Morphine suppresses peripheral responses and transforms brain myeloid gene expression to favor neuropathogenesis in SIV infection

Morphine suppresses peripheral responses and transforms brain myeloid gene expression to favor neuropathogenesis in SIV infection

The twin pandemics of opioid abuse and HIV infection can have devastating effects on physiological systems, including on the brain. Our previous work found that morphine increased the viral reservoir in the brains of treated SIV-infected macaques. In this study, we investigated the interaction of mo...

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Bibliographic Details
Main Authors: Howard S. Fox, Meng Niu, Brenda M. Morsey, Benjamin G. Lamberty, Katy Emanuel, Palsamy Periyasamy, Shannon Callen, Arpan Acharya, Gregory Kubik, James Eudy, Chittibabu Guda, Shetty Ravi Dyavar, Courtney V. Fletcher, Siddappa N. Byrareddy, Shilpa Buch
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Immunology
Subjects:
neuroHIV
microglia
HIV
SIV
opioid
opiate
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1012884/full

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