A rare case of alpha-methyldopa-induced hepatitis in pregnancy
Introduction. There are three groups of disorders during pregnancy: disorders specific for pregnancy that resolve spontaneously or soon after delivery, acute hepatic disorders coinciding with pregnancy, and chronic disorders. Drug-induced liver disease prevails among women and it is estimated to be...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Serbian Medical Society
2024-01-01
|
| Series: | Srpski Arhiv za Celokupno Lekarstvo |
| Subjects: | |
| Online Access: | https://doiserbia.nb.rs/img/doi/0370-8179/2024/0370-81792400004L.pdf |
| _version_ | 1827288418059550720 |
|---|---|
| author | Likić-Lađević Ivana Petronijević Miloš Vrzić-Petronijević Svetlana Beleslin Aleksandra Dugalić Stefan |
| author_facet | Likić-Lađević Ivana Petronijević Miloš Vrzić-Petronijević Svetlana Beleslin Aleksandra Dugalić Stefan |
| author_sort | Likić-Lađević Ivana |
| collection | DOAJ |
| description | Introduction. There are three groups of disorders during pregnancy: disorders specific for pregnancy that resolve spontaneously or soon after delivery, acute hepatic disorders coinciding with pregnancy, and chronic disorders. Drug-induced liver disease prevails among women and it is estimated to be a leading cause of acute liver injury. Drug-induced hepatitis is rare in pregnancy with only a few cases reported in literature. Alpha-methyldopa is one of the commonly used drugs in pregnancy that could cause hepatotoxicity with different clinical presentations and possible adverse effects on normal course of pregnancy. Case outline. We reported a rare case of hepatotoxicity caused by alpha-methyldopa in 26 gestational weeks pregnancy in a 35-year-old patient admitted because of jaundice and elevated liver function tests. She had been using antihypertensive drug, alpha-methyldopa, from 12th gestational week, and no other medication or supplementation was recorded. Ultrasound of the abdomen excluded obstruction or any other abnormalities. Autoimmune panel was done. Biochemical analyses were indicative of toxic acute liver injury caused by alpha-methyldopa according to values of transaminase. After 13 days, patient was discharged recovered from the hospital. Conclusion. Diagnosis of alpha-methyldopa hepatotoxicity is challenging since the low incidence, unpredictability, diverse symptomatology and absence of specific biomarkers. That is why timely diagnosis is crucial for the well-being of both future mother and child. |
| first_indexed | 2024-04-24T11:31:17Z |
| format | Article |
| id | doaj.art-bc21bc0e19494059b433b91e94ba605f |
| institution | Directory Open Access Journal |
| issn | 0370-8179 2406-0895 |
| language | English |
| last_indexed | 2024-04-24T11:31:17Z |
| publishDate | 2024-01-01 |
| publisher | Serbian Medical Society |
| record_format | Article |
| series | Srpski Arhiv za Celokupno Lekarstvo |
| spelling | doaj.art-bc21bc0e19494059b433b91e94ba605f2024-04-10T10:20:17ZengSerbian Medical SocietySrpski Arhiv za Celokupno Lekarstvo0370-81792406-08952024-01-011521-2858710.2298/SARH231107004L0370-81792400004LA rare case of alpha-methyldopa-induced hepatitis in pregnancyLikić-Lađević Ivana0https://orcid.org/0000-0001-9743-2528Petronijević Miloš1https://orcid.org/0000-0003-4957-4729Vrzić-Petronijević Svetlana2https://orcid.org/0000-0001-5874-9725Beleslin Aleksandra3https://orcid.org/0000-0002-2407-8975Dugalić Stefan4https://orcid.org/0000-0001-5292-0595University Clinical Centre of Serbia, Clinic for Gynecology and Obstetrics, Belgrade, Serbia + University of Belgrade, Faculty of Medicine, Belgrade, SerbiaUniversity Clinical Centre of Serbia, Clinic for Gynecology and Obstetrics, Belgrade, Serbia + University of Belgrade, Faculty of Medicine, Belgrade, SerbiaUniversity Clinical Centre of Serbia, Clinic for Gynecology and Obstetrics, Belgrade, Serbia + University of Belgrade, Faculty of Medicine, Belgrade, SerbiaUniversity Clinical Centre of Serbia, Clinic for Gynecology and Obstetrics, Belgrade, SerbiaUniversity Clinical Centre of Serbia, Clinic for Gynecology and Obstetrics, Belgrade, Serbia + University of Belgrade, Faculty of Medicine, Belgrade, SerbiaIntroduction. There are three groups of disorders during pregnancy: disorders specific for pregnancy that resolve spontaneously or soon after delivery, acute hepatic disorders coinciding with pregnancy, and chronic disorders. Drug-induced liver disease prevails among women and it is estimated to be a leading cause of acute liver injury. Drug-induced hepatitis is rare in pregnancy with only a few cases reported in literature. Alpha-methyldopa is one of the commonly used drugs in pregnancy that could cause hepatotoxicity with different clinical presentations and possible adverse effects on normal course of pregnancy. Case outline. We reported a rare case of hepatotoxicity caused by alpha-methyldopa in 26 gestational weeks pregnancy in a 35-year-old patient admitted because of jaundice and elevated liver function tests. She had been using antihypertensive drug, alpha-methyldopa, from 12th gestational week, and no other medication or supplementation was recorded. Ultrasound of the abdomen excluded obstruction or any other abnormalities. Autoimmune panel was done. Biochemical analyses were indicative of toxic acute liver injury caused by alpha-methyldopa according to values of transaminase. After 13 days, patient was discharged recovered from the hospital. Conclusion. Diagnosis of alpha-methyldopa hepatotoxicity is challenging since the low incidence, unpredictability, diverse symptomatology and absence of specific biomarkers. That is why timely diagnosis is crucial for the well-being of both future mother and child.https://doiserbia.nb.rs/img/doi/0370-8179/2024/0370-81792400004L.pdfdrug-induced hepatitisalpha-methyldopahypertension in pregnancyhepatotoxicity |
| spellingShingle | Likić-Lađević Ivana Petronijević Miloš Vrzić-Petronijević Svetlana Beleslin Aleksandra Dugalić Stefan A rare case of alpha-methyldopa-induced hepatitis in pregnancy Srpski Arhiv za Celokupno Lekarstvo drug-induced hepatitis alpha-methyldopa hypertension in pregnancy hepatotoxicity |
| title | A rare case of alpha-methyldopa-induced hepatitis in pregnancy |
| title_full | A rare case of alpha-methyldopa-induced hepatitis in pregnancy |
| title_fullStr | A rare case of alpha-methyldopa-induced hepatitis in pregnancy |
| title_full_unstemmed | A rare case of alpha-methyldopa-induced hepatitis in pregnancy |
| title_short | A rare case of alpha-methyldopa-induced hepatitis in pregnancy |
| title_sort | rare case of alpha methyldopa induced hepatitis in pregnancy |
| topic | drug-induced hepatitis alpha-methyldopa hypertension in pregnancy hepatotoxicity |
| url | https://doiserbia.nb.rs/img/doi/0370-8179/2024/0370-81792400004L.pdf |
| work_keys_str_mv | AT likiclađevicivana ararecaseofalphamethyldopainducedhepatitisinpregnancy AT petronijevicmilos ararecaseofalphamethyldopainducedhepatitisinpregnancy AT vrzicpetronijevicsvetlana ararecaseofalphamethyldopainducedhepatitisinpregnancy AT beleslinaleksandra ararecaseofalphamethyldopainducedhepatitisinpregnancy AT dugalicstefan ararecaseofalphamethyldopainducedhepatitisinpregnancy AT likiclađevicivana rarecaseofalphamethyldopainducedhepatitisinpregnancy AT petronijevicmilos rarecaseofalphamethyldopainducedhepatitisinpregnancy AT vrzicpetronijevicsvetlana rarecaseofalphamethyldopainducedhepatitisinpregnancy AT beleslinaleksandra rarecaseofalphamethyldopainducedhepatitisinpregnancy AT dugalicstefan rarecaseofalphamethyldopainducedhepatitisinpregnancy |