DOAJ |
| description | Abstract Background Research on myelin oligodendrocyte glycoprotein antibody (MOG-Ab)-associated disease (MOGAD) among Chinese children is relatively rare. Therefore, this study aimed to explore and analyze the clinical characteristics and prognoses of Chinese children with acquired demyelinating syndromes (ADSs) who tested positive or negative for MOG-Ab. Methods The clinical data of children with MOGAD who were treated in the Department of Neurology at Shanghai Children's Hospital from January 2017 to October 2021 were retrospectively collected. Results Among 90 children with ADSs, 30 were MOG-Ab-positive, and 60 were MOG-Ab-negative. MOG-Ab-positive children experienced more prodromal infections than did MOG-Ab-negative children (P < 0.05). Acute disseminated encephalomyelitis was the most common ADSs in both groups. There were ten cases of a rebound increase in MOG-Ab titers. There were significant differences in the MOG titer-related prognosis and disease time course between the disease relapse group and the non-relapse group (P < 0.01). Among the MOG-Ab-positive patients, the most affected brain areas detected via magnetic resonance imaging (MRI) were the temporal lobe, cerebellar hemispheres, brainstem, and periventricular lesions. The most common shapes of the lesions were commas, triangles, or patches. The average improvement time based on brain MRI was much longer in MOG-Ab-positive than in MOG-Ab-negative children (P < 0.05). The initial treatment time correlated with the disease time course, and the prognosis may be affected by the disease time course and serum MOG-Ab titer (P < 0.05). Conclusion The clinical characteristics and imaging features of ADSs differed between MOG-Ab-positive and MOG-Ab-negative children. In addition to existing treatment plans, additional diagnoses and treatment plans should be developed to reduce recurrence and improve the prognoses of children with MOGAD. |
| first_indexed | 2024-04-11T15:56:07Z |
| format | Article |
| id | doaj.art-bc179294ba5c43348ef058f750af1964 |
| institution | Directory Open Access Journal |
| issn | 1471-2431 |
| language | English |
| last_indexed | 2024-04-11T15:56:07Z |
| publishDate | 2022-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pediatrics |
| spelling | doaj.art-bc179294ba5c43348ef058f750af19642022-12-22T04:15:10ZengBMCBMC Pediatrics1471-24312022-11-0122111210.1186/s12887-022-03679-3Clinical characteristics and prognosis of pediatric myelin oligodendrocyte glycoprotein antibody-associated diseases in ChinaXiaoang Sun0Meiyan Liu1Xiaona Luo2Fang Yuan3Chunmei Wang4Simei Wang5Quanmei Xu6Yuanfeng Zhang7Yucai Chen8Department of Neurology, Shanghai Children’s Hospital, School of medicine, Shanghai Jiao Tong UniversityDepartment of Neurology, Shanghai Children’s Hospital, School of medicine, Shanghai Jiao Tong UniversityDepartment of Neurology, Shanghai Children’s Hospital, School of medicine, Shanghai Jiao Tong UniversityDepartment of Neurology, Shanghai Children’s Hospital, School of medicine, Shanghai Jiao Tong UniversityDepartment of Neurology, Shanghai Children’s Hospital, School of medicine, Shanghai Jiao Tong UniversityDepartment of Neurology, Shanghai Children’s Hospital, School of medicine, Shanghai Jiao Tong UniversityDepartment of Neurology, Shanghai Children’s Hospital, School of medicine, Shanghai Jiao Tong UniversityDepartment of Neurology, Shanghai Children’s Hospital, School of medicine, Shanghai Jiao Tong UniversityDepartment of Neurology, Shanghai Children’s Hospital, School of medicine, Shanghai Jiao Tong UniversityAbstract Background Research on myelin oligodendrocyte glycoprotein antibody (MOG-Ab)-associated disease (MOGAD) among Chinese children is relatively rare. Therefore, this study aimed to explore and analyze the clinical characteristics and prognoses of Chinese children with acquired demyelinating syndromes (ADSs) who tested positive or negative for MOG-Ab. Methods The clinical data of children with MOGAD who were treated in the Department of Neurology at Shanghai Children's Hospital from January 2017 to October 2021 were retrospectively collected. Results Among 90 children with ADSs, 30 were MOG-Ab-positive, and 60 were MOG-Ab-negative. MOG-Ab-positive children experienced more prodromal infections than did MOG-Ab-negative children (P < 0.05). Acute disseminated encephalomyelitis was the most common ADSs in both groups. There were ten cases of a rebound increase in MOG-Ab titers. There were significant differences in the MOG titer-related prognosis and disease time course between the disease relapse group and the non-relapse group (P < 0.01). Among the MOG-Ab-positive patients, the most affected brain areas detected via magnetic resonance imaging (MRI) were the temporal lobe, cerebellar hemispheres, brainstem, and periventricular lesions. The most common shapes of the lesions were commas, triangles, or patches. The average improvement time based on brain MRI was much longer in MOG-Ab-positive than in MOG-Ab-negative children (P < 0.05). The initial treatment time correlated with the disease time course, and the prognosis may be affected by the disease time course and serum MOG-Ab titer (P < 0.05). Conclusion The clinical characteristics and imaging features of ADSs differed between MOG-Ab-positive and MOG-Ab-negative children. In addition to existing treatment plans, additional diagnoses and treatment plans should be developed to reduce recurrence and improve the prognoses of children with MOGAD.https://doi.org/10.1186/s12887-022-03679-3Myelin oligodendrocyte glycoprotein antibodyAcquired demyelinating syndromesClinical featuresPrognosisChildren |
| spellingShingle | Xiaoang Sun Meiyan Liu Xiaona Luo Fang Yuan Chunmei Wang Simei Wang Quanmei Xu Yuanfeng Zhang Yucai Chen Clinical characteristics and prognosis of pediatric myelin oligodendrocyte glycoprotein antibody-associated diseases in China BMC Pediatrics Myelin oligodendrocyte glycoprotein antibody Acquired demyelinating syndromes Clinical features Prognosis Children |
| title | Clinical characteristics and prognosis of pediatric myelin oligodendrocyte glycoprotein antibody-associated diseases in China |
| title_full | Clinical characteristics and prognosis of pediatric myelin oligodendrocyte glycoprotein antibody-associated diseases in China |
| title_fullStr | Clinical characteristics and prognosis of pediatric myelin oligodendrocyte glycoprotein antibody-associated diseases in China |
| title_full_unstemmed | Clinical characteristics and prognosis of pediatric myelin oligodendrocyte glycoprotein antibody-associated diseases in China |
| title_short | Clinical characteristics and prognosis of pediatric myelin oligodendrocyte glycoprotein antibody-associated diseases in China |
| title_sort | clinical characteristics and prognosis of pediatric myelin oligodendrocyte glycoprotein antibody associated diseases in china |
| topic | Myelin oligodendrocyte glycoprotein antibody Acquired demyelinating syndromes Clinical features Prognosis Children |
| url | https://doi.org/10.1186/s12887-022-03679-3 |
| work_keys_str_mv | AT xiaoangsun clinicalcharacteristicsandprognosisofpediatricmyelinoligodendrocyteglycoproteinantibodyassociateddiseasesinchina AT meiyanliu clinicalcharacteristicsandprognosisofpediatricmyelinoligodendrocyteglycoproteinantibodyassociateddiseasesinchina AT xiaonaluo clinicalcharacteristicsandprognosisofpediatricmyelinoligodendrocyteglycoproteinantibodyassociateddiseasesinchina AT fangyuan clinicalcharacteristicsandprognosisofpediatricmyelinoligodendrocyteglycoproteinantibodyassociateddiseasesinchina AT chunmeiwang clinicalcharacteristicsandprognosisofpediatricmyelinoligodendrocyteglycoproteinantibodyassociateddiseasesinchina AT simeiwang clinicalcharacteristicsandprognosisofpediatricmyelinoligodendrocyteglycoproteinantibodyassociateddiseasesinchina AT quanmeixu clinicalcharacteristicsandprognosisofpediatricmyelinoligodendrocyteglycoproteinantibodyassociateddiseasesinchina AT yuanfengzhang clinicalcharacteristicsandprognosisofpediatricmyelinoligodendrocyteglycoproteinantibodyassociateddiseasesinchina AT yucaichen clinicalcharacteristicsandprognosisofpediatricmyelinoligodendrocyteglycoproteinantibodyassociateddiseasesinchina |