The Number and Position of Orai3 Units within Heteromeric Store-Operated Ca<sup>2+</sup> Channels Alter the Pharmacology of I<sub>CRAC</sub>

The Number and Position of Orai3 Units within Heteromeric Store-Operated Ca<sup>2+</sup> Channels Alter the Pharmacology of I<sub>CRAC</sub>

Store-operated heteromeric Orai1/Orai3 channels have been discussed in the context of aging, cancer, and immune cell differentiation. In contrast to homomeric Orai1 channels, they exhibit a different pharmacology upon application of reactive oxygen species (ROS) or 2-aminoethoxydiphenyl borate (2-AP...

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Bibliographic Details
Main Authors: Sven Kappel, Tatiana Kilch, Roland Baur, Martin Lochner, Christine Peinelt
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:International Journal of Molecular Sciences
Subjects:
Orai1
Orai3
concatenated channels
I<sub>CRAC</sub>
SOCE
2-APB
Online Access:https://www.mdpi.com/1422-0067/21/7/2458

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