Integrating scRNA and bulk-RNA sequencing develops a cell senescence signature for analyzing tumor heterogeneity in clear cell renal cell carcinoma

Integrating scRNA and bulk-RNA sequencing develops a cell senescence signature for analyzing tumor heterogeneity in clear cell renal cell carcinoma

IntroductionCellular senescence (CS) plays a critical role in cancer development, including clear cell renal cell carcinoma (ccRCC). Traditional RNA sequencing cannot detect precise molecular composition changes within tumors. This study aimed to analyze cellular senescence’s biochemical characteris...

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Bibliographic Details
Main Authors: Qiming Gong, Yan Jiang, Junfeng Xiong, Fahui Liu, Jikui Guan
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-07-01
Series:Frontiers in Immunology
Subjects:
ccRCC
senescence
single-cell
DUSP1
tumor heterogeneity
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1199002/full

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