Serum Levels of Cytokines and IgE in Helminth-Infected Nigerian Pregnant Women and Children
Background: <a title="Learn more about Helminthiasis" href="https://www.sciencedirect.com/topics/medicine-and-dentistry/helminthiasis">Helminth infection</a> is an important health challenge. Because of modulation of the immune response toward T-helper 2 (Th2) cells,...
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| Format: | Article |
| Language: | English |
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Ubiquity Press
2016-03-01
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| Series: | Annals of Global Health |
| Subjects: | |
| Online Access: | https://annalsofglobalhealth.org/articles/1472 |
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| author | Ganiyu Olatunbosun Arinola Olajumoke Abimbola Morenikeji Kazeem Sanjo Akinwande Ayodele Olasoji Alade Oluwakemi Olateru-Olagbegi Ponmile Emmanuel Alabi Sheu Kadiri Rahamon |
| author_facet | Ganiyu Olatunbosun Arinola Olajumoke Abimbola Morenikeji Kazeem Sanjo Akinwande Ayodele Olasoji Alade Oluwakemi Olateru-Olagbegi Ponmile Emmanuel Alabi Sheu Kadiri Rahamon |
| author_sort | Ganiyu Olatunbosun Arinola |
| collection | DOAJ |
| description | Background: <a title="Learn more about Helminthiasis" href="https://www.sciencedirect.com/topics/medicine-and-dentistry/helminthiasis">Helminth infection</a> is an important health challenge. Because of modulation of the immune response toward T-helper 2 (Th2) cells, the immunologic interplay that manifest during the coexistence of helminth infection with other conditions is still poorly understood. Objective: This study determined the pattern of alteration in selected <a title="Learn more about Cytokines" href="https://www.sciencedirect.com/topics/medicine-and-dentistry/cytokines">cytokines</a> and <a title="Learn more about Immunoglobulin E" href="https://www.sciencedirect.com/topics/medicine-and-dentistry/immunoglobulin-e">immunoglobulin E</a>(IgE) in pregnant women, preschool aged children, and school-aged children with helminth infection compared with uninfected groups. Methods: Seventeen pregnant women, 42 preschool-aged children, and 60 school-aged children with helminth infection (HI) were recruited into this study. They were matched with 21 pregnant women, 42 preschool-aged children, and 50 school-aged children without helminth infection (HN) who served as controls. <a title="Learn more about Venous blood" href="https://www.sciencedirect.com/topics/medicine-and-dentistry/venous-blood">Venous blood</a> samples were collected from each participant and analyzed for serum levels of <a title="Learn more about Tumor Necrosis Factor" href="https://www.sciencedirect.com/topics/medicine-and-dentistry/tumor-necrosis-factor">tumor necrosis factor</a> α (TNF-α), interleukin-10 (IL-10), <a title="Learn more about Interleukin-8" href="https://www.sciencedirect.com/topics/medicine-and-dentistry/interleukin-8">interleukin-8</a> (IL-8), <a title="Learn more about Interleukin-6" href="https://www.sciencedirect.com/topics/medicine-and-dentistry/interleukin-6">interleukin-6</a> (IL-6), and IgE. Statistical analysis was done using the Student 't' test, and 'P' < .05 was considered as statistically significant. Findings: Only serum level of IgE was significantly elevated in HI pregnant women compared with HN pregnant women. In HI preschool- and school-aged children, serum levels of IL-8, IL-6, and IgE were significantly elevated compared with HN children. However, preschool- and school-aged children with HI had similar levels of serum TNF-α and IL-10 compared with their corresponding HN groups. Conclusions: It could be concluded that altered cytokines expression in children and pregnant women with helminth infection might have some implications on need for deworming programs to improve pregnancy outcomes and vaccine responses. |
| first_indexed | 2024-12-13T17:31:55Z |
| format | Article |
| id | doaj.art-bc1b37788a1f40be87b13e8e6d45ca5b |
| institution | Directory Open Access Journal |
| issn | 2214-9996 |
| language | English |
| last_indexed | 2024-12-13T17:31:55Z |
| publishDate | 2016-03-01 |
| publisher | Ubiquity Press |
| record_format | Article |
| series | Annals of Global Health |
