Are Adenomyosis and Endometriosis Phenotypes of the Same Disease Process?
In recent literature reviews, we concluded that the possibility that endometrial molecular aberrations are the sole or a necessary determinant of endometriosis and the Tissue Injury and Repair (TIAR) theory are yet to be convincingly proven. Here, we critically examine the theory that adenomyosis an...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-12-01
|
| Series: | Biomolecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2218-273X/14/1/32 |
| _version_ | 1827372691261227008 |
|---|---|
| author | Marwan Habiba Sun-Wei Guo Giuseppe Benagiano |
| author_facet | Marwan Habiba Sun-Wei Guo Giuseppe Benagiano |
| author_sort | Marwan Habiba |
| collection | DOAJ |
| description | In recent literature reviews, we concluded that the possibility that endometrial molecular aberrations are the sole or a necessary determinant of endometriosis and the Tissue Injury and Repair (TIAR) theory are yet to be convincingly proven. Here, we critically examine the theory that adenomyosis and endometriosis represent different phenotypes of a single disease. A common etiopathology for adenomyosis and endometriosis has been suggested because both conditions entail the presence of endometrial tissue at locations other than the lining of the uterus. There are wide differences in reported disease incidence and prevalence and, consequently, in estimates of the coexistence of both conditions. There are some similarities but also differences in their clinical features and predisposing factors. Each condition has a range of subtypes. These differences alone pose the question of whether subtypes of endometriosis and adenomyosis have different etiopathologies, and, in turn, this raises the question of whether they all share a common etiology. It is debatable whether the recognized differences between the eutopic endometrium in adenomyosis and endometriosis compared to those in unaffected women are the cause or the effect of the disease. The finding of common mutations, particularly of <i>KRAS</i>, lend support to the notion of shared predisposing factors, but this alone is insufficient evidence of causation. |
| first_indexed | 2024-03-08T11:04:42Z |
| format | Article |
| id | doaj.art-bc390a5a757d41b38d8d9167f2380876 |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-08T11:04:42Z |
| publishDate | 2023-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-bc390a5a757d41b38d8d9167f23808762024-01-26T15:18:14ZengMDPI AGBiomolecules2218-273X2023-12-011413210.3390/biom14010032Are Adenomyosis and Endometriosis Phenotypes of the Same Disease Process?Marwan Habiba0Sun-Wei Guo1Giuseppe Benagiano2Department of Health Sciences, University of Leicester and University Hospitals of Leicester, Leicester LE1 5WW, UKDepartment of Biochemistry and Molecular Biology, Research Institute, Shanghai Obstetrics and Gynecology Hospital, Fudan University, Shanghai 200011, ChinaFaculty of Medicine and Surgery, Sapienza University of Rome, 00161 Rome, ItalyIn recent literature reviews, we concluded that the possibility that endometrial molecular aberrations are the sole or a necessary determinant of endometriosis and the Tissue Injury and Repair (TIAR) theory are yet to be convincingly proven. Here, we critically examine the theory that adenomyosis and endometriosis represent different phenotypes of a single disease. A common etiopathology for adenomyosis and endometriosis has been suggested because both conditions entail the presence of endometrial tissue at locations other than the lining of the uterus. There are wide differences in reported disease incidence and prevalence and, consequently, in estimates of the coexistence of both conditions. There are some similarities but also differences in their clinical features and predisposing factors. Each condition has a range of subtypes. These differences alone pose the question of whether subtypes of endometriosis and adenomyosis have different etiopathologies, and, in turn, this raises the question of whether they all share a common etiology. It is debatable whether the recognized differences between the eutopic endometrium in adenomyosis and endometriosis compared to those in unaffected women are the cause or the effect of the disease. The finding of common mutations, particularly of <i>KRAS</i>, lend support to the notion of shared predisposing factors, but this alone is insufficient evidence of causation.https://www.mdpi.com/2218-273X/14/1/32adenomyosisendometriosispathogenesisKRASepidemiology |
| spellingShingle | Marwan Habiba Sun-Wei Guo Giuseppe Benagiano Are Adenomyosis and Endometriosis Phenotypes of the Same Disease Process? Biomolecules adenomyosis endometriosis pathogenesis KRAS epidemiology |
| title | Are Adenomyosis and Endometriosis Phenotypes of the Same Disease Process? |
| title_full | Are Adenomyosis and Endometriosis Phenotypes of the Same Disease Process? |
| title_fullStr | Are Adenomyosis and Endometriosis Phenotypes of the Same Disease Process? |
| title_full_unstemmed | Are Adenomyosis and Endometriosis Phenotypes of the Same Disease Process? |
| title_short | Are Adenomyosis and Endometriosis Phenotypes of the Same Disease Process? |
| title_sort | are adenomyosis and endometriosis phenotypes of the same disease process |
| topic | adenomyosis endometriosis pathogenesis KRAS epidemiology |
| url | https://www.mdpi.com/2218-273X/14/1/32 |
| work_keys_str_mv | AT marwanhabiba areadenomyosisandendometriosisphenotypesