Static Magnetic Fields Reduce Oxidative Stress to Improve Wound Healing and Alleviate Diabetic Complications
Although some studies have shown that some static magnetic fields (SMFs) can promote wound healing in diabetic mice, it is not clear whether the other diabetes complications, such as liver disease and diabetic nephropathy, can also be alleviated. Here, we constructed two simple magnetic plates using...
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MDPI AG
2022-01-01
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| Online Access: | https://www.mdpi.com/2073-4409/11/3/443 |
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| author | Chuanlin Feng Biao Yu Chao Song Junjun Wang Lei Zhang Xinmiao Ji Ying Wang Yanwen Fang Zhongcai Liao Min Wei Xin Zhang |
| author_facet | Chuanlin Feng Biao Yu Chao Song Junjun Wang Lei Zhang Xinmiao Ji Ying Wang Yanwen Fang Zhongcai Liao Min Wei Xin Zhang |
| author_sort | Chuanlin Feng |
| collection | DOAJ |
| description | Although some studies have shown that some static magnetic fields (SMFs) can promote wound healing in diabetic mice, it is not clear whether the other diabetes complications, such as liver disease and diabetic nephropathy, can also be alleviated. Here, we constructed two simple magnetic plates using neodymium permanent magnets to examine the comprehensive effects of moderate SMFs on genetically obese leptin receptor-deficient db/db diabetic mice. We found that although the blood glucose was not obviously reduced by these two SMF settings, both of the glycated serum protein (GSP) and malondialdehyde (MDA) levels were significantly decreased (Cohen’s d = 2.57–3.04). Moreover, the wound healing, liver lipid accumulation, and renal defects were all significantly improved by SMF treatment (Cohen’s d = 0.91–2.05). Wound tissue examination showed obvious nuclear factor erythroid 2-related factor 2 (NRF2) level decrease (Cohen’s d = 2.49–5.40) and Ki-67 level increase (Cohen’s d = 2.30–3.40), indicating decreased oxidative stress and increased cell proliferation. In vitro cellular studies with fibroblast NIH3T3 cells showed that SMFs could reduce high glucose-induced NRF2 nucleus translocation (Cohen’s d = 0.87–1.15) and cellular reactive oxygen species (ROS) elevation (Cohen’s d = 0.92), indicating decreased oxidative stress. Consequently, high glucose-induced impairments in cell vitality, proliferation, and migration were all improved by SMF treatment. Therefore, our results demonstrate that these simple SMF devices could effectively reduce oxidative stress in diabetic mice and may provide a cost-effective physical therapy strategy to alleviate multiple diabetic complications in the future. |
| first_indexed | 2024-03-10T00:03:35Z |
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| language | English |
| last_indexed | 2024-03-10T00:03:35Z |
| publishDate | 2022-01-01 |
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| series | Cells |
| spelling | doaj.art-bc184241ab944f2094946185160692b52023-11-23T16:11:57ZengMDPI AGCells2073-44092022-01-0111344310.3390/cells11030443Static Magnetic Fields Reduce Oxidative Stress to Improve Wound Healing and Alleviate Diabetic ComplicationsChuanlin Feng0Biao Yu1Chao Song2Junjun Wang3Lei Zhang4Xinmiao Ji5Ying Wang6Yanwen Fang7Zhongcai Liao8Min Wei9Xin Zhang10Institutes of Physical Science and Information Technology, Anhui University, Hefei 230039, ChinaHigh Magnetic Field Laboratory, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, ChinaHigh Magnetic Field Laboratory, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, ChinaHigh Magnetic Field Laboratory, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, ChinaHigh Magnetic Field Laboratory, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, ChinaHigh Magnetic Field Laboratory, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, ChinaHigh Magnetic Field Laboratory, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, ChinaHeye Health Technology Co., Ltd., Huzhou 313300, ChinaHeye Health Technology Co., Ltd., Huzhou 313300, ChinaHeye Health Technology Co., Ltd., Huzhou 313300, ChinaInstitutes of Physical Science and Information Technology, Anhui University, Hefei 230039, ChinaAlthough some studies have shown that some static magnetic fields (SMFs) can promote wound healing in diabetic mice, it is not clear whether the other diabetes complications, such as liver disease and diabetic nephropathy, can also be alleviated. Here, we constructed two simple magnetic plates using neodymium permanent magnets to examine the comprehensive effects of moderate SMFs on genetically obese leptin receptor-deficient db/db diabetic mice. We found that although the blood glucose was not obviously reduced by these two SMF settings, both of the glycated serum protein (GSP) and malondialdehyde (MDA) levels were significantly decreased (Cohen’s d = 2.57–3.04). Moreover, the wound healing, liver lipid accumulation, and renal defects were all significantly improved by SMF treatment (Cohen’s d = 0.91–2.05). Wound tissue examination showed obvious nuclear factor erythroid 2-related factor 2 (NRF2) level decrease (Cohen’s d = 2.49–5.40) and Ki-67 level increase (Cohen’s d = 2.30–3.40), indicating decreased oxidative stress and increased cell proliferation. In vitro cellular studies with fibroblast NIH3T3 cells showed that SMFs could reduce high glucose-induced NRF2 nucleus translocation (Cohen’s d = 0.87–1.15) and cellular reactive oxygen species (ROS) elevation (Cohen’s d = 0.92), indicating decreased oxidative stress. Consequently, high glucose-induced impairments in cell vitality, proliferation, and migration were all improved by SMF treatment. Therefore, our results demonstrate that these simple SMF devices could effectively reduce oxidative stress in diabetic mice and may provide a cost-effective physical therapy strategy to alleviate multiple diabetic complications in the future.https://www.mdpi.com/2073-4409/11/3/443static magnetic fieldsdiabetic wound healingoxidative stressNRF2physical therapy |
| spellingShingle | Chuanlin Feng Biao Yu Chao Song Junjun Wang Lei Zhang Xinmiao Ji Ying Wang Yanwen Fang Zhongcai Liao Min Wei Xin Zhang Static Magnetic Fields Reduce Oxidative Stress to Improve Wound Healing and Alleviate Diabetic Complications Cells static magnetic fields diabetic wound healing oxidative stress NRF2 physical therapy |
| title | Static Magnetic Fields Reduce Oxidative Stress to Improve Wound Healing and Alleviate Diabetic Complications |
| title_full | Static Magnetic Fields Reduce Oxidative Stress to Improve Wound Healing and Alleviate Diabetic Complications |
| title_fullStr | Static Magnetic Fields Reduce Oxidative Stress to Improve Wound Healing and Alleviate Diabetic Complications |
| title_full_unstemmed | Static Magnetic Fields Reduce Oxidative Stress to Improve Wound Healing and Alleviate Diabetic Complications |
| title_short | Static Magnetic Fields Reduce Oxidative Stress to Improve Wound Healing and Alleviate Diabetic Complications |
| title_sort | static magnetic fields reduce oxidative stress to improve wound healing and alleviate diabetic complications |
| topic | static magnetic fields diabetic wound healing oxidative stress NRF2 physical therapy |
| url | https://www.mdpi.com/2073-4409/11/3/443 |
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