Combination of anti-PD-1 therapy and stereotactic radiosurgery for a gastric cancer patient with brain metastasis: a case report
Abstract Background Brain metastases from gastric cancer are difficult to treat and their prognosis is poor. Despite various possible treatments, the survival rate of such patients is still unsatisfactory; therefore, new treatment modalities or combinations of therapies need to be explored. Case pre...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2018-02-01
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| Series: | BMC Cancer |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12885-017-3906-0 |
| _version_ | 1817999725242089472 |
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| author | Min-joo Ahn Kanghan Lee Kyung Hwa Lee Jin Woong Kim In-Young Kim Woo Kyun Bae |
| author_facet | Min-joo Ahn Kanghan Lee Kyung Hwa Lee Jin Woong Kim In-Young Kim Woo Kyun Bae |
| author_sort | Min-joo Ahn |
| collection | DOAJ |
| description | Abstract Background Brain metastases from gastric cancer are difficult to treat and their prognosis is poor. Despite various possible treatments, the survival rate of such patients is still unsatisfactory; therefore, new treatment modalities or combinations of therapies need to be explored. Case presentation We herein discuss a case of a 38-year-old man initially diagnosed with a gastric cancer brain metastasis. At first, only stereotactic radiosurgery (SRS) was performed, but it was not effective. After the brain and systemic metastases progressed, SRS and anti-PD-1 therapy were administered in combination, and the brain and intra-abdominal metastatic lesions responded satisfactorily. Conclusion The combination of anti-PD-1 therapy and SRS could be effective against gastric cancer with brain metastases. |
| first_indexed | 2024-04-14T03:12:53Z |
| format | Article |
| id | doaj.art-bc2ee6916c734576886d898ba713276e |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-04-14T03:12:53Z |
| publishDate | 2018-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj.art-bc2ee6916c734576886d898ba713276e2022-12-22T02:15:33ZengBMCBMC Cancer1471-24072018-02-011811410.1186/s12885-017-3906-0Combination of anti-PD-1 therapy and stereotactic radiosurgery for a gastric cancer patient with brain metastasis: a case reportMin-joo Ahn0Kanghan Lee1Kyung Hwa Lee2Jin Woong Kim3In-Young Kim4Woo Kyun Bae5Departments of Internal Medicine, Chonnam National University Medical SchoolDepartments of Internal Medicine, Chonnam National University Medical SchoolDepartments of Pathology, Chonnam National University Medical SchoolDepartments of Radiology, Chonnam National University Medical SchoolDepartments of Neurosurgery, Chonnam National University Medical SchoolDepartments of Internal Medicine, Chonnam National University Medical SchoolAbstract Background Brain metastases from gastric cancer are difficult to treat and their prognosis is poor. Despite various possible treatments, the survival rate of such patients is still unsatisfactory; therefore, new treatment modalities or combinations of therapies need to be explored. Case presentation We herein discuss a case of a 38-year-old man initially diagnosed with a gastric cancer brain metastasis. At first, only stereotactic radiosurgery (SRS) was performed, but it was not effective. After the brain and systemic metastases progressed, SRS and anti-PD-1 therapy were administered in combination, and the brain and intra-abdominal metastatic lesions responded satisfactorily. Conclusion The combination of anti-PD-1 therapy and SRS could be effective against gastric cancer with brain metastases.http://link.springer.com/article/10.1186/s12885-017-3906-0Anti-PD-1 therapyStereotactic radiosurgeryGastric cancerBrain metastasis |
| spellingShingle | Min-joo Ahn Kanghan Lee Kyung Hwa Lee Jin Woong Kim In-Young Kim Woo Kyun Bae Combination of anti-PD-1 therapy and stereotactic radiosurgery for a gastric cancer patient with brain metastasis: a case report BMC Cancer Anti-PD-1 therapy Stereotactic radiosurgery Gastric cancer Brain metastasis |
| title | Combination of anti-PD-1 therapy and stereotactic radiosurgery for a gastric cancer patient with brain metastasis: a case report |
| title_full | Combination of anti-PD-1 therapy and stereotactic radiosurgery for a gastric cancer patient with brain metastasis: a case report |
| title_fullStr | Combination of anti-PD-1 therapy and stereotactic radiosurgery for a gastric cancer patient with brain metastasis: a case report |
| title_full_unstemmed | Combination of anti-PD-1 therapy and stereotactic radiosurgery for a gastric cancer patient with brain metastasis: a case report |
| title_short | Combination of anti-PD-1 therapy and stereotactic radiosurgery for a gastric cancer patient with brain metastasis: a case report |
| title_sort | combination of anti pd 1 therapy and stereotactic radiosurgery for a gastric cancer patient with brain metastasis a case report |
| topic | Anti-PD-1 therapy Stereotactic radiosurgery Gastric cancer Brain metastasis |
| url | http://link.springer.com/article/10.1186/s12885-017-3906-0 |
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