Knockdown of glucose-regulated protein 78 decreases the invasion, metalloproteinase expression and ECM degradation in hepatocellular carcinoma cells

Knockdown of glucose-regulated protein 78 decreases the invasion, metalloproteinase expression and ECM degradation in hepatocellular carcinoma cells

<p>Abstract</p> <p>Background</p> <p>We have reported previously that overexpression of glucose-regulated protein 78 (GRP78) promotes the invasion of hepatocellular carcinoma. However, whether GRP78 knockdown affects the extracellular matrix degradation has not been elu...

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Bibliographic Details
Main Authors: Li Hongdan, Song Huijuan, Luo Junsheng, Liang Jia, Zhao Song, Su Rongjian
Format: Article
Language:English
Published: BMC 2012-04-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
GRP78
ECM degradation
MMP-2
JNK
Online Access:http://www.jeccr.com/content/31/1/39

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