<it>Mycobacterium avium </it>subspecies <it>paratuberculosis </it>is not associated with Type-2 Diabetes Mellitus
<p>Abstract</p> <p>Background</p> <p>The role of pathogenic mycobacteria in diabetes has been a focus of speculation since a decade without any meaningful insights into the mechanism of diabetes causation <it>vis a vis </it>mycobacterial factors. Two of our...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2008-04-01
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| Series: | Annals of Clinical Microbiology and Antimicrobials |
| Online Access: | http://www.ann-clinmicrob.com/content/7/1/9 |
| _version_ | 1818835449548898304 |
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| author | Zanetti Stefania Pacifico Adolfo Paccagnini Daniela Ahmed Niyaz Rosu Valentina Sechi Leonardo A |
| author_facet | Zanetti Stefania Pacifico Adolfo Paccagnini Daniela Ahmed Niyaz Rosu Valentina Sechi Leonardo A |
| author_sort | Zanetti Stefania |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>The role of pathogenic mycobacteria in diabetes has been a focus of speculation since a decade without any meaningful insights into the mechanism of diabetes causation <it>vis a vis </it>mycobacterial factors. Two of our studies based on PCR identification of mycobacterial DNA and detection of antibodies specific to the recombinant antigens and whole cell lysates of the <it>Mycobacterium avium </it>subsp. <it>paratuberculosis </it>(MAP) shown a clear association of MAP with the presence of type 1 diabetes mellitus (T1DM).</p> <p>Methods</p> <p>In this study, we sought to investigate if or not type 2 diabetes (T2DM) patients harbour humoral responses to MAP. Using three different MAP antigen preparations, humoral antibody profiles were estimated for 57 T2DM patients and 57 healthy controls. Statistical analysis was performed with the Chi-square test with Yates' corrections.</p> <p>Results</p> <p>We observed insignificant levels of humoral antibodies against recombinant heparin binding haemagglutinin (HbHA), glycosyl transferase (Gsd) and MAP whole cell lysate in the blood of subjects with T2DM as compared to healthy controls.</p> <p>Conclusion</p> <p>We found no obvious association of MAP with the incidence of T2DM in Sardinian patients.</p> |
| first_indexed | 2024-12-19T02:50:53Z |
| format | Article |
| id | doaj.art-bc1a4afbbaf14a85b2cf615bc40ae810 |
| institution | Directory Open Access Journal |
| issn | 1476-0711 |
| language | English |
| last_indexed | 2024-12-19T02:50:53Z |
| publishDate | 2008-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Annals of Clinical Microbiology and Antimicrobials |
| spelling | doaj.art-bc1a4afbbaf14a85b2cf615bc40ae8102022-12-21T20:38:40ZengBMCAnnals of Clinical Microbiology and Antimicrobials1476-07112008-04-0171910.1186/1476-0711-7-9<it>Mycobacterium avium </it>subspecies <it>paratuberculosis </it>is not associated with Type-2 Diabetes MellitusZanetti StefaniaPacifico AdolfoPaccagnini DanielaAhmed NiyazRosu ValentinaSechi Leonardo A<p>Abstract</p> <p>Background</p> <p>The role of pathogenic mycobacteria in diabetes has been a focus of speculation since a decade without any meaningful insights into the mechanism of diabetes causation <it>vis a vis </it>mycobacterial factors. Two of our studies based on PCR identification of mycobacterial DNA and detection of antibodies specific to the recombinant antigens and whole cell lysates of the <it>Mycobacterium avium </it>subsp. <it>paratuberculosis </it>(MAP) shown a clear association of MAP with the presence of type 1 diabetes mellitus (T1DM).</p> <p>Methods</p> <p>In this study, we sought to investigate if or not type 2 diabetes (T2DM) patients harbour humoral responses to MAP. Using three different MAP antigen preparations, humoral antibody profiles were estimated for 57 T2DM patients and 57 healthy controls. Statistical analysis was performed with the Chi-square test with Yates' corrections.</p> <p>Results</p> <p>We observed insignificant levels of humoral antibodies against recombinant heparin binding haemagglutinin (HbHA), glycosyl transferase (Gsd) and MAP whole cell lysate in the blood of subjects with T2DM as compared to healthy controls.</p> <p>Conclusion</p> <p>We found no obvious association of MAP with the incidence of T2DM in Sardinian patients.</p>http://www.ann-clinmicrob.com/content/7/1/9 |
| spellingShingle | Zanetti Stefania Pacifico Adolfo Paccagnini Daniela Ahmed Niyaz Rosu Valentina Sechi Leonardo A <it>Mycobacterium avium </it>subspecies <it>paratuberculosis </it>is not associated with Type-2 Diabetes Mellitus Annals of Clinical Microbiology and Antimicrobials |
| title | <it>Mycobacterium avium </it>subspecies <it>paratuberculosis </it>is not associated with Type-2 Diabetes Mellitus |
| title_full | <it>Mycobacterium avium </it>subspecies <it>paratuberculosis </it>is not associated with Type-2 Diabetes Mellitus |
| title_fullStr | <it>Mycobacterium avium </it>subspecies <it>paratuberculosis </it>is not associated with Type-2 Diabetes Mellitus |
| title_full_unstemmed | <it>Mycobacterium avium </it>subspecies <it>paratuberculosis </it>is not associated with Type-2 Diabetes Mellitus |
| title_short | <it>Mycobacterium avium </it>subspecies <it>paratuberculosis </it>is not associated with Type-2 Diabetes Mellitus |
| title_sort | it mycobacterium avium it subspecies it paratuberculosis it is not associated with type 2 diabetes mellitus |
| url | http://www.ann-clinmicrob.com/content/7/1/9 |
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