Bioengineered probiotics to control SARS-CoV-2 infection
The outbreak of 2019 novel corona virus disease (COVID-19) is now a global public health crisis and declared as a pandemic. Several recent studies suggest that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein binds to human angiotensin-converting enzyme 2 (ACE2). The inform...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Pensoft Publishers
2020-05-01
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| Series: | Research Ideas and Outcomes |
| Subjects: | |
| Online Access: | https://riojournal.com/article/54802/download/pdf/ |
| _version_ | 1818291629161709568 |
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| author | Shantibhusan Senapati Jayalaxmi Dash Manisha Sethi Subhankar Chakraborty |
| author_facet | Shantibhusan Senapati Jayalaxmi Dash Manisha Sethi Subhankar Chakraborty |
| author_sort | Shantibhusan Senapati |
| collection | DOAJ |
| description | The outbreak of 2019 novel corona virus disease (COVID-19) is now a global public health crisis and declared as a pandemic. Several recent studies suggest that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein binds to human angiotensin-converting enzyme 2 (ACE2). The information obtained from these structural and biochemical studies provides a strong rationale to target SARS-CoV-2 spike protein and ACE2 interaction for developing therapeutics against this viral infection. Here, we propose to discuss the scope of bioengineered probiotics expressing human ACE2 as a novel therapeutic to control the viral outbreak. |
| first_indexed | 2024-12-13T02:47:06Z |
| format | Article |
| id | doaj.art-bc2d0005ab114edf9bca786a58be7ee0 |
| institution | Directory Open Access Journal |
| issn | 2367-7163 |
| language | English |
| last_indexed | 2024-12-13T02:47:06Z |
| publishDate | 2020-05-01 |
| publisher | Pensoft Publishers |
| record_format | Article |
| series | Research Ideas and Outcomes |
| spelling | doaj.art-bc2d0005ab114edf9bca786a58be7ee02022-12-22T00:02:09ZengPensoft PublishersResearch Ideas and Outcomes2367-71632020-05-0161410.3897/rio.6.e5480254802Bioengineered probiotics to control SARS-CoV-2 infectionShantibhusan Senapati0Jayalaxmi Dash1Manisha Sethi2Subhankar Chakraborty3Institute of Life SciencesInstitute of Life SciencesInstitute of Life SciencesOhio State University Wexner Medical CenterThe outbreak of 2019 novel corona virus disease (COVID-19) is now a global public health crisis and declared as a pandemic. Several recent studies suggest that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein binds to human angiotensin-converting enzyme 2 (ACE2). The information obtained from these structural and biochemical studies provides a strong rationale to target SARS-CoV-2 spike protein and ACE2 interaction for developing therapeutics against this viral infection. Here, we propose to discuss the scope of bioengineered probiotics expressing human ACE2 as a novel therapeutic to control the viral outbreak.https://riojournal.com/article/54802/download/pdf/SARS-CoV-2ACE2probiotics |
| spellingShingle | Shantibhusan Senapati Jayalaxmi Dash Manisha Sethi Subhankar Chakraborty Bioengineered probiotics to control SARS-CoV-2 infection Research Ideas and Outcomes SARS-CoV-2 ACE2 probiotics |
| title | Bioengineered probiotics to control SARS-CoV-2 infection |
| title_full | Bioengineered probiotics to control SARS-CoV-2 infection |
| title_fullStr | Bioengineered probiotics to control SARS-CoV-2 infection |
| title_full_unstemmed | Bioengineered probiotics to control SARS-CoV-2 infection |
| title_short | Bioengineered probiotics to control SARS-CoV-2 infection |
| title_sort | bioengineered probiotics to control sars cov 2 infection |
| topic | SARS-CoV-2 ACE2 probiotics |
| url | https://riojournal.com/article/54802/download/pdf/ |
| work_keys_str_mv | AT shantibhusansenapati bioengineeredprobioticstocontrolsarscov2infection AT jayalaxmidash bioengineeredprobioticstocontrolsarscov2infection AT manishasethi bioengineeredprobioticstocontrolsarscov2infection AT subhankarchakraborty bioengineeredprobioticstocontrolsarscov2infection |