Factors in the etiopathogenesis of post-adolescent female acne

Background and Design: Post-adolescent acne has been defined as acne that persists or whose onset starts beyond the age of 25 years. The presence of hyperandrogenemia, polycystic ovary syndrome (PCOS), dyslipidemia, and insulin sensitivity play a role in etiopathogenesis of post-adolescent acne in w...

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Main Authors: Ezgi Özkur, Damla Demir, İlknur Kıvanç Altunay, Mustafa Demir, Oktay Tosun
Format: Article
Language:English
Published: Galenos Publishing House 2021-09-01
Series:Turkderm Turkish Archives of Dermatology and Venereology
Subjects:
Online Access:https://journal.turkderm.org.tr/jvi.aspx?pdir=turkderm&plng=eng&un=TURKDERM-04382&look4=
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author Ezgi Özkur
Damla Demir
İlknur Kıvanç Altunay
Mustafa Demir
Oktay Tosun
author_facet Ezgi Özkur
Damla Demir
İlknur Kıvanç Altunay
Mustafa Demir
Oktay Tosun
author_sort Ezgi Özkur
collection DOAJ
description Background and Design: Post-adolescent acne has been defined as acne that persists or whose onset starts beyond the age of 25 years. The presence of hyperandrogenemia, polycystic ovary syndrome (PCOS), dyslipidemia, and insulin sensitivity play a role in etiopathogenesis of post-adolescent acne in women as shown in previous studies. This study was conducted to investigate these relationships. Materials and Methods: We included 45 female patients with post-adolescent acne and 30 age, sex, and body mass index-matched healthy controls. Demographic characteristics, clinical signs of hyperandrogenemia, pelvic ultrasound scan, and hormonal assessment including the [total testosterone (TT), sex hormone binding globulin (SHBG), dehydroepiandrosterone sulfate (DHEAS), follicle stimulating hormone (FSH), luteinizing hormone (LH), prolactin (PRL), estradiol (E2)] and fasting plasma glucose, and insulin and lipid levels were recorded. Results: Woman with post-adolescent acne had the marked presence of menstrual abnormalities (37.7%), hirsutism (13.3%), androgenetic alopecia (11.1%), metabolic syndrome (MS) (32.4%), and PCOS (22.2%). Pelvic ultrasound scans showed that 17.8% of the patients had polycystic ovaries. In addition, the percentage of current smokers was significantly higher in the patient group than the controls (p=0.001). TT and LH were significantly higher in post-adolescent acne patients than the controls (p=0.048, and p=0.012, respectively). No significant differences were observed between patients and controls in terms of SHBG, DHEAS, FSH, PRL, E2, and total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and triglyceride levels. No correlations were observed between these parameters and the severity of acne. Conclusion: Although laboratory hormonal assessment showed no significant difference, post-adolescent acne patients had marked menstrual irregularities, polycystic ovaries, androgenetic alopecia, hirsutism, and MS. However, insulin resistance and dyslipidemia may not play a major role in the pathogenesis of post-adolescent female acne.
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spelling doaj.art-bc1e5de9df624e21a08e1eb369c120222023-02-15T16:08:50ZengGalenos Publishing HouseTurkderm Turkish Archives of Dermatology and Venereology2651-51642021-09-0155311912410.4274/turkderm.galenos.2021.04382Factors in the etiopathogenesis of post-adolescent female acneEzgi Özkur0https://orcid.org/0000-0002-9136-7021Damla Demir1https://orcid.org/0000-0001-9637-0206İlknur Kıvanç Altunay2https://orcid.org/0000-0002-1354-7123Mustafa Demir3https://orcid.org/0000-0001-6823-0935Oktay Tosun4https://orcid.org/0000-0003-0874-1324University of Health Sciences Turkey, Şişli Hamidiye Etfal Training and Research Hospital, Clinic of Dermatology, İstanbul, TurkeyUniversity of Health Sciences Turkey, Ümraniye Training and Research Hospital, Clinic of Dermatology, İstanbul, TurkeyUniversity of Health Sciences Turkey, Şişli Hamidiye Etfal Training and Research Hospital, Clinic of Dermatology, İstanbul, TurkeyUniversity of Health Sciences Turkey, Ümraniye Training and Research Hospital, Clinic of Radiology, İstanbul, TurkeyUniversity of Health Sciences Turkey, Şişli Hamidiye Etfal Training and Research Hospital, Clinic of Gynecology and Obstetrics, İstanbul, TurkeyBackground and Design: Post-adolescent acne has been defined as acne that persists or whose onset starts beyond the age of 25 years. The presence of hyperandrogenemia, polycystic ovary syndrome (PCOS), dyslipidemia, and insulin sensitivity play a role in etiopathogenesis of post-adolescent acne in women as shown in previous studies. This study was conducted to investigate these relationships. Materials and Methods: We included 45 female patients with post-adolescent acne and 30 age, sex, and body mass index-matched healthy controls. Demographic characteristics, clinical signs of hyperandrogenemia, pelvic ultrasound scan, and hormonal assessment including the [total testosterone (TT), sex hormone binding globulin (SHBG), dehydroepiandrosterone sulfate (DHEAS), follicle stimulating hormone (FSH), luteinizing hormone (LH), prolactin (PRL), estradiol (E2)] and fasting plasma glucose, and insulin and lipid levels were recorded. Results: Woman with post-adolescent acne had the marked presence of menstrual abnormalities (37.7%), hirsutism (13.3%), androgenetic alopecia (11.1%), metabolic syndrome (MS) (32.4%), and PCOS (22.2%). Pelvic ultrasound scans showed that 17.8% of the patients had polycystic ovaries. In addition, the percentage of current smokers was significantly higher in the patient group than the controls (p=0.001). TT and LH were significantly higher in post-adolescent acne patients than the controls (p=0.048, and p=0.012, respectively). No significant differences were observed between patients and controls in terms of SHBG, DHEAS, FSH, PRL, E2, and total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and triglyceride levels. No correlations were observed between these parameters and the severity of acne. Conclusion: Although laboratory hormonal assessment showed no significant difference, post-adolescent acne patients had marked menstrual irregularities, polycystic ovaries, androgenetic alopecia, hirsutism, and MS. However, insulin resistance and dyslipidemia may not play a major role in the pathogenesis of post-adolescent female acne.https://journal.turkderm.org.tr/jvi.aspx?pdir=turkderm&plng=eng&un=TURKDERM-04382&look4=acnehyperandrogenemiapolycystic ovary syndromedyslipidemiainsulin sensitivity
spellingShingle Ezgi Özkur
Damla Demir
İlknur Kıvanç Altunay
Mustafa Demir
Oktay Tosun
Factors in the etiopathogenesis of post-adolescent female acne
Turkderm Turkish Archives of Dermatology and Venereology
acne
hyperandrogenemia
polycystic ovary syndrome
dyslipidemia
insulin sensitivity
title Factors in the etiopathogenesis of post-adolescent female acne
title_full Factors in the etiopathogenesis of post-adolescent female acne
title_fullStr Factors in the etiopathogenesis of post-adolescent female acne
title_full_unstemmed Factors in the etiopathogenesis of post-adolescent female acne
title_short Factors in the etiopathogenesis of post-adolescent female acne
title_sort factors in the etiopathogenesis of post adolescent female acne
topic acne
hyperandrogenemia
polycystic ovary syndrome
dyslipidemia
insulin sensitivity
url https://journal.turkderm.org.tr/jvi.aspx?pdir=turkderm&plng=eng&un=TURKDERM-04382&look4=
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AT mustafademir factorsintheetiopathogenesisofpostadolescentfemaleacne
AT oktaytosun factorsintheetiopathogenesisofpostadolescentfemaleacne