Epigenetic activation of a subset of mRNAs by eIF4E explains its effects on cell proliferation.

Epigenetic activation of a subset of mRNAs by eIF4E explains its effects on cell proliferation.

BACKGROUND: Translation deregulation is an important mechanism that causes aberrant cell growth, proliferation and survival. eIF4E, the mRNA 5' cap-binding protein, plays a major role in translational control. To understand how eIF4E affects cell proliferation and survival, we studied mRNA targ...

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Bibliographic Details
Main Authors: Yaël Mamane, Emmanuel Petroulakis, Yvan Martineau, Taka-Aki Sato, Ola Larsson, Vinagolu K Rajasekhar, Nahum Sonenberg
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2007-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC1797416?pdf=render

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