The role of PI3K/Akt signalling pathway in spinal cord injury
Spinal cord injury (SCI) is a severely disabling central nervous system injury with complex pathological mechanisms that leads to sensory and motor dysfunction. The current treatment for SCI is aimed at symptomatic symptom relief rather than the pathological causes. Several studies have reported tha...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-12-01
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| Series: | Biomedicine & Pharmacotherapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0753332222012707 |
| _version_ | 1811180052242497536 |
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| author | Chun-Lin Xiao Wen-Chao Yin Yan-Chun Zhong Jia-Quan Luo Lu-Lin Liu Wu-Yang Liu Kai Zhao |
| author_facet | Chun-Lin Xiao Wen-Chao Yin Yan-Chun Zhong Jia-Quan Luo Lu-Lin Liu Wu-Yang Liu Kai Zhao |
| author_sort | Chun-Lin Xiao |
| collection | DOAJ |
| description | Spinal cord injury (SCI) is a severely disabling central nervous system injury with complex pathological mechanisms that leads to sensory and motor dysfunction. The current treatment for SCI is aimed at symptomatic symptom relief rather than the pathological causes. Several studies have reported that signaling pathways play a key role in SCI pathological processes and neuronal recovery mechanisms. The PI3K/Akt signaling pathway is an important pathway closely related to the pathological process of SCI, and activation of this pathway can delay the inflammatory response, prevent glial scar formation, and promote neurological function recovery. Activation of this pathway can promote the recovery of neurological function after SCI by reducing cell apoptosis. Based on the role of the PI3K/Akt pathway in SCI, it may be a potential therapeutic target. This review highlights the role of activating or inhibiting the PI3K/Akt signaling pathway in SCI-induced inflammatory response, apoptosis, autophagy, and glial scar formation. We also summarize the latest evidence on treating SCI by targeting the PI3K/Akt pathway, discuss the shortcomings and deficiencies of PI3K/Akt research in the field of SCI, and identify potential challenges in developing these clinical therapeutic SCI strategies, and provide appropriate solutions. |
| first_indexed | 2024-04-11T06:44:55Z |
| format | Article |
| id | doaj.art-bc293b1784f44caba04fc7a6d805c052 |
| institution | Directory Open Access Journal |
| issn | 0753-3322 |
| language | English |
| last_indexed | 2024-04-11T06:44:55Z |
| publishDate | 2022-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedicine & Pharmacotherapy |
| spelling | doaj.art-bc293b1784f44caba04fc7a6d805c0522022-12-22T04:39:23ZengElsevierBiomedicine & Pharmacotherapy0753-33222022-12-01156113881The role of PI3K/Akt signalling pathway in spinal cord injuryChun-Lin Xiao0Wen-Chao Yin1Yan-Chun Zhong2Jia-Quan Luo3Lu-Lin Liu4Wu-Yang Liu5Kai Zhao6Gannan Medical University, Ganzhou 341000, PR China; Department of Orthopaedics, Frist Affiliated Hospital of Gannan Medical University, Ganzhou 341000, PR ChinaGannan Medical University, Ganzhou 341000, PR China; Department of Orthopaedics, Frist Affiliated Hospital of Gannan Medical University, Ganzhou 341000, PR ChinaGannan Medical University, Ganzhou 341000, PR China; Department of Orthopaedics, Frist Affiliated Hospital of Gannan Medical University, Ganzhou 341000, PR ChinaGannan Medical University, Ganzhou 341000, PR China; Department of Orthopaedics, Frist Affiliated Hospital of Gannan Medical University, Ganzhou 341000, PR ChinaGannan Medical University, Ganzhou 341000, PR China; Department of Orthopaedics, Frist Affiliated Hospital of Gannan Medical University, Ganzhou 341000, PR ChinaGannan Medical University, Ganzhou 341000, PR China; Department of Orthopaedics, Frist Affiliated Hospital of Gannan Medical University, Ganzhou 341000, PR China; Corresponding authors at: Gannan Medical University, Ganzhou 341000, PR China.Gannan Medical University, Ganzhou 341000, PR China; Department of Orthopaedics, Frist Affiliated Hospital of Gannan Medical University, Ganzhou 341000, PR China; Corresponding authors at: Gannan Medical University, Ganzhou 341000, PR China.Spinal cord injury (SCI) is a severely disabling central nervous system injury with complex pathological mechanisms that leads to sensory and motor dysfunction. The current treatment for SCI is aimed at symptomatic symptom relief rather than the pathological causes. Several studies have reported that signaling pathways play a key role in SCI pathological processes and neuronal recovery mechanisms. The PI3K/Akt signaling pathway is an important pathway closely related to the pathological process of SCI, and activation of this pathway can delay the inflammatory response, prevent glial scar formation, and promote neurological function recovery. Activation of this pathway can promote the recovery of neurological function after SCI by reducing cell apoptosis. Based on the role of the PI3K/Akt pathway in SCI, it may be a potential therapeutic target. This review highlights the role of activating or inhibiting the PI3K/Akt signaling pathway in SCI-induced inflammatory response, apoptosis, autophagy, and glial scar formation. We also summarize the latest evidence on treating SCI by targeting the PI3K/Akt pathway, discuss the shortcomings and deficiencies of PI3K/Akt research in the field of SCI, and identify potential challenges in developing these clinical therapeutic SCI strategies, and provide appropriate solutions.http://www.sciencedirect.com/science/article/pii/S0753332222012707Spinal cord injury (SCI)PI3KAktTherapeutic targetMechanism |
| spellingShingle | Chun-Lin Xiao Wen-Chao Yin Yan-Chun Zhong Jia-Quan Luo Lu-Lin Liu Wu-Yang Liu Kai Zhao The role of PI3K/Akt signalling pathway in spinal cord injury Biomedicine & Pharmacotherapy Spinal cord injury (SCI) PI3K Akt Therapeutic target Mechanism |
| title | The role of PI3K/Akt signalling pathway in spinal cord injury |
| title_full | The role of PI3K/Akt signalling pathway in spinal cord injury |
| title_fullStr | The role of PI3K/Akt signalling pathway in spinal cord injury |
| title_full_unstemmed | The role of PI3K/Akt signalling pathway in spinal cord injury |
| title_short | The role of PI3K/Akt signalling pathway in spinal cord injury |
| title_sort | role of pi3k akt signalling pathway in spinal cord injury |
| topic | Spinal cord injury (SCI) PI3K Akt Therapeutic target Mechanism |
| url | http://www.sciencedirect.com/science/article/pii/S0753332222012707 |
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