Effects of dietary supplementation with milk fat globule membrane on the physical performance of community-dwelling Japanese adults: a randomised, double-blind, placebo-controlled trial
We conducted a randomised, double-blind, placebo-controlled trial to elucidate the effects of dietary milk fat globule membrane (MFGM) on the physical performance of community-dwelling Japanese adults. For this 24-week study, 115 middle-aged subjects (range 50–70 years old) were invited, of whom 113...
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| Format: | Article |
| Language: | English |
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Cambridge University Press
2018-01-01
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| Series: | Journal of Nutritional Science |
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| Online Access: | https://www.cambridge.org/core/product/identifier/S2048679018000083/type/journal_article |
| _version_ | 1811155939433119744 |
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| author | Yasuo Kokai Nana Mikami Mitsuhiro Tada Kazuichi Tomonobu Ryuji Ochiai Noriko Osaki Yoshihisa Katsuragi Hitoshi Sohma Yoichi M. Ito |
| author_facet | Yasuo Kokai Nana Mikami Mitsuhiro Tada Kazuichi Tomonobu Ryuji Ochiai Noriko Osaki Yoshihisa Katsuragi Hitoshi Sohma Yoichi M. Ito |
| author_sort | Yasuo Kokai |
| collection | DOAJ |
| description | We conducted a randomised, double-blind, placebo-controlled trial to elucidate the effects of dietary milk fat globule membrane (MFGM) on the physical performance of community-dwelling Japanese adults. For this 24-week study, 115 middle-aged subjects (range 50–70 years old) were invited, of whom 113 (seventy-two women, forty-one men) completed the trial. Participants were then divided into either the placebo control or MFGM group. Measurements of physical performance (without undertaking any mandatory exercise) examining muscle strength, agility and balance were tested every 6 weeks until 24 weeks. Analyses were performed using the intention-to-treat method for all participants. Although the effects of MFGM on muscle strength and agility were not significant, we noted that the parameter for balance (such as the ability to stand on one leg with eyes closed for longer durations) increased in the MFGM group (mean 10·1 (95 % CI 8·25, 12·4) s) compared with the placebo (mean 7·53 (95 % CI 6·11, 9·30) s) (P = 0·046). Similarly, application of the mixed-effect model for repeated measures under unstructured covariance also revealed that the effect of MFGM was significant when compared with the placebo (10·2 (95 % CI 8·33, 12·4) v. 7·61 (95 % CI 6·17, 9·30) s) (P = 0·045). In conclusion, we demonstrated that MFGM had an effect on the physical performance of community-dwelling Japanese adults despite mandatory exercise. However, studies using larger cohorts of individuals from different demographic backgrounds are required to further elucidate the mechanisms underlying these effects and to extend the application of MFGM. |
| first_indexed | 2024-04-10T04:42:07Z |
| format | Article |
| id | doaj.art-bc2c9c211b9b4271a8dda277160ffd2d |
| institution | Directory Open Access Journal |
| issn | 2048-6790 |
| language | English |
| last_indexed | 2024-04-10T04:42:07Z |
| publishDate | 2018-01-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | Journal of Nutritional Science |
| spelling | doaj.art-bc2c9c211b9b4271a8dda277160ffd2d2023-03-09T12:38:59ZengCambridge University PressJournal of Nutritional Science2048-67902018-01-01710.1017/jns.2018.8Effects of dietary supplementation with milk fat globule membrane on the physical performance of community-dwelling Japanese adults: a randomised, double-blind, placebo-controlled trialYasuo Kokai0Nana Mikami1Mitsuhiro Tada2Kazuichi Tomonobu3Ryuji Ochiai4Noriko Osaki5Yoshihisa Katsuragi6Hitoshi Sohma7Yoichi M. Ito8Department of Biomedical Engineering, Sapporo Medical University School of Medicine, S1W17, Chuo-ku, Sapporo, JapanDepartment of Biomedical Engineering, Sapporo Medical University School of Medicine, S1W17, Chuo-ku, Sapporo, JapanDepartment of Neurosurgery, Rumoi Municipal Hospital, 2-16-1 Shinonome, Rumoi, JapanHealth Care Food Research Laboratory, Kao Corporation, Tachibana-2-1-3, Sumida-ku, Tokyo, JapanHealth