The epigenetic regulator CXXC finger protein 1 is essential for murine hematopoiesis.

The epigenetic regulator CXXC finger protein 1 is essential for murine hematopoiesis.

CXXC finger protein 1 (Cfp1), encoded by the Cxxc1 gene, binds to DNA sequences containing an unmethylated CpG dinucleotide and is an epigenetic regulator of both cytosine and histone methylation. Cxxc1-null mouse embryos fail to gastrulate, and Cxxc1-null embryonic stem cells are viable but cannot...

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Bibliographic Details
Main Authors: Kristin T Chun, Binghui Li, Erika Dobrota, Courtney Tate, Jeong-Heon Lee, Shehnaz Khan, Laura Haneline, Harm HogenEsch, David G Skalnik
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4254612?pdf=render

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