Food as a trigger for abdominal angioedema attacks in patients with hereditary angioedema
Abstract Background Hereditary angioedema with C1 inhibitor deficiency (C1-INH-HAE) is a rare inherited disease. In most HAE-affected subjects, defined trigger factors precede angioedema attacks. Mechanisms of how trigger factors stimulate the contact activation pathway with bradykinin generation ar...
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| Format: | Article |
| Language: | English |
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BMC
2018-06-01
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| Series: | Orphanet Journal of Rare Diseases |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13023-018-0832-4 |
| _version_ | 1811201426277269504 |
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| author | Urs C. Steiner Lea Kölliker Christina Weber-Chrysochoou Peter Schmid-Grendelmeier Elsbeth Probst Walter A. Wuillemin Arthur Helbling |
| author_facet | Urs C. Steiner Lea Kölliker Christina Weber-Chrysochoou Peter Schmid-Grendelmeier Elsbeth Probst Walter A. Wuillemin Arthur Helbling |
| author_sort | Urs C. Steiner |
| collection | DOAJ |
| description | Abstract Background Hereditary angioedema with C1 inhibitor deficiency (C1-INH-HAE) is a rare inherited disease. In most HAE-affected subjects, defined trigger factors precede angioedema attacks. Mechanisms of how trigger factors stimulate the contact activation pathway with bradykinin generation are not well elucidated. In recent studies, hypersensitivity reactions and food were stated as relevant triggers. We investigated HAE affected people for possible hypersensitivity reactions or intolerances and their relation in triggering angioedema attacks. Methods A questionnaire was filled in, recording date of birth, gender, and self-reported angioedema attacks associated with the ingestion of foodstuffs, administration of drugs, hymenoptera stings and hypersensitivity reactions against inhalation allergens. All participants performed a skin prick test against inhalation allergens and food. In patients who stated an association of possible hypersensitivity with angioedema, a serological ImmunoCAP test was also performed. Results From the 27 women and 15 men analyzed, 79% stated trigger factors. From those food was mentioned in 36%. The suspected food included tomato, green salad, fish, citrus fruits, apple, onion, garlic, cheese, chili, kiwi, milk, tree nuts, strawberry, pineapple, shrimps, bread, banana, leek, chicken and alcohol, and were associated with abdominal angioedema. Neither the skin prick test nor the ImmunoCAP-test turned out positive for the tested food allergens. Conclusion Food seems to be a relevant trigger factor, causing angioedema in HAE affected patients. The reason, however, is not IgE-mediated hypersensitivity, but most probably an intolerance reaction to food products. |
| first_indexed | 2024-04-12T02:21:32Z |
| format | Article |
| id | doaj.art-bc272b6e92cf49c2a1bba3acf8572198 |
| institution | Directory Open Access Journal |
| issn | 1750-1172 |
| language | English |
| last_indexed | 2024-04-12T02:21:32Z |
| publishDate | 2018-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Orphanet Journal of Rare Diseases |
| spelling | doaj.art-bc272b6e92cf49c2a1bba3acf85721982022-12-22T03:52:07ZengBMCOrphanet Journal of Rare Diseases1750-11722018-06-011311810.1186/s13023-018-0832-4Food as a trigger for abdominal angioedema attacks in patients with hereditary angioedemaUrs C. Steiner0Lea Kölliker1Christina Weber-Chrysochoou2Peter Schmid-Grendelmeier3Elsbeth Probst4Walter A. Wuillemin5Arthur Helbling6Department of Clinical Immunology, University Hospital ZurichDepartment of Clinical Immunology, University Hospital ZurichAllergy Unit, Department of Dermatology, University Hospital ZurichAllergy Unit, Department of Dermatology, University Hospital ZurichDepartment of Clinical Immunology, University Hospital ZurichDivision of Haematology and Central Haematology Laboratory, Department of Internal Medicine, Cantonal Hospital Lucerne and University of BerneDivision of Allergology, Department of Rheumatology,Immunology and Allergology, University Hospital BerneAbstract Background Hereditary angioedema with C1 inhibitor deficiency (C1-INH-HAE) is a rare inherited disease. In most HAE-affected subjects, defined trigger factors precede angioedema attacks. Mechanisms of how trigger factors stimulate the contact activation pathway with bradykinin generation are not well elucidated. In recent studies, hypersensitivity reactions and food were stated as relevant triggers. We investigated HAE affected people for possible hypersensitivity reactions or intolerances and their relation in triggering angioedema attacks. Methods A questionnaire was filled in, recording date of birth, gender, and self-reported angioedema attacks associated with the ingestion of foodstuffs, administration of drugs, hymenoptera stings and hypersensitivity reactions against inhalation allergens. All participants performed a skin prick test against inhalation allergens and food. In patients who stated an association of possible hypersensitivity with angioedema, a serological ImmunoCAP test was also performed. Results From the 27 women and 15 men analyzed, 79% stated trigger factors. From those food was mentioned in 36%. The suspected food included tomato, green salad, fish, citrus fruits, apple, onion, garlic, cheese, chili, kiwi, milk, tree nuts, strawberry, pineapple, shrimps, bread, banana, leek, chicken and alcohol, and were associated with abdominal angioedema. Neither the skin prick test nor the ImmunoCAP-test turned out positive for the tested food allergens. Conclusion Food seems to be a relevant trigger factor, causing angioedema in HAE affected patients. The reason, however, is not IgE-mediated hypersensitivity, but most probably an intolerance reaction to food products.http://link.springer.com/article/10.1186/s13023-018-0832-4Hereditary angioedema (HAE)Trigger factorsAllergyIntolerance |
| spellingShingle | Urs C. Steiner Lea Kölliker Christina Weber-Chrysochoou Peter Schmid-Grendelmeier Elsbeth Probst Walter A. Wuillemin Arthur Helbling Food as a trigger for abdominal angioedema attacks in patients with hereditary angioedema Orphanet Journal of Rare Diseases Hereditary angioedema (HAE) Trigger factors Allergy Intolerance |
| title | Food as a trigger for abdominal angioedema attacks in patients with hereditary angioedema |
| title_full | Food as a trigger for abdominal angioedema attacks in patients with hereditary angioedema |
| title_fullStr | Food as a trigger for abdominal angioedema attacks in patients with hereditary angioedema |
| title_full_unstemmed | Food as a trigger for abdominal angioedema attacks in patients with hereditary angioedema |
| title_short | Food as a trigger for abdominal angioedema attacks in patients with hereditary angioedema |
| title_sort | food as a trigger for abdominal angioedema attacks in patients with hereditary angioedema |
| topic | Hereditary angioedema (HAE) Trigger factors Allergy Intolerance |
| url | http://link.springer.com/article/10.1186/s13023-018-0832-4 |
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