Current advances in niosomes applications for drug delivery and cancer treatment
The advent of nanotechnology has led to an increased interest in nanocarriers as a drug delivery system that is efficient and safe. There have been many studies addressing nano-scale vesicular systems such as liposomes and niosome is a newer generation of vesicular nanocarriers. The niosomes provide...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-12-01
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| Series: | Materials Today Bio |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590006423002971 |
| _version_ | 1797646407481425920 |
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| author | Ali Moammeri Masoumeh Mirzaei Chegeni Hamidreza Sahrayi Robabehbeygom Ghafelehbashi Farkhondeh Memarzadeh Afsoun Mansouri Iman Akbarzadeh Maryam Sadat Abtahi Faranak Hejabi Qun Ren |
| author_facet | Ali Moammeri Masoumeh Mirzaei Chegeni Hamidreza Sahrayi Robabehbeygom Ghafelehbashi Farkhondeh Memarzadeh Afsoun Mansouri Iman Akbarzadeh Maryam Sadat Abtahi Faranak Hejabi Qun Ren |
| author_sort | Ali Moammeri |
| collection | DOAJ |
| description | The advent of nanotechnology has led to an increased interest in nanocarriers as a drug delivery system that is efficient and safe. There have been many studies addressing nano-scale vesicular systems such as liposomes and niosome is a newer generation of vesicular nanocarriers. The niosomes provide a multilamellar carrier for lipophilic and hydrophilic bioactive substances in the self-assembled vesicle, which are composed of non-ionic surfactants in conjunction with cholesterol or other amphiphilic molecules. These non-ionic surfactant vesicles, simply known as niosomes, can be utilized in a wide variety of technological applications. As an alternative to liposomes, niosomes are considered more chemically and physically stable. The methods for preparing niosomes are more economic. Many reports have discussed niosomes in terms of their physicochemical properties and applications as drug delivery systems. As drug carriers, nano-sized niosomes expand the horizons of pharmacokinetics, decreasing toxicity, enhancing drug solvability and bioavailability. In this review, we review the components and fabrication methods of niosomes, as well as their functionalization, characterization, administration routes, and applications in cancer gene delivery, and natural product delivery. We also discuss the limitations and challenges in the development of niosomes, and provide the future perspective of niosomes. |
| first_indexed | 2024-03-11T15:02:05Z |
| format | Article |
| id | doaj.art-bc1a504050e6451791a929474a72c4eb |
| institution | Directory Open Access Journal |
| issn | 2590-0064 |
| language | English |
| last_indexed | 2024-03-11T15:02:05Z |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials Today Bio |
| spelling | doaj.art-bc1a504050e6451791a929474a72c4eb2023-10-30T06:08:36ZengElsevierMaterials Today Bio2590-00642023-12-0123100837Current advances in niosomes applications for drug delivery and cancer treatmentAli Moammeri0Masoumeh Mirzaei Chegeni1Hamidreza Sahrayi2Robabehbeygom Ghafelehbashi3Farkhondeh Memarzadeh4Afsoun Mansouri5Iman Akbarzadeh6Maryam Sadat Abtahi7Faranak Hejabi8Qun Ren9School of Chemical Engineering, College of Engineering, University of Tehran, Tehran, IranDepartment of Biology, Science and Research Branch, Islamic Azad University, Tehran, IranDepartment of Chemical and Petrochemical Engineering, Sharif University of Technology, Tehran, IranDepartment of Materials and Textile Engineering, College of Engineering, Razi University, Kermanshah, IranDepartment of Chemical and Petrochemical Engineering, Sharif University of Technology, Tehran, IranSchool of Pharmacy and Pharmaceutical Sciences, Tehran Medical Sciences, Islamic Azad University, Tehran, IranDepartment of Chemical and Petrochemical Engineering, Sharif University of Technology, Tehran, IranSchool of Chemical Engineering, College of Engineering, University of Tehran, Tehran, IranDepartment of Cell and Molecular Biology, Faculty of Biological Sciences, Kharazmi University, Tehran, IranLaboratory for Biointerfaces, Empa, Swiss Federal Laboratories for Materials Science and Technology, 9014, St. Gallen, Switzerland; Corresponding author.The advent of nanotechnology has led to an increased interest in nanocarriers as a drug delivery system that is efficient and safe. There have been many studies addressing nano-scale vesicular systems such as liposomes and niosome is a newer generation of vesicular nanocarriers. The niosomes provide a multilamellar carrier for lipophilic and hydrophilic bioactive substances in the self-assembled vesicle, which are composed of non-ionic surfactants in conjunction with cholesterol or other amphiphilic molecules. These non-ionic surfactant vesicles, simply known as niosomes, can be utilized in a wide variety of technological applications. As an alternative to liposomes, niosomes are considered more chemically and physically stable. The methods for preparing niosomes are more economic. Many reports have discussed niosomes in terms of their physicochemical properties and applications as drug delivery systems. As drug carriers, nano-sized niosomes expand the horizons of pharmacokinetics, decreasing toxicity, enhancing drug solvability and bioavailability. In this review, we review the components and fabrication methods of niosomes, as well as their functionalization, characterization, administration routes, and applications in cancer gene delivery, and natural product delivery. We also discuss the limitations and challenges in the development of niosomes, and provide the future perspective of niosomes.http://www.sciencedirect.com/science/article/pii/S2590006423002971Niosomes characterizationNiosome functionalizationNiosomes in gene deliveryNiosomes in cancer treatment |
| spellingShingle | Ali Moammeri Masoumeh Mirzaei Chegeni Hamidreza Sahrayi Robabehbeygom Ghafelehbashi Farkhondeh Memarzadeh Afsoun Mansouri Iman Akbarzadeh Maryam Sadat Abtahi Faranak Hejabi Qun Ren Current advances in niosomes applications for drug delivery and cancer treatment Materials Today Bio Niosomes characterization Niosome functionalization Niosomes in gene delivery Niosomes in cancer treatment |
| title | Current advances in niosomes applications for drug delivery and cancer treatment |
| title_full | Current advances in niosomes applications for drug delivery and cancer treatment |
| title_fullStr | Current advances in niosomes applications for drug delivery and cancer treatment |
| title_full_unstemmed | Current advances in niosomes applications for drug delivery and cancer treatment |
| title_short | Current advances in niosomes applications for drug delivery and cancer treatment |
| title_sort | current advances in niosomes applications for drug delivery and cancer treatment |
| topic | Niosomes characterization Niosome functionalization Niosomes in gene delivery Niosomes in cancer treatment |
| url | http://www.sciencedirect.com/science/article/pii/S2590006423002971 |
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