Prognostic factors in the acute respiratory distress syndrome
AbstractDespite improvements in critical care, acute respiratory distress syndrome (ARDS) remains a devastating clinical problem with high rates of morbidity and mortality. A better understanding of the prognostic factors associated with ARDS is crucial for facilitating risk stratification and devel...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wiley
2015-12-01
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| Series: | Clinical and Translational Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40169-015-0065-2 |
| _version_ | 1819013853305896960 |
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| author | Wei Chen Lorraine B Ware |
| author_facet | Wei Chen Lorraine B Ware |
| author_sort | Wei Chen |
| collection | DOAJ |
| description | AbstractDespite improvements in critical care, acute respiratory distress syndrome (ARDS) remains a devastating clinical problem with high rates of morbidity and mortality. A better understanding of the prognostic factors associated with ARDS is crucial for facilitating risk stratification and developing new therapeutic interventions that aim to improve clinical outcomes. In this article, we present an up‐to‐date summary of factors that predict mortality in ARDS in four categories: (1) clinical characteristics; (2) physiological parameters and oxygenation; (3) genetic polymorphisms and biomarkers; and (4) scoring systems. In addition, we discuss how a better understanding of clinical and basic pathogenic mechanisms can help to inform prognostication, decision‐making, risk stratification, treatment selection, and improve study design for clinical trials. |
| first_indexed | 2024-12-21T02:06:33Z |
| format | Article |
| id | doaj.art-bc1caba6183f4a3d856b1cce71429359 |
| institution | Directory Open Access Journal |
| issn | 2001-1326 |
| language | English |
| last_indexed | 2024-12-21T02:06:33Z |
| publishDate | 2015-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Translational Medicine |
| spelling | doaj.art-bc1caba6183f4a3d856b1cce714293592022-12-21T19:19:30ZengWileyClinical and Translational Medicine2001-13262015-12-0141n/an/a10.1186/s40169-015-0065-2Prognostic factors in the acute respiratory distress syndromeWei Chen0Lorraine B Ware1Division of Allergy, Pulmonary, and Critical Care Medicine, Department of MedicineVanderbilt University School of MedicineNashvilleUSADivision of Allergy, Pulmonary, and Critical Care Medicine, Department of MedicineVanderbilt University School of MedicineNashvilleUSAAbstractDespite improvements in critical care, acute respiratory distress syndrome (ARDS) remains a devastating clinical problem with high rates of morbidity and mortality. A better understanding of the prognostic factors associated with ARDS is crucial for facilitating risk stratification and developing new therapeutic interventions that aim to improve clinical outcomes. In this article, we present an up‐to‐date summary of factors that predict mortality in ARDS in four categories: (1) clinical characteristics; (2) physiological parameters and oxygenation; (3) genetic polymorphisms and biomarkers; and (4) scoring systems. In addition, we discuss how a better understanding of clinical and basic pathogenic mechanisms can help to inform prognostication, decision‐making, risk stratification, treatment selection, and improve study design for clinical trials.https://doi.org/10.1186/s40169-015-0065-2Acute respiratory distress syndromePrognostic factorsBiomarkersOxygenationScoring system |
| spellingShingle | Wei Chen Lorraine B Ware Prognostic factors in the acute respiratory distress syndrome Clinical and Translational Medicine Acute respiratory distress syndrome Prognostic factors Biomarkers Oxygenation Scoring system |
| title | Prognostic factors in the acute respiratory distress syndrome |
| title_full | Prognostic factors in the acute respiratory distress syndrome |
| title_fullStr | Prognostic factors in the acute respiratory distress syndrome |
| title_full_unstemmed | Prognostic factors in the acute respiratory distress syndrome |
| title_short | Prognostic factors in the acute respiratory distress syndrome |
| title_sort | prognostic factors in the acute respiratory distress syndrome |
| topic | Acute respiratory distress syndrome Prognostic factors Biomarkers Oxygenation Scoring system |
| url | https://doi.org/10.1186/s40169-015-0065-2 |
| work_keys_str_mv | AT weichen prognosticfactorsintheacuterespiratorydistresssyndrome AT lorrainebware prognosticfactorsintheacuterespiratorydistresssyndrome |