Landscape of histone modifications in a sponge reveals the origin of animal cis-regulatory complexity
Combinatorial patterns of histone modifications regulate developmental and cell type-specific gene expression and underpin animal complexity, but it is unclear when this regulatory system evolved. By analysing histone modifications in a morphologically-simple, early branching animal, the sponge Amph...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2017-04-01
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| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/22194 |
| _version_ | 1811253326217478144 |
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| author | Federico Gaiti Katia Jindrich Selene L Fernandez-Valverde Kathrein E Roper Bernard M Degnan Miloš Tanurdžić |
| author_facet | Federico Gaiti Katia Jindrich Selene L Fernandez-Valverde Kathrein E Roper Bernard M Degnan Miloš Tanurdžić |
| author_sort | Federico Gaiti |
| collection | DOAJ |
| description | Combinatorial patterns of histone modifications regulate developmental and cell type-specific gene expression and underpin animal complexity, but it is unclear when this regulatory system evolved. By analysing histone modifications in a morphologically-simple, early branching animal, the sponge Amphimedonqueenslandica, we show that the regulatory landscape used by complex bilaterians was already in place at the dawn of animal multicellularity. This includes distal enhancers, repressive chromatin and transcriptional units marked by H3K4me3 that vary with levels of developmental regulation. Strikingly, Amphimedon enhancers are enriched in metazoan-specific microsyntenic units, suggesting that their genomic location is extremely ancient and likely to place constraints on the evolution of surrounding genes. These results suggest that the regulatory foundation for spatiotemporal gene expression evolved prior to the divergence of sponges and eumetazoans, and was necessary for the evolution of animal multicellularity. |
| first_indexed | 2024-04-12T16:49:10Z |
| format | Article |
| id | doaj.art-bc1ab89c8cb545fe9e5e99034fafc484 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-12T16:49:10Z |
| publishDate | 2017-04-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-bc1ab89c8cb545fe9e5e99034fafc4842022-12-22T03:24:27ZengeLife Sciences Publications LtdeLife2050-084X2017-04-01610.7554/eLife.22194Landscape of histone modifications in a sponge reveals the origin of animal cis-regulatory complexityFederico Gaiti0https://orcid.org/0000-0001-5111-8816Katia Jindrich1Selene L Fernandez-Valverde2Kathrein E Roper3Bernard M Degnan4Miloš Tanurdžić5https://orcid.org/0000-0002-7564-0868School of Biological Sciences, University of Queensland, Brisbane, AustraliaSchool of Biological Sciences, University of Queensland, Brisbane, AustraliaSchool of Biological Sciences, University of Queensland, Brisbane, AustraliaSchool of Biological Sciences, University of Queensland, Brisbane, AustraliaSchool of Biological Sciences, University of Queensland, Brisbane, AustraliaSchool of Biological Sciences, University of Queensland, Brisbane, AustraliaCombinatorial patterns of histone modifications regulate developmental and cell type-specific gene expression and underpin animal complexity, but it is unclear when this regulatory system evolved. By analysing histone modifications in a morphologically-simple, early branching animal, the sponge Amphimedonqueenslandica, we show that the regulatory landscape used by complex bilaterians was already in place at the dawn of animal multicellularity. This includes distal enhancers, repressive chromatin and transcriptional units marked by H3K4me3 that vary with levels of developmental regulation. Strikingly, Amphimedon enhancers are enriched in metazoan-specific microsyntenic units, suggesting that their genomic location is extremely ancient and likely to place constraints on the evolution of surrounding genes. These results suggest that the regulatory foundation for spatiotemporal gene expression evolved prior to the divergence of sponges and eumetazoans, and was necessary for the evolution of animal multicellularity.https://elifesciences.org/articles/22194A. queenslandicaevolution of multicellularityhistone modificationscis-regulationenhancersgene expression |
| spellingShingle | Federico Gaiti Katia Jindrich Selene L Fernandez-Valverde Kathrein E Roper Bernard M Degnan Miloš Tanurdžić Landscape of histone modifications in a sponge reveals the origin of animal cis-regulatory complexity eLife A. queenslandica evolution of multicellularity histone modifications cis-regulation enhancers gene expression |
| title | Landscape of histone modifications in a sponge reveals the origin of animal cis-regulatory complexity |
| title_full | Landscape of histone modifications in a sponge reveals the origin of animal cis-regulatory complexity |
| title_fullStr | Landscape of histone modifications in a sponge reveals the origin of animal cis-regulatory complexity |
| title_full_unstemmed | Landscape of histone modifications in a sponge reveals the origin of animal cis-regulatory complexity |
| title_short | Landscape of histone modifications in a sponge reveals the origin of animal cis-regulatory complexity |
| title_sort | landscape of histone modifications in a sponge reveals the origin of animal cis regulatory complexity |
| topic | A. queenslandica evolution of multicellularity histone modifications cis-regulation enhancers gene expression |
| url | https://elifesciences.org/articles/22194 |
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