Cytoprotective Effects of β-Melanocortin in the Rat Gastrointestinal Tract
Recently discovered anti-inflammatory and immunomodulatory properties of melanocortin peptides led to the conclusion that they might serve as new anti-inflammatory therapeutics. The purpose of this work was to examine the effectiveness of β-melanocortin (β-MSH) in two experimental models: ethanol-in...
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MDPI AG
2012-10-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/17/10/11680 |
| _version_ | 1818171726029127680 |
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| author | Gorana Aralica Ana Kozmar Ivan Alerić Paško Konjevoda Mirna Bradamante Nikola Štambuk Petra Turčić |
| author_facet | Gorana Aralica Ana Kozmar Ivan Alerić Paško Konjevoda Mirna Bradamante Nikola Štambuk Petra Turčić |
| author_sort | Gorana Aralica |
| collection | DOAJ |
| description | Recently discovered anti-inflammatory and immunomodulatory properties of melanocortin peptides led to the conclusion that they might serve as new anti-inflammatory therapeutics. The purpose of this work was to examine the effectiveness of β-melanocortin (β-MSH) in two experimental models: ethanol-induced gastric lesions and TNBS (2,4,6-trinitrobenzenesulfonic acid)-induced colitis in male Wistar rats. Three progressive doses of β-MSH were used: 0.125, 0.250 and 0.500 mg/kg. Our results suggest that β-MSH acts as a protective substance in the gastric lesions model, which can be seen as a statistically significant reduction of hemorrhagic lesions at all three doses, compared to the control group. The most efficient dose was 0.250 mg/kg. Statistically significant reduction in mucosal surface affected by necrosis and the reduction of overall degree of inflammation in the colitis model indicates an anti-inflammatory effect of β-MSH at a dose of 0.250 mg/kg. The results justify further research on β-MSH peptide and its derivates in the inflammatory gastrointestinal diseases, and point out the possibility of using β-MSH in studies of digestive system pharmacology. |
| first_indexed | 2024-12-11T19:01:17Z |
| format | Article |
| id | doaj.art-bc1e12f9f1d847a0b7ea9f0f54de51fd |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-11T19:01:17Z |
| publishDate | 2012-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-bc1e12f9f1d847a0b7ea9f0f54de51fd2022-12-22T00:54:01ZengMDPI AGMolecules1420-30492012-10-011710116801169210.3390/molecules171011680Cytoprotective Effects of β-Melanocortin in the Rat Gastrointestinal TractGorana AralicaAna KozmarIvan AlerićPaško KonjevodaMirna BradamanteNikola ŠtambukPetra TurčićRecently discovered anti-inflammatory and immunomodulatory properties of melanocortin peptides led to the conclusion that they might serve as new anti-inflammatory therapeutics. The purpose of this work was to examine the effectiveness of β-melanocortin (β-MSH) in two experimental models: ethanol-induced gastric lesions and TNBS (2,4,6-trinitrobenzenesulfonic acid)-induced colitis in male Wistar rats. Three progressive doses of β-MSH were used: 0.125, 0.250 and 0.500 mg/kg. Our results suggest that β-MSH acts as a protective substance in the gastric lesions model, which can be seen as a statistically significant reduction of hemorrhagic lesions at all three doses, compared to the control group. The most efficient dose was 0.250 mg/kg. Statistically significant reduction in mucosal surface affected by necrosis and the reduction of overall degree of inflammation in the colitis model indicates an anti-inflammatory effect of β-MSH at a dose of 0.250 mg/kg. The results justify further research on β-MSH peptide and its derivates in the inflammatory gastrointestinal diseases, and point out the possibility of using β-MSH in studies of digestive system pharmacology.http://www.mdpi.com/1420-3049/17/10/11680β-melanocortincytoprotectiongastritiscolitisTNBShepatoprotection |
| spellingShingle | Gorana Aralica Ana Kozmar Ivan Alerić Paško Konjevoda Mirna Bradamante Nikola Štambuk Petra Turčić Cytoprotective Effects of β-Melanocortin in the Rat Gastrointestinal Tract Molecules β-melanocortin cytoprotection gastritis colitis TNBS hepatoprotection |
| title | Cytoprotective Effects of β-Melanocortin in the Rat Gastrointestinal Tract |
| title_full | Cytoprotective Effects of β-Melanocortin in the Rat Gastrointestinal Tract |
| title_fullStr | Cytoprotective Effects of β-Melanocortin in the Rat Gastrointestinal Tract |
| title_full_unstemmed | Cytoprotective Effects of β-Melanocortin in the Rat Gastrointestinal Tract |
| title_short | Cytoprotective Effects of β-Melanocortin in the Rat Gastrointestinal Tract |
| title_sort | cytoprotective effects of β melanocortin in the rat gastrointestinal tract |
| topic | β-melanocortin cytoprotection gastritis colitis TNBS hepatoprotection |
| url | http://www.mdpi.com/1420-3049/17/10/11680 |
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