Structural dynamics of the active HER4 and HER2/HER4 complexes is finely tuned by different growth factors and glycosylation

Structural dynamics of the active HER4 and HER2/HER4 complexes is finely tuned by different growth factors and glycosylation

Human Epidermal growth factor Receptor 4 (HER4 or ERBB4) carries out essential functions in the development and maintenance of the cardiovascular and nervous systems. HER4 activation is regulated by a diverse group of extracellular ligands including the neuregulin (NRG) family and betacellulin (BTC)...

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Bibliographic Details
Main Authors: Raphael Trenker, Devan Diwanji, Tanner Bingham, Kliment A Verba, Natalia Jura
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2024-03-01
Series:eLife
Subjects:
receptor tyrosine kinases
membrane signaling
dimerization
growth factors
HER receptors
cancer biology
Online Access:https://elifesciences.org/articles/92873

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