Absorption and Metabolism of the Natural Sweeteners Erythritol and Xylitol in Humans: A Dose-Ranging Study
The natural sweeteners erythritol and xylitol might be helpful to reduce sugar consumption and therefore prevent obesity and diabetes. The aim of the present study was to determine the absorption and metabolization into erythronate of different concentrations of erythritol and xylitol. Seventeen hea...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-08-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/17/9867 |
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| author | Valentine Bordier Fabienne Teysseire Frank Senner Götz Schlotterbeck Jürgen Drewe Christoph Beglinger Bettina K. Wölnerhanssen Anne Christin Meyer-Gerspach |
| author_facet | Valentine Bordier Fabienne Teysseire Frank Senner Götz Schlotterbeck Jürgen Drewe Christoph Beglinger Bettina K. Wölnerhanssen Anne Christin Meyer-Gerspach |
| author_sort | Valentine Bordier |
| collection | DOAJ |
| description | The natural sweeteners erythritol and xylitol might be helpful to reduce sugar consumption and therefore prevent obesity and diabetes. The aim of the present study was to determine the absorption and metabolization into erythronate of different concentrations of erythritol and xylitol. Seventeen healthy lean participants received intragastric solutions of 10, 25, or 50 g erythritol or 7, 17, or 35 g xylitol on three study days in a randomized order. The study was double blinded with respect to the doses administered. We assessed plasma concentrations of erythritol, xylitol, and erythronate at fixed time intervals after administration with gas chromatography-mass spectrometry. We found: (i) a dose-dependent and saturable absorption of erythritol, (ii) a very low absorption of xylitol, (iii) a dose-dependent metabolization of erythritol into erythronate, and (iv) no metabolization of xylitol into erythronate. The implications of the metabolization of erythritol into erythronate for human health remain to be determined and more research in this area is needed. |
| first_indexed | 2024-03-10T01:44:34Z |
| format | Article |
| id | doaj.art-bc2765af49bb45afac45a8e9c1cbf1c5 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T01:44:34Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-bc2765af49bb45afac45a8e9c1cbf1c52023-11-23T13:18:33ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-08-012317986710.3390/ijms23179867Absorption and Metabolism of the Natural Sweeteners Erythritol and Xylitol in Humans: A Dose-Ranging StudyValentine Bordier0Fabienne Teysseire1Frank Senner2Götz Schlotterbeck3Jürgen Drewe4Christoph Beglinger5Bettina K. Wölnerhanssen6Anne Christin Meyer-Gerspach7St. Clara Research Ltd., St. Claraspital, 4002 Basel, SwitzerlandSt. Clara Research Ltd., St. Claraspital, 4002 Basel, SwitzerlandInstitute for Chemistry and Bioanalytics, School of Life Science, FHNW University of Applied Sciences and Arts Northwestern Switzerland, 4132 Muttenz, SwitzerlandInstitute for Chemistry and Bioanalytics, School of Life Science, FHNW University of Applied Sciences and Arts Northwestern Switzerland, 4132 Muttenz, SwitzerlandDepartment of Clinical Pharmacology and Toxicology, University Hospital Basel, 4001 Basel, SwitzerlandSt. Clara Research Ltd., St. Claraspital, 4002 Basel, SwitzerlandSt. Clara Research Ltd., St. Claraspital, 4002 Basel, SwitzerlandSt. Clara Research Ltd., St. Claraspital, 4002 Basel, SwitzerlandThe natural sweeteners erythritol and xylitol might be helpful to reduce sugar consumption and therefore prevent obesity and diabetes. The aim of the present study was to determine the absorption and metabolization into erythronate of different concentrations of erythritol and xylitol. Seventeen healthy lean participants received intragastric solutions of 10, 25, or 50 g erythritol or 7, 17, or 35 g xylitol on three study days in a randomized order. The study was double blinded with respect to the doses administered. We assessed plasma concentrations of erythritol, xylitol, and erythronate at fixed time intervals after administration with gas chromatography-mass spectrometry. We found: (i) a dose-dependent and saturable absorption of erythritol, (ii) a very low absorption of xylitol, (iii) a dose-dependent metabolization of erythritol into erythronate, and (iv) no metabolization of xylitol into erythronate. The implications of the metabolization of erythritol into erythronate for human health remain to be determined and more research in this area is needed.https://www.mdpi.com/1422-0067/23/17/9867erythritolxylitolerythronatenatural sweetenersabsorptionmetabolism |
| spellingShingle | Valentine Bordier Fabienne Teysseire Frank Senner Götz Schlotterbeck Jürgen Drewe Christoph Beglinger Bettina K. Wölnerhanssen Anne Christin Meyer-Gerspach Absorption and Metabolism of the Natural Sweeteners Erythritol and Xylitol in Humans: A Dose-Ranging Study International Journal of Molecular Sciences erythritol xylitol erythronate natural sweeteners absorption metabolism |
| title | Absorption and Metabolism of the Natural Sweeteners Erythritol and Xylitol in Humans: A Dose-Ranging Study |
| title_full | Absorption and Metabolism of the Natural Sweeteners Erythritol and Xylitol in Humans: A Dose-Ranging Study |
| title_fullStr | Absorption and Metabolism of the Natural Sweeteners Erythritol and Xylitol in Humans: A Dose-Ranging Study |
| title_full_unstemmed | Absorption and Metabolism of the Natural Sweeteners Erythritol and Xylitol in Humans: A Dose-Ranging Study |
| title_short | Absorption and Metabolism of the Natural Sweeteners Erythritol and Xylitol in Humans: A Dose-Ranging Study |
| title_sort | absorption and metabolism of the natural sweeteners erythritol and xylitol in humans a dose ranging study |
| topic | erythritol xylitol erythronate natural sweeteners absorption metabolism |
| url | https://www.mdpi.com/1422-0067/23/17/9867 |
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