Knockdown of PGM1 enhances anticancer effects of orlistat in gastric cancer under glucose deprivation

Knockdown of PGM1 enhances anticancer effects of orlistat in gastric cancer under glucose deprivation

Abstract Background Phosphoglucomutase 1 (PGM1) acts as an important regulator in glucose metabolism. However, the role of PGM1 in gastric cancer (GC) remains unclear. This study aims to investigate the role of PGM1 and develop novel regimens based on metabolic reprogramming in GC. Methods Correlati...

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Bibliographic Details
Main Authors: Bo Cao, Huan Deng, Hao Cui, Ruiyang Zhao, Hanghang Li, Bo Wei, Lin Chen
Format: Article
Language:English
Published: BMC 2021-09-01
Series:Cancer Cell International
Subjects:
Gastric cancer
Phosphoglucomutase 1
Orlistat
Glucose deprivation
Cancer metabolism
Apoptosis
Online Access:https://doi.org/10.1186/s12935-021-02193-3

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