Care Food Research Laboratory, Kao Corporation, Tachibana-2-1-3, Sumida-ku, Tokyo, JapanHealth Care Food Research Laboratory, Kao Corporation, Tachibana-2-1-3, Sumida-ku, Tokyo, JapanHealth Care Food Research Laboratory, Kao Corporation, Tachibana-2-1-3, Sumida-ku, Tokyo, JapanDepartment of Educational Development, Sapporo Medical University Center for Medical Education, S1W17, Chuo-ku, Sapporo, JapanDepartment of Biostatics, Hokkaido University Graduate School of Medicine, N15W7, Kita-ku, Sapporo, JapanWe conducted a randomised, double-blind, placebo-controlled trial to elucidate the effects of dietary milk fat globule membrane (MFGM) on the physical performance of community-dwelling Japanese adults. For this 24-week study, 115 middle-aged subjects (range 50–70 years old) were invited, of whom 113 (seventy-two women, forty-one men) completed the trial. Participants were then divided into either the placebo control or MFGM group. Measurements of physical performance (without undertaking any mandatory exercise) examining muscle strength, agility and balance were tested every 6 weeks until 24 weeks. Analyses were performed using the intention-to-treat method for all participants. Although the effects of MFGM on muscle strength and agility were not significant, we noted that the parameter for balance (such as the ability to stand on one leg with eyes closed for longer durations) increased in the MFGM group (mean 10·1 (95 % CI 8·25, 12·4) s) compared with the placebo (mean 7·53 (95 % CI 6·11, 9·30) s) (P = 0·046). Similarly, application of the mixed-effect model for repeated measures under unstructured covariance also revealed that the effect of MFGM was significant when compared with the placebo (10·2 (95 % CI 8·33, 12·4) v. 7·61 (95 % CI 6·17, 9·30) s) (P = 0·045). In conclusion, we demonstrated that MFGM had an effect on the physical performance of community-dwelling Japanese adults despite mandatory exercise. However, studies using larger cohorts of individuals from different demographic backgrounds are required to further elucidate the mechanisms underlying these effects and to extend the application of MFGM.https://www.cambridge.org/core/product/identifier/S2048679018000083/type/journal_articlePhysical performanceOne-leg standBalanceAgilityAgeingMilk fat globule membrane |
| spellingShingle | Yasuo Kokai Nana Mikami Mitsuhiro Tada Kazuichi Tomonobu Ryuji Ochiai Noriko Osaki Yoshihisa Katsuragi Hitoshi Sohma Yoichi M. Ito Effects of dietary supplementation with milk fat globule membrane on the physical performance of community-dwelling Japanese adults: a randomised, double-blind, placebo-controlled trial Journal of Nutritional Science Physical performance One-leg stand Balance Agility Ageing Milk fat globule membrane |
| title | Effects of dietary supplementation with milk fat globule membrane on the physical performance of community-dwelling Japanese adults: a randomised, double-blind, placebo-controlled trial |
| title_full | Effects of dietary supplementation with milk fat globule membrane on the physical performance of community-dwelling Japanese adults: a randomised, double-blind, placebo-controlled trial |
| title_fullStr | Effects of dietary supplementation with milk fat globule membrane on the physical performance of community-dwelling Japanese adults: a randomised, double-blind, placebo-controlled trial |
| title_full_unstemmed | Effects of dietary supplementation with milk fat globule membrane on the physical performance of community-dwelling Japanese adults: a randomised, double-blind, placebo-controlled trial |
| title_short | Effects of dietary supplementation with milk fat globule membrane on the physical performance of community-dwelling Japanese adults: a randomised, double-blind, placebo-controlled trial |
| title_sort | effects of dietary supplementation with milk fat globule membrane on the physical performance of community dwelling japanese adults a randomised double blind placebo controlled trial |
| topic | Physical performance One-leg stand Balance Agility Ageing Milk fat globule membrane |
| url | https://www.cambridge.org/core/product/identifier/S2048679018000083/type/journal_article |
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