| spelling | doaj.art-bc1b37788a1f40be87b13e8e6d45ca5b2022-12-21T23:37:01ZengUbiquity PressAnnals of Global Health2214-99962016-03-0181568969310.1016/j.aogh.2015.12.0081377Serum Levels of Cytokines and IgE in Helminth-Infected Nigerian Pregnant Women and ChildrenGaniyu Olatunbosun Arinola0Olajumoke Abimbola Morenikeji1Kazeem Sanjo Akinwande2Ayodele Olasoji Alade3Oluwakemi Olateru-Olagbegi4Ponmile Emmanuel Alabi5Sheu Kadiri Rahamon6Department of Chemical Pathology, College of Medicine, University of Ibadan, Ibadan, NigeriaDepartment of Zoology, University of Ibadan, Ibadan, NigeriaDepartment of Chemical Pathology, College of Medicine, University of Ibadan, Ibadan, NigeriaDepartment of Zoology, University of Ibadan, Ibadan, NigeriaDepartment of Chemical Pathology, College of Medicine, University of Ibadan, Ibadan, NigeriaDepartment of Zoology, University of Ibadan, Ibadan, NigeriaDepartment of Chemical Pathology, College of Medicine, University of Ibadan, Ibadan, NigeriaBackground: <a title="Learn more about Helminthiasis" href="https://www.sciencedirect.com/topics/medicine-and-dentistry/helminthiasis">Helminth infection</a> is an important health challenge. Because of modulation of the immune response toward T-helper 2 (Th2) cells, the immunologic interplay that manifest during the coexistence of helminth infection with other conditions is still poorly understood. Objective: This study determined the pattern of alteration in selected <a title="Learn more about Cytokines" href="https://www.sciencedirect.com/topics/medicine-and-dentistry/cytokines">cytokines</a> and <a title="Learn more about Immunoglobulin E" href="https://www.sciencedirect.com/topics/medicine-and-dentistry/immunoglobulin-e">immunoglobulin E</a>(IgE) in pregnant women, preschool aged children, and school-aged children with helminth infection compared with uninfected groups. Methods: Seventeen pregnant women, 42 preschool-aged children, and 60 school-aged children with helminth infection (HI) were recruited into this study. They were matched with 21 pregnant women, 42 preschool-aged children, and 50 school-aged children without helminth infection (HN) who served as controls. <a title="Learn more about Venous blood" href="https://www.sciencedirect.com/topics/medicine-and-dentistry/venous-blood">Venous blood</a> samples were collected from each participant and analyzed for serum levels of <a title="Learn more about Tumor Necrosis Factor" href="https://www.sciencedirect.com/topics/medicine-and-dentistry/tumor-necrosis-factor">tumor necrosis factor</a> α (TNF-α), interleukin-10 (IL-10), <a title="Learn more about Interleukin-8" href="https://www.sciencedirect.com/topics/medicine-and-dentistry/interleukin-8">interleukin-8</a> (IL-8), <a title="Learn more about Interleukin-6" href="https://www.sciencedirect.com/topics/medicine-and-dentistry/interleukin-6">interleukin-6</a> (IL-6), and IgE. Statistical analysis was done using the Student 't' test, and 'P' < .05 was considered as statistically significant. Findings: Only serum level of IgE was significantly elevated in HI pregnant women compared with HN pregnant women. In HI preschool- and school-aged children, serum levels of IL-8, IL-6, and IgE were significantly elevated compared with HN children. However, preschool- and school-aged children with HI had similar levels of serum TNF-α and IL-10 compared with their corresponding HN groups. Conclusions: It could be concluded that altered cytokines expression in children and pregnant women with helminth infection might have some implications on need for deworming programs to improve pregnancy outcomes and vaccine responses.https://annalsofglobalhealth.org/articles/1472childrencytokineshelminth infectionIgEpregnant women |
| spellingShingle | Ganiyu Olatunbosun Arinola Olajumoke Abimbola Morenikeji Kazeem Sanjo Akinwande Ayodele Olasoji Alade Oluwakemi Olateru-Olagbegi Ponmile Emmanuel Alabi Sheu Kadiri Rahamon Serum Levels of Cytokines and IgE in Helminth-Infected Nigerian Pregnant Women and Children Annals of Global Health children cytokines helminth infection IgE pregnant women |
| title | Serum Levels of Cytokines and IgE in Helminth-Infected Nigerian Pregnant Women and Children |
| title_full | Serum Levels of Cytokines and IgE in Helminth-Infected Nigerian Pregnant Women and Children |
| title_fullStr | Serum Levels of Cytokines and IgE in Helminth-Infected Nigerian Pregnant Women and Children |
| title_full_unstemmed | Serum Levels of Cytokines and IgE in Helminth-Infected Nigerian Pregnant Women and Children |
| title_short | Serum Levels of Cytokines and IgE in Helminth-Infected Nigerian Pregnant Women and Children |
| title_sort | serum levels of cytokines and ige in helminth infected nigerian pregnant women and children |
| topic | children cytokines helminth infection IgE pregnant women |
| url | https://annalsofglobalhealth.org/articles/1472 |
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