OMICS Applications for Medicinal Plants in Gastrointestinal Cancers: Current Advancements and Future Perspectives
Gastrointestinal cancers refer to a group of deadly malignancies of the gastrointestinal tract and organs of the digestive system. Over the past decades, considerable amounts of medicinal plants have exhibited potent anticancer effects on different types of gastrointestinal cancers. OMICS, systems b...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-02-01
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| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2022.842203/full |
| _version_ | 1818510268652584960 |
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| author | Rongchen Dai Rongchen Dai Mengfan Liu Mengfan Liu Xincheng Xiang Xincheng Xiang Yang Li Yang Li Zhichao Xi Zhichao Xi Hongxi Xu |
| author_facet | Rongchen Dai Rongchen Dai Mengfan Liu Mengfan Liu Xincheng Xiang Xincheng Xiang Yang Li Yang Li Zhichao Xi Zhichao Xi Hongxi Xu |
| author_sort | Rongchen Dai |
| collection | DOAJ |
| description | Gastrointestinal cancers refer to a group of deadly malignancies of the gastrointestinal tract and organs of the digestive system. Over the past decades, considerable amounts of medicinal plants have exhibited potent anticancer effects on different types of gastrointestinal cancers. OMICS, systems biology approaches covering genomics, transcriptomics, proteomics and metabolomics, are broadly applied to comprehensively reflect the molecular profiles in mechanistic studies of medicinal plants. Single- and multi-OMICS approaches facilitate the unravelling of signalling interaction networks and key molecular targets of medicinal plants with anti-gastrointestinal cancer potential. Hence, this review summarizes the applications of various OMICS and advanced bioinformatics approaches in examining therapeutic targets, signalling pathways, and the tumour microenvironment in response to anticancer medicinal plants. Advances and prospects in this field are also discussed. |
| first_indexed | 2024-12-10T22:56:56Z |
| format | Article |
| id | doaj.art-bc23291970f0485dbafcc10e31e2c4cc |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-12-10T22:56:56Z |
| publishDate | 2022-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-bc23291970f0485dbafcc10e31e2c4cc2022-12-22T01:30:15ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122022-02-011310.3389/fphar.2022.842203842203OMICS Applications for Medicinal Plants in Gastrointestinal Cancers: Current Advancements and Future PerspectivesRongchen Dai0Rongchen Dai1Mengfan Liu2Mengfan Liu3Xincheng Xiang4Xincheng Xiang5Yang Li6Yang Li7Zhichao Xi8Zhichao Xi9Hongxi Xu10School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaEngineering Research Center of Shanghai Colleges for TCM New Drug Discovery, Shanghai, ChinaSchool of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaEngineering Research Center of Shanghai Colleges for TCM New Drug Discovery, Shanghai, ChinaSchool of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaEngineering Research Center of Shanghai Colleges for TCM New Drug Discovery, Shanghai, ChinaSchool of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaEngineering Research Center of Shanghai Colleges for TCM New Drug Discovery, Shanghai, ChinaSchool of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaEngineering Research Center of Shanghai Colleges for TCM New Drug Discovery, Shanghai, ChinaShuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaGastrointestinal cancers refer to a group of deadly malignancies of the gastrointestinal tract and organs of the digestive system. Over the past decades, considerable amounts of medicinal plants have exhibited potent anticancer effects on different types of gastrointestinal cancers. OMICS, systems biology approaches covering genomics, transcriptomics, proteomics and metabolomics, are broadly applied to comprehensively reflect the molecular profiles in mechanistic studies of medicinal plants. Single- and multi-OMICS approaches facilitate the unravelling of signalling interaction networks and key molecular targets of medicinal plants with anti-gastrointestinal cancer potential. Hence, this review summarizes the applications of various OMICS and advanced bioinformatics approaches in examining therapeutic targets, signalling pathways, and the tumour microenvironment in response to anticancer medicinal plants. Advances and prospects in this field are also discussed.https://www.frontiersin.org/articles/10.3389/fphar.2022.842203/fullgastrointestinal cancersomicsmedicinal plantsmulti-omicsprecision medicinetumour heterogeneity |
| spellingShingle | Rongchen Dai Rongchen Dai Mengfan Liu Mengfan Liu Xincheng Xiang Xincheng Xiang Yang Li Yang Li Zhichao Xi Zhichao Xi Hongxi Xu OMICS Applications for Medicinal Plants in Gastrointestinal Cancers: Current Advancements and Future Perspectives Frontiers in Pharmacology gastrointestinal cancers omics medicinal plants multi-omics precision medicine tumour heterogeneity |
| title | OMICS Applications for Medicinal Plants in Gastrointestinal Cancers: Current Advancements and Future Perspectives |
| title_full | OMICS Applications for Medicinal Plants in Gastrointestinal Cancers: Current Advancements and Future Perspectives |
| title_fullStr | OMICS Applications for Medicinal Plants in Gastrointestinal Cancers: Current Advancements and Future Perspectives |
| title_full_unstemmed | OMICS Applications for Medicinal Plants in Gastrointestinal Cancers: Current Advancements and Future Perspectives |
| title_short | OMICS Applications for Medicinal Plants in Gastrointestinal Cancers: Current Advancements and Future Perspectives |
| title_sort | omics applications for medicinal plants in gastrointestinal cancers current advancements and future perspectives |
| topic | gastrointestinal cancers omics medicinal plants multi-omics precision medicine tumour heterogeneity |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2022.842203/full |
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