Aspirin resistance in patients with ischemic stroke
INTRODUCTION[|]Aspirin is the basic agent of antithrombotic treatment in ischemic cerebrovascular disease (CVD) patients. However several patients don't respond to treatment and therefore aspirin resistance term has been used lately. Recent studies have shown that aspirin resistance incidence i...
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| Format: | Article |
| Language: | English |
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KARE Publishing
2019-01-01
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| Series: | Southern Clinics of Istanbul Eurasia |
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| Online Access: | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=scie&un=SCIE-40427 |
| _version_ | 1797920816887758848 |
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| author | Anıl Bulut Sultan Çağırıcı Vildan Yayla Murat Çabalar Songül Şenadım |
| author_facet | Anıl Bulut Sultan Çağırıcı Vildan Yayla Murat Çabalar Songül Şenadım |
| author_sort | Anıl Bulut |
| collection | DOAJ |
| description | INTRODUCTION[|]Aspirin is the basic agent of antithrombotic treatment in ischemic cerebrovascular disease (CVD) patients. However several patients don't respond to treatment and therefore aspirin resistance term has been used lately. Recent studies have shown that aspirin resistance incidence is between 3-85% among CVD patients. In this study, we aimed to determine the frequency of aspirin resistance in CVD and their relationship with demographic characteristics, risk factors, and stroke subtypes were evaluated. [¤]METHODS[|]In a 6 months period 163 (106 Male-57 Female) acute ischemic stroke patients followed-up and treated with aspirin (100mg-300mg daily) were evaluated. Aspirin resistance was measured by a Multiplate® platelet analyser. Correlation between aspirin resistance and stroke subtypes, age, sex, weight, height, hypertension (HT), diabetes mellitus (DM), history of CVD, smoking, alcohol, hyperlipidemia (HL) and fasting blood glucose level were analyzed.[¤]RESULTS[|]Aspirin resistance was found in 16 male, 9 female, totally 25 (15.3%) of 163 patients. There was no statistically significant relationship between aspirin resistance and stroke-related clinical and laboratory parameters.[¤]DISCUSSION AND CONCLUSION[|]Our results needed to be confirmed with larger prospective trials in order to clarify which of the patients with ischemic stroke should be tested and how to treat the patients with resistance.[¤] |
| first_indexed | 2024-04-10T14:06:54Z |
| format | Article |
| id | doaj.art-bc29c2f9ab334e2aaa8189d771d84b0f |
| institution | Directory Open Access Journal |
| issn | 2587-0998 |
| language | English |
| last_indexed | 2024-04-10T14:06:54Z |
| publishDate | 2019-01-01 |
| publisher | KARE Publishing |
| record_format | Article |
| series | Southern Clinics of Istanbul Eurasia |
| spelling | doaj.art-bc29c2f9ab334e2aaa8189d771d84b0f2023-02-15T16:09:57ZengKARE PublishingSouthern Clinics of Istanbul Eurasia2587-09982019-01-0129422522910.14744/scie.2018.40427SCIE-40427Aspirin resistance in patients with ischemic strokeAnıl Bulut0Sultan Çağırıcı1Vildan Yayla2Murat Çabalar3Songül Şenadım4Department of Neurology, University of Health Sciences, Kartal Dr. Lütfi Kırdar Training and Research Hospital, Istanbul.Neurologist, Servergazi State Hospital, DenizliDepartment of Neurology, University of Health Sciences, Bakırköy Dr. Sadi Konuk Training and Research Hospital, Istanbul.Department of Neurology, University of Health Sciences, Bakırköy Dr. Sadi Konuk Training and Research Hospital, Istanbul.Department of Neurology, University of Health Sciences, Bakırköy Prof. Dr. Mazhar Osman Mental Health and Disorders Training and Research Hospital, Istanbul.INTRODUCTION[|]Aspirin is the basic agent of antithrombotic treatment in ischemic cerebrovascular disease (CVD) patients. However several patients don't respond to treatment and therefore aspirin resistance term has been used lately. Recent studies have shown that aspirin resistance incidence is between 3-85% among CVD patients. In this study, we aimed to determine the frequency of aspirin resistance in CVD and their relationship with demographic characteristics, risk factors, and stroke subtypes were evaluated. [¤]METHODS[|]In a 6 months period 163 (106 Male-57 Female) acute ischemic stroke patients followed-up and treated with aspirin (100mg-300mg daily) were evaluated. Aspirin resistance was measured by a Multiplate® platelet analyser. Correlation between aspirin resistance and stroke subtypes, age, sex, weight, height, hypertension (HT), diabetes mellitus (DM), history of CVD, smoking, alcohol, hyperlipidemia (HL) and fasting blood glucose level were analyzed.[¤]RESULTS[|]Aspirin resistance was found in 16 male, 9 female, totally 25 (15.3%) of 163 patients. There was no statistically significant relationship between aspirin resistance and stroke-related clinical and laboratory parameters.[¤]DISCUSSION AND CONCLUSION[|]Our results needed to be confirmed with larger prospective trials in order to clarify which of the patients with ischemic stroke should be tested and how to treat the patients with resistance.[¤]https://jag.journalagent.com/z4/download_fulltext.asp?pdir=scie&un=SCIE-40427ischemic strokeaspirin resistancemultiplate analyzer |
| spellingShingle | Anıl Bulut Sultan Çağırıcı Vildan Yayla Murat Çabalar Songül Şenadım Aspirin resistance in patients with ischemic stroke Southern Clinics of Istanbul Eurasia ischemic stroke aspirin resistance multiplate analyzer |
| title | Aspirin resistance in patients with ischemic stroke |
| title_full | Aspirin resistance in patients with ischemic stroke |
| title_fullStr | Aspirin resistance in patients with ischemic stroke |
| title_full_unstemmed | Aspirin resistance in patients with ischemic stroke |
| title_short | Aspirin resistance in patients with ischemic stroke |
| title_sort | aspirin resistance in patients with ischemic stroke |
| topic | ischemic stroke aspirin resistance multiplate analyzer |
| url | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=scie&un=SCIE-40427 |
| work_keys_str_mv | AT anılbulut aspirinresistanceinpatientswithischemicstroke AT sultancagırıcı aspirinresistanceinpatientswithischemicstroke AT vildanyayla aspirinresistanceinpatientswithischemicstroke AT muratcabalar aspirinresistanceinpatientswithischemicstroke AT songulsenadım aspirinresistanceinpatientswithischemicstroke |