IgM anti-malondialdehyde low density lipoprotein antibody levels indicate coronary heart disease and necrotic core characteristics in the Nordic Diltiazem (NORDIL) study and the Integrated Imaging and Biomarker Study 3 (IBIS-3)Research in Context
Background: Certain immunoglobulins (Ig) are proposed to have protective functions in atherosclerosis. Objectives: We tested whether serum levels of IgG and IgM autoantibodies against malondialdehyde low density lipoprotein (MDA-LDL) are associated with clinical coronary heart disease (CHD) and unfa...
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| Format: | Article |
| Language: | English |
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Elsevier
2018-10-01
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| Series: | EBioMedicine |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352396418303098 |
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| author | Victor J. van den Berg Dorian O. Haskard Artur Fedorowski Adam Hartley Isabella Kardys Mikhail Caga-Anan K. Martijn Akkerhuis Rohit M. Oemrawsingh Robert Jan van Geuns Peter de Jaegere Nicolas van Mieghem Evelyn Regar Jurgen M.R. Ligthart Victor A.W.M. Umans Patrick W. Serruys Olle Melander Eric Boersma Ramzi Y. Khamis |
| author_facet | Victor J. van den Berg Dorian O. Haskard Artur Fedorowski Adam Hartley Isabella Kardys Mikhail Caga-Anan K. Martijn Akkerhuis Rohit M. Oemrawsingh Robert Jan van Geuns Peter de Jaegere Nicolas van Mieghem Evelyn Regar Jurgen M.R. Ligthart Victor A.W.M. Umans Patrick W. Serruys Olle Melander Eric Boersma Ramzi Y. Khamis |
| author_sort | Victor J. van den Berg |
| collection | DOAJ |
| description | Background: Certain immunoglobulins (Ig) are proposed to have protective functions in atherosclerosis. Objectives: We tested whether serum levels of IgG and IgM autoantibodies against malondialdehyde low density lipoprotein (MDA-LDL) are associated with clinical coronary heart disease (CHD) and unfavorable plaque characteristics. Methods: NORDIL was a prospective study investigating adverse cardiovascular outcomes in hypertensive patients. IBIS-3 analyzed lesions in a non-culprit coronary artery with <50% stenosis using radiofrequency intravascular ultrasound (RF-IVUS) and near-infrared spectroscopy (NIRS). Imaging was repeated after a median of 386 days on rosuvastatin. Associations of antibodies with incident CHD and imaging parameters were assessed in the two sub-studies respectively. Findings: From 10,881 NORDIL patients, 87 had serum sampled at baseline and developed CHD over 4.5 years, matched to 227 controls. Higher titers of IgM anti-MDA-LDL had a protective effect on adverse outcomes, with odds ratio 0.29 (0.11, 0.76; p = 0.012; p = 0.016 for trend). Therefore, the effect was explored at the lesional level in IBIS-3. 143 patients had blood samples and RF-IVUS measurements available, and NIRS was performed in 90 of these. At baseline, IgM anti-MDA-LDL levels had a strong independent inverse relationship with lesional necrotic core volume (p = 0.027) and percentage of plaque occupied by necrotic core (p = 0.011), as well as lipid core burden index (p = 0.024) in the worst 4 mm segment. Interpretation: Our study supports the hypothesis that lower circulating levels of IgM anti-MDA-LDL are associated with clinical CHD development, and for the first time relates these findings to atherosclerotic plaque characteristics that are linked to vulnerability. Keywords: Necrotic core, Lipid core, Oxidized low density lipoprotein, Immunoglobulins, Near-infrared spectroscopy, Intravascular ultrasound |
| first_indexed | 2024-12-13T05:42:24Z |
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| institution | Directory Open Access Journal |
| issn | 2352-3964 |
| language | English |
| last_indexed | 2024-12-13T05:42:24Z |
| publishDate | 2018-10-01 |
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| spelling | doaj.art-bc2cf4d126cf4ab6a9f0b3912d2109182022-12-21T23:57:46ZengElsevierEBioMedicine2352-39642018-10-01366372IgM anti-malondialdehyde low density lipoprotein antibody levels indicate coronary heart disease and necrotic core characteristics in the Nordic Diltiazem (NORDIL) study and the Integrated Imaging and Biomarker Study 3 (IBIS-3)Research in ContextVictor J. van den Berg0Dorian O. Haskard1Artur Fedorowski2Adam Hartley3Isabella Kardys4Mikhail Caga-Anan5K. Martijn Akkerhuis6Rohit M. Oemrawsingh7Robert Jan van Geuns8Peter de Jaegere9Nicolas van Mieghem10Evelyn Regar11Jurgen M.R. Ligthart12Victor A.W.M. Umans13Patrick W. Serruys14Olle Melander15Eric Boersma16Ramzi Y. Khamis17Department of Cardiology, Erasmus MC, Rotterdam, The Netherlands; Department of Cardiology, Northwest Clinics, Alkmaar, The Netherlands; Netherlands Heart Institute (NHI), Utrecht, The NetherlandsNational Heart and Lung Institute, Imperial College, London, United KingdomDepartment of Clinical Sciences, Malmö, Lund University, Clinical Research Center, Malmö, Sweden; Department of Cardiology, Skåne University Hospital, Malmö, SwedenNational Heart and Lung Institute, Imperial College, London, United KingdomDepartment of Cardiology, Erasmus MC, Rotterdam, The NetherlandsNational Heart and Lung Institute, Imperial College, London, United KingdomDepartment of Cardiology, Erasmus MC, Rotterdam, The NetherlandsDepartment of Cardiology, Erasmus MC, Rotterdam, The NetherlandsDepartment of Cardiology, Erasmus MC, Rotterdam, The NetherlandsDepartment of Cardiology, Erasmus MC, Rotterdam, The NetherlandsDepartment of Cardiology, Erasmus MC, Rotterdam, The NetherlandsDepartment of Cardiology, Erasmus MC, Rotterdam, The NetherlandsDepartment of Cardiology, Erasmus MC, Rotterdam, The NetherlandsDepartment of Cardiology, Northwest Clinics, Alkmaar, The NetherlandsNational Heart and Lung Institute, Imperial College, London, United KingdomDepartment of Clinical Sciences, Malmö, Lund University, Clinical Research Center, Malmö, SwedenDepartment of Cardiology, Erasmus MC, Rotterdam, The NetherlandsNational Heart and Lung Institute, Imperial College, London, United Kingdom; Corresponding author at: National Heart and Lung Institute, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 0HN, United Kingdom.Background: Certain immunoglobulins (Ig) are proposed to have protective functions in atherosclerosis. Objectives: We tested whether serum levels of IgG and IgM autoantibodies against malondialdehyde low density lipoprotein (MDA-LDL) are associated with clinical coronary heart disease (CHD) and unfavorable plaque characteristics. Methods: NORDIL was a prospective study investigating adverse cardiovascular outcomes in hypertensive patients. IBIS-3 analyzed lesions in a non-culprit coronary artery with <50% stenosis using radiofrequency intravascular ultrasound (RF-IVUS) and near-infrared spectroscopy (NIRS). Imaging was repeated after a median of 386 days on rosuvastatin. Associations of antibodies with incident CHD and imaging parameters were assessed in the two sub-studies respectively. Findings: From 10,881 NORDIL patients, 87 had serum sampled at baseline and developed CHD over 4.5 years, matched to 227 controls. Higher titers of IgM anti-MDA-LDL had a protective effect on adverse outcomes, with odds ratio 0.29 (0.11, 0.76; p = 0.012; p = 0.016 for trend). Therefore, the effect was explored at the lesional level in IBIS-3. 143 patients had blood samples and RF-IVUS measurements available, and NIRS was performed in 90 of these. At baseline, IgM anti-MDA-LDL levels had a strong independent inverse relationship with lesional necrotic core volume (p = 0.027) and percentage of plaque occupied by necrotic core (p = 0.011), as well as lipid core burden index (p = 0.024) in the worst 4 mm segment. Interpretation: Our study supports the hypothesis that lower circulating levels of IgM anti-MDA-LDL are associated with clinical CHD development, and for the first time relates these findings to atherosclerotic plaque characteristics that are linked to vulnerability. Keywords: Necrotic core, Lipid core, Oxidized low density lipoprotein, Immunoglobulins, Near-infrared spectroscopy, Intravascular ultrasoundhttp://www.sciencedirect.com/science/article/pii/S2352396418303098 |
| spellingShingle | Victor J. van den Berg Dorian O. Haskard Artur Fedorowski Adam Hartley Isabella Kardys Mikhail Caga-Anan K. Martijn Akkerhuis Rohit M. Oemrawsingh Robert Jan van Geuns Peter de Jaegere Nicolas van Mieghem Evelyn Regar Jurgen M.R. Ligthart Victor A.W.M. Umans Patrick W. Serruys Olle Melander Eric Boersma Ramzi Y. Khamis IgM anti-malondialdehyde low density lipoprotein antibody levels indicate coronary heart disease and necrotic core characteristics in the Nordic Diltiazem (NORDIL) study and the Integrated Imaging and Biomarker Study 3 (IBIS-3)Research in Context EBioMedicine |
| title | IgM anti-malondialdehyde low density lipoprotein antibody levels indicate coronary heart disease and necrotic core characteristics in the Nordic Diltiazem (NORDIL) study and the Integrated Imaging and Biomarker Study 3 (IBIS-3)Research in Context |
| title_full | IgM anti-malondialdehyde low density lipoprotein antibody levels indicate coronary heart disease and necrotic core characteristics in the Nordic Diltiazem (NORDIL) study and the Integrated Imaging and Biomarker Study 3 (IBIS-3)Research in Context |
| title_fullStr | IgM anti-malondialdehyde low density lipoprotein antibody levels indicate coronary heart disease and necrotic core characteristics in the Nordic Diltiazem (NORDIL) study and the Integrated Imaging and Biomarker Study 3 (IBIS-3)Research in Context |
| title_full_unstemmed | IgM anti-malondialdehyde low density lipoprotein antibody levels indicate coronary heart disease and necrotic core characteristics in the Nordic Diltiazem (NORDIL) study and the Integrated Imaging and Biomarker Study 3 (IBIS-3)Research in Context |
| title_short | IgM anti-malondialdehyde low density lipoprotein antibody levels indicate coronary heart disease and necrotic core characteristics in the Nordic Diltiazem (NORDIL) study and the Integrated Imaging and Biomarker Study 3 (IBIS-3)Research in Context |
| title_sort | igm anti malondialdehyde low density lipoprotein antibody levels indicate coronary heart disease and necrotic core characteristics in the nordic diltiazem nordil study and the integrated imaging and biomarker study 3 ibis 3 research in context |
| url | http://www.sciencedirect.com/science/article/pii/S2352396418303098 |
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