Life Entrapped in a Network of Atavistic Attractors: How to Find a Rescue
In view of unified cell bioenergetics, cell bioenergetic problems related to cell overenergization can cause excessive disturbances in current cell fate and, as a result, lead to a change of cell-fate. At the onset of the problem, cell overenergization of multicellular organisms (especially overener...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-04-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/7/4017 |
| _version_ | 1797438886185533440 |
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| author | Andrzej Kasperski |
| author_facet | Andrzej Kasperski |
| author_sort | Andrzej Kasperski |
| collection | DOAJ |
| description | In view of unified cell bioenergetics, cell bioenergetic problems related to cell overenergization can cause excessive disturbances in current cell fate and, as a result, lead to a change of cell-fate. At the onset of the problem, cell overenergization of multicellular organisms (especially overenergization of mitochondria) is solved inter alia by activation and then stimulation of the reversible Crabtree effect by cells. Unfortunately, this apparently good solution can also lead to a much bigger problem when, despite the activation of the Crabtree effect, cell overenergization persists for a long time. In such a case, cancer transformation, along with the Warburg effect, may occur to further reduce or stop the charging of mitochondria by high-energy molecules. Understanding the phenomena of cancer transformation and cancer development has become a real challenge for humanity. To date, many models have been developed to understand cancer-related mechanisms. Nowadays, combining all these models into one coherent universal model of cancer transformation and development can be considered a new challenge. In this light, the aim of this article is to present such a potentially universal model supported by a proposed new model of cellular functionality evolution. The methods of fighting cancer resulting from unified cell bioenergetics and the two presented models are also considered. |
| first_indexed | 2024-03-09T11:44:47Z |
| format | Article |
| id | doaj.art-bc198dc725a0486db8f3656f71704560 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T11:44:47Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-bc198dc725a0486db8f3656f717045602023-11-30T23:25:30ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-04-01237401710.3390/ijms23074017Life Entrapped in a Network of Atavistic Attractors: How to Find a RescueAndrzej Kasperski0Institute of Biological Sciences, Department of Biotechnology, Laboratory of Bioinformatics and Control of Bioprocesses, University of Zielona Góra, ul. Szafrana 1, 65-516 Zielona Góra, PolandIn view of unified cell bioenergetics, cell bioenergetic problems related to cell overenergization can cause excessive disturbances in current cell fate and, as a result, lead to a change of cell-fate. At the onset of the problem, cell overenergization of multicellular organisms (especially overenergization of mitochondria) is solved inter alia by activation and then stimulation of the reversible Crabtree effect by cells. Unfortunately, this apparently good solution can also lead to a much bigger problem when, despite the activation of the Crabtree effect, cell overenergization persists for a long time. In such a case, cancer transformation, along with the Warburg effect, may occur to further reduce or stop the charging of mitochondria by high-energy molecules. Understanding the phenomena of cancer transformation and cancer development has become a real challenge for humanity. To date, many models have been developed to understand cancer-related mechanisms. Nowadays, combining all these models into one coherent universal model of cancer transformation and development can be considered a new challenge. In this light, the aim of this article is to present such a potentially universal model supported by a proposed new model of cellular functionality evolution. The methods of fighting cancer resulting from unified cell bioenergetics and the two presented models are also considered.https://www.mdpi.com/1422-0067/23/7/4017aneuploidycancer genome instabilitycancer transformationCrabtree effectgenome chaosmtNADH molecules |
| spellingShingle | Andrzej Kasperski Life Entrapped in a Network of Atavistic Attractors: How to Find a Rescue International Journal of Molecular Sciences aneuploidy cancer genome instability cancer transformation Crabtree effect genome chaos mtNADH molecules |
| title | Life Entrapped in a Network of Atavistic Attractors: How to Find a Rescue |
| title_full | Life Entrapped in a Network of Atavistic Attractors: How to Find a Rescue |
| title_fullStr | Life Entrapped in a Network of Atavistic Attractors: How to Find a Rescue |
| title_full_unstemmed | Life Entrapped in a Network of Atavistic Attractors: How to Find a Rescue |
| title_short | Life Entrapped in a Network of Atavistic Attractors: How to Find a Rescue |
| title_sort | life entrapped in a network of atavistic attractors how to find a rescue |
| topic | aneuploidy cancer genome instability cancer transformation Crabtree effect genome chaos mtNADH molecules |
| url | https://www.mdpi.com/1422-0067/23/7/4017 |
| work_keys_str_mv | AT andrzejkasperski lifeentrappedinanetworkofatavisticattractorshowtofindarescue |