Revolutionize livestock breeding in the future: an animal embryo-stem cell breeding system in a dish
Abstract Meat and milk production needs to increase ~ 70–80% relative to its current levels for satisfying the human needs in 2050. However, it is impossible to achieve such genetic gain by conventional animal breeding systems. Based on recent advances with regard to in vitro induction of germ cell...
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| Format: | Article |
| Language: | English |
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BMC
2018-12-01
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| Series: | Journal of Animal Science and Biotechnology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s40104-018-0304-7 |
| _version_ | 1818521790472781824 |
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| author | Zhuocheng Hou Lei An Jianyong Han Ye Yuan Dongbao Chen Jianhui Tian |
| author_facet | Zhuocheng Hou Lei An Jianyong Han Ye Yuan Dongbao Chen Jianhui Tian |
| author_sort | Zhuocheng Hou |
| collection | DOAJ |
| description | Abstract Meat and milk production needs to increase ~ 70–80% relative to its current levels for satisfying the human needs in 2050. However, it is impossible to achieve such genetic gain by conventional animal breeding systems. Based on recent advances with regard to in vitro induction of germ cell from pluripotent stem cells, herein we propose a novel embryo-stem cell breeding system. Distinct from the conventional breeding system in farm animals that involves selecting and mating individuals, the novel breeding system completes breeding cycles from parental to offspring embryos directly by selecting and mating embryos in a dish. In comparison to the conventional dairy breeding scheme, this system can rapidly achieve 30–40 times more genetic gain by significantly shortening generation interval and enhancing selection intensity. However, several major obstacles must be overcome before we can fully use this system in livestock breeding, which include derivation and mantaince of pluripotent stem cells in domestic animals, as well as in vitro induction of primordial germ cells, and subsequent haploid gametes. Thus, we also discuss the potential efforts needed in solving the obstacles for application this novel system, and elaborate on their groundbreaking potential in livestock breeding. This novel system would provide a revolutionary animal breeding system by offering an unprecedented opportunity for meeting the fast-growing meat and milk demand of humans. |
| first_indexed | 2024-12-11T01:56:02Z |
| format | Article |
| id | doaj.art-bc1f9b8e660d4330b7c78833a757a1a9 |
| institution | Directory Open Access Journal |
| issn | 2049-1891 |
| language | English |
| last_indexed | 2024-12-11T01:56:02Z |
| publishDate | 2018-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Animal Science and Biotechnology |
| spelling | doaj.art-bc1f9b8e660d4330b7c78833a757a1a92022-12-22T01:24:38ZengBMCJournal of Animal Science and Biotechnology2049-18912018-12-019111110.1186/s40104-018-0304-7Revolutionize livestock breeding in the future: an animal embryo-stem cell breeding system in a dishZhuocheng Hou0Lei An1Jianyong Han2Ye Yuan3Dongbao Chen4Jianhui Tian5Key Laboratory of Animal Genetics, Breeding and Reproduction of the Ministry of Agriculture, National Engineering Laboratory for Animal Breeding, College of Animal Science and Technology, China Agricultural UniversityKey Laboratory of Animal Genetics, Breeding and Reproduction of the Ministry of Agriculture, National Engineering Laboratory for Animal Breeding, College of Animal Science and Technology, China Agricultural UniversityState Key Laboratories for Agrobiotechnology, College of Biological Sciences, China Agricultural UniversityColorado Center for Reproductive MedicineDepartment of Obstetrics and Gynecology, University of California IrvineKey Laboratory of Animal Genetics, Breeding and Reproduction of the Ministry of Agriculture, National Engineering Laboratory for Animal Breeding, College of Animal Science and Technology, China Agricultural UniversityAbstract Meat and milk production needs to increase ~ 70–80% relative to its current levels for satisfying the human needs in 2050. However, it is impossible to achieve such genetic gain by conventional animal breeding systems. Based on recent advances with regard to in vitro induction of germ cell from pluripotent stem cells, herein we propose a novel embryo-stem cell breeding system. Distinct from the conventional breeding system in farm animals that involves selecting and mating individuals, the novel breeding system completes breeding cycles from parental to offspring embryos directly by selecting and mating embryos in a dish. In comparison to the conventional dairy breeding scheme, this system can rapidly achieve 30–40 times more genetic gain by significantly shortening generation interval and enhancing selection intensity. However, several major obstacles must be overcome before we can fully use this system in livestock breeding, which include derivation and mantaince of pluripotent stem cells in domestic animals, as well as in vitro induction of primordial germ cells, and subsequent haploid gametes. Thus, we also discuss the potential efforts needed in solving the obstacles for application this novel system, and elaborate on their groundbreaking potential in livestock breeding. This novel system would provide a revolutionary animal breeding system by offering an unprecedented opportunity for meeting the fast-growing meat and milk demand of humans.http://link.springer.com/article/10.1186/s40104-018-0304-7Animal breedingEmbryosGenomic selectionIn vitro germ cell inductionPluripotent stem cells |
| spellingShingle | Zhuocheng Hou Lei An Jianyong Han Ye Yuan Dongbao Chen Jianhui Tian Revolutionize livestock breeding in the future: an animal embryo-stem cell breeding system in a dish Journal of Animal Science and Biotechnology Animal breeding Embryos Genomic selection In vitro germ cell induction Pluripotent stem cells |
| title | Revolutionize livestock breeding in the future: an animal embryo-stem cell breeding system in a dish |
| title_full | Revolutionize livestock breeding in the future: an animal embryo-stem cell breeding system in a dish |
| title_fullStr | Revolutionize livestock breeding in the future: an animal embryo-stem cell breeding system in a dish |
| title_full_unstemmed | Revolutionize livestock breeding in the future: an animal embryo-stem cell breeding system in a dish |
| title_short | Revolutionize livestock breeding in the future: an animal embryo-stem cell breeding system in a dish |
| title_sort | revolutionize livestock breeding in the future an animal embryo stem cell breeding system in a dish |
| topic | Animal breeding Embryos Genomic selection In vitro germ cell induction Pluripotent stem cells |
| url | http://link.springer.com/article/10.1186/s40104-018-0304-7 |
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