Transcriptome Analyses of β-Thalassemia −28(A>G) Mutation Using Isogenic Cell Models Generated by CRISPR/Cas9 and Asymmetric Single-Stranded Oligodeoxynucleotides (assODNs)

Transcriptome Analyses of β-Thalassemia −28(A>G) Mutation Using Isogenic Cell Models Generated by CRISPR/Cas9 and Asymmetric Single-Stranded Oligodeoxynucleotides (assODNs)

β-thalassemia, caused by mutations in the human hemoglobin β (HBB) gene, is one of the most common genetic diseases in the world. The HBB −28(A>G) mutation is one of the five most common mutations in Chinese patients with β-thalassemia. However, few studies have been conducted to understand h...

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Bibliographic Details
Main Authors: Jing Li, Ziheng Zhou, Hai-Xi Sun, Wenjie Ouyang, Guoyi Dong, Tianbin Liu, Lei Ge, Xiuqing Zhang, Chao Liu, Ying Gu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Genetics
Subjects:
β-thalassemia
HBB -28(A>G)
isogenic cells
K562
CRISPR/Cas9
assODNs
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2020.577053/full

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