Comparison of minimally invasive surfactant therapy with intubation surfactant administration and extubation for treating preterm infants with respiratory distress syndrome: a randomized clinical trial
Background Respiratory distress syndrome (RDS) is a common cause of hospitalization and death in preterm infants who require surfactant treatment and respiratory support. Purpose This study aimed to compare the clinical outcomes of minimally invasive surfactant therapy (MIST) and the INtubation, SUR...
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| Format: | Article |
| Language: | English |
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The Korean Pediatric Society
2022-04-01
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| Series: | Clinical and Experimental Pediatrics |
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| Online Access: | http://www.e-cep.org/upload/pdf/cep-2021-00297.pdf |
| _version_ | 1818309045980758016 |
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| author | Mohammad Kazem Sabzehei Behnaz Basiri Maryam Shokouhi Sajad Ghahremani Ali Moradi |
| author_facet | Mohammad Kazem Sabzehei Behnaz Basiri Maryam Shokouhi Sajad Ghahremani Ali Moradi |
| author_sort | Mohammad Kazem Sabzehei |
| collection | DOAJ |
| description | Background Respiratory distress syndrome (RDS) is a common cause of hospitalization and death in preterm infants who require surfactant treatment and respiratory support. Purpose This study aimed to compare the clinical outcomes of minimally invasive surfactant therapy (MIST) and the INtubation, SURfactant administration, and Extubation (INSURE) technique in preterm infants with RDS. Methods In this clinical trial, 112 preterm infants born at 28–36 weeks of gestation and diagnosed with RDS randomly received 200-mg/kg surfactant by MIST or the INSURE method. In the MIST group, surfactant was administered using a thin catheter (5F feeding tube); in the INSURE group, surfactant was administered after intubation using a feeding tube and the tracheal tube was removed after positive pressure ventilation was started. Nasal continuous positive airway pressure was applied in both groups for respiratory support and the postprocedure clinical outcomes were compared. Results The mean hospitalization time was shorter for infants in the MIST group than for those in the INSURE group (9.19± 1.72 days vs. 10.21±2.15 days, P=0.006). Patent ductus arteriosus was less frequent in the MIST group (14.3% vs. 30.4%, P=0.041). Desaturation during surfactant administration occurred less commonly in the MIST group (19.6% vs. 39.3%, P=0.023). There were no significant intergroup differences in other early or late complications. Conclusion These results suggest that surfactant administration using MIST could be a good replacement for INSURE in preterm infants with RDS since its use reduced the hospitalization time and the number of side effects. |
| first_indexed | 2024-12-13T07:23:56Z |
| format | Article |
| id | doaj.art-bc188a4bf11a418abfcf2ca2a4abee1d |
| institution | Directory Open Access Journal |
| issn | 2713-4148 |
| language | English |
| last_indexed | 2024-12-13T07:23:56Z |
| publishDate | 2022-04-01 |
| publisher | The Korean Pediatric Society |
| record_format | Article |
| series | Clinical and Experimental Pediatrics |
| spelling | doaj.art-bc188a4bf11a418abfcf2ca2a4abee1d2022-12-21T23:55:21ZengThe Korean Pediatric SocietyClinical and Experimental Pediatrics2713-41482022-04-0165418819310.3345/cep.2021.0029720125555454Comparison of minimally invasive surfactant therapy with intubation surfactant administration and extubation for treating preterm infants with respiratory distress syndrome: a randomized clinical trialMohammad Kazem Sabzehei0Behnaz Basiri1Maryam Shokouhi2Sajad Ghahremani3Ali Moradi4 Department of Pediatrics, Hamadan University of Medical Sciences, Hamadan, Iran Department of Pediatrics, Hamadan University of Medical Sciences, Hamadan, Iran Department of Pediatrics, Hamadan University of Medical Sciences, Hamadan, Iran Department of Pediatrics, Hamadan University of Medical Sciences, Hamadan, Iran Health Deputy, Hamadan University of Medical Sciences, Hamadan, IranBackground Respiratory distress syndrome (RDS) is a common cause of hospitalization and death in preterm infants who require surfactant treatment and respiratory support. Purpose This study aimed to compare the clinical outcomes of minimally invasive surfactant therapy (MIST) and the INtubation, SURfactant administration, and Extubation (INSURE) technique in preterm infants with RDS. Methods In this clinical trial, 112 preterm infants born at 28–36 weeks of gestation and diagnosed with RDS randomly received 200-mg/kg surfactant by MIST or the INSURE method. In the MIST group, surfactant was administered using a thin catheter (5F feeding tube); in the INSURE group, surfactant was administered after intubation using a feeding tube and the tracheal tube was removed after positive pressure ventilation was started. Nasal continuous positive airway pressure was applied in both groups for respiratory support and the postprocedure clinical outcomes were compared. Results The mean hospitalization time was shorter for infants in the MIST group than for those in the INSURE group (9.19± 1.72 days vs. 10.21±2.15 days, P=0.006). Patent ductus arteriosus was less frequent in the MIST group (14.3% vs. 30.4%, P=0.041). Desaturation during surfactant administration occurred less commonly in the MIST group (19.6% vs. 39.3%, P=0.023). There were no significant intergroup differences in other early or late complications. Conclusion These results suggest that surfactant administration using MIST could be a good replacement for INSURE in preterm infants with RDS since its use reduced the hospitalization time and the number of side effects.http://www.e-cep.org/upload/pdf/cep-2021-00297.pdfrespiratory distress syndromepreterm infantinsureminimally invasive surfactant therapy |
| spellingShingle | Mohammad Kazem Sabzehei Behnaz Basiri Maryam Shokouhi Sajad Ghahremani Ali Moradi Comparison of minimally invasive surfactant therapy with intubation surfactant administration and extubation for treating preterm infants with respiratory distress syndrome: a randomized clinical trial Clinical and Experimental Pediatrics respiratory distress syndrome preterm infant insure minimally invasive surfactant therapy |
| title | Comparison of minimally invasive surfactant therapy with intubation surfactant administration and extubation for treating preterm infants with respiratory distress syndrome: a randomized clinical trial |
| title_full | Comparison of minimally invasive surfactant therapy with intubation surfactant administration and extubation for treating preterm infants with respiratory distress syndrome: a randomized clinical trial |
| title_fullStr | Comparison of minimally invasive surfactant therapy with intubation surfactant administration and extubation for treating preterm infants with respiratory distress syndrome: a randomized clinical trial |
| title_full_unstemmed | Comparison of minimally invasive surfactant therapy with intubation surfactant administration and extubation for treating preterm infants with respiratory distress syndrome: a randomized clinical trial |
| title_short | Comparison of minimally invasive surfactant therapy with intubation surfactant administration and extubation for treating preterm infants with respiratory distress syndrome: a randomized clinical trial |
| title_sort | comparison of minimally invasive surfactant therapy with intubation surfactant administration and extubation for treating preterm infants with respiratory distress syndrome a randomized clinical trial |
| topic | respiratory distress syndrome preterm infant insure minimally invasive surfactant therapy |
| url | http://www.e-cep.org/upload/pdf/cep-2021-00297.pdf |
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