Association of concomitant continuous pain in trigeminal neuralgia with a narrow foramen ovale
BackgroundThe pathogenesis of concomitant continuous pain remains unclear and is worthy of further study. In this clinical study, we aimed to explore the potential role of a narrow foramen ovale in the development of concomitant continuous pain.MethodsA total of 108 patients with classical trigemina...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-10-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2023.1277654/full |
| _version_ | 1797644364605816832 |
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| author | Shuo Li Chenlong Liao Xiaosheng Yang Wenchuan Zhang |
| author_facet | Shuo Li Chenlong Liao Xiaosheng Yang Wenchuan Zhang |
| author_sort | Shuo Li |
| collection | DOAJ |
| description | BackgroundThe pathogenesis of concomitant continuous pain remains unclear and is worthy of further study. In this clinical study, we aimed to explore the potential role of a narrow foramen ovale in the development of concomitant continuous pain.MethodsA total of 108 patients with classical trigeminal neuralgia affecting the third branch of the trigeminal nerve and 46 healthy individuals were enrolled in this study. Three-dimensional reconstructed computerized tomography images of all participants were collected, and the morphometric features of the foramen ovale were examined by two investigators who were blinded to the clinical data of the patients.ResultsIn this cohort, patients with concomitant continuous pain suffered from more sensory abnormalities (18.4% vs. 2.9%, p = 0.015) and responded more poorly to medication (74.3% vs. 91.9%, p = 0.018) than patients without concomitant continuous pain. While no significant differences regarding the mean length (5.02 mm vs. 5.36 mm, p > 0.05) and area (22.14 mm2 vs. 23.80 mm2, p > 0.05) were observed between patients with and without concomitant continuous pain, the mean width of the foramen ovale on the affected side in patients with concomitant continuous pain was significantly narrower than that in patients without concomitant continuous pain (2.01 mm vs. 2.48 mm, p = 0.003).ConclusionThis neuroimaging and clinical study demonstrated that the development of concomitant continuous pain was caused by the compression of the trigeminal nerve owing to a narrow foramen ovale rather than responsible vessels in classical trigeminal neuralgia. |
| first_indexed | 2024-03-11T14:29:29Z |
| format | Article |
| id | doaj.art-bc1e4ffa390b4c37be11ca026dbaaac9 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-03-11T14:29:29Z |
| publishDate | 2023-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-bc1e4ffa390b4c37be11ca026dbaaac92023-10-31T10:21:55ZengFrontiers Media S.A.Frontiers in Neurology1664-22952023-10-011410.3389/fneur.2023.12776541277654Association of concomitant continuous pain in trigeminal neuralgia with a narrow foramen ovaleShuo LiChenlong LiaoXiaosheng YangWenchuan ZhangBackgroundThe pathogenesis of concomitant continuous pain remains unclear and is worthy of further study. In this clinical study, we aimed to explore the potential role of a narrow foramen ovale in the development of concomitant continuous pain.MethodsA total of 108 patients with classical trigeminal neuralgia affecting the third branch of the trigeminal nerve and 46 healthy individuals were enrolled in this study. Three-dimensional reconstructed computerized tomography images of all participants were collected, and the morphometric features of the foramen ovale were examined by two investigators who were blinded to the clinical data of the patients.ResultsIn this cohort, patients with concomitant continuous pain suffered from more sensory abnormalities (18.4% vs. 2.9%, p = 0.015) and responded more poorly to medication (74.3% vs. 91.9%, p = 0.018) than patients without concomitant continuous pain. While no significant differences regarding the mean length (5.02 mm vs. 5.36 mm, p > 0.05) and area (22.14 mm2 vs. 23.80 mm2, p > 0.05) were observed between patients with and without concomitant continuous pain, the mean width of the foramen ovale on the affected side in patients with concomitant continuous pain was significantly narrower than that in patients without concomitant continuous pain (2.01 mm vs. 2.48 mm, p = 0.003).ConclusionThis neuroimaging and clinical study demonstrated that the development of concomitant continuous pain was caused by the compression of the trigeminal nerve owing to a narrow foramen ovale rather than responsible vessels in classical trigeminal neuralgia.https://www.frontiersin.org/articles/10.3389/fneur.2023.1277654/fulltrigeminal neuralgiaforamen ovaleconcomitant continuous painetiologyatypical pain |
| spellingShingle | Shuo Li Chenlong Liao Xiaosheng Yang Wenchuan Zhang Association of concomitant continuous pain in trigeminal neuralgia with a narrow foramen ovale Frontiers in Neurology trigeminal neuralgia foramen ovale concomitant continuous pain etiology atypical pain |
| title | Association of concomitant continuous pain in trigeminal neuralgia with a narrow foramen ovale |
| title_full | Association of concomitant continuous pain in trigeminal neuralgia with a narrow foramen ovale |
| title_fullStr | Association of concomitant continuous pain in trigeminal neuralgia with a narrow foramen ovale |
| title_full_unstemmed | Association of concomitant continuous pain in trigeminal neuralgia with a narrow foramen ovale |
| title_short | Association of concomitant continuous pain in trigeminal neuralgia with a narrow foramen ovale |
| title_sort | association of concomitant continuous pain in trigeminal neuralgia with a narrow foramen ovale |
| topic | trigeminal neuralgia foramen ovale concomitant continuous pain etiology atypical pain |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2023.1277654/full |
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