Human Cytomegalovirus UL23 Antagonizes the Antiviral Effect of Interferon-γ by Restraining the Expression of Specific IFN-Stimulated Genes

Human Cytomegalovirus UL23 Antagonizes the Antiviral Effect of Interferon-γ by Restraining the Expression of Specific IFN-Stimulated Genes

Interferon-γ (IFN-γ) is a critical component of innate immune responses in humans to combat infection by many viruses, including human cytomegalovirus (HCMV). IFN-γ exerts its biological effects by inducing hundreds of IFN-stimulated genes (ISGs). In this study, RNA-seq analyses revealed that HCMV t...

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Bibliographic Details
Main Authors: Hankun Wang, Weijian Peng, Jialin Wang, Chunling Zhang, Wangchun Zhao, Yanhong Ran, Xiaoping Yang, Jun Chen, Hongjian Li
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:Viruses
Subjects:
interferon-γ (IFN-γ)
human cytomegalovirus
HCMV
UL23
IFN-stimulated genes
ISG
Online Access:https://www.mdpi.com/1999-4915/15/4/1014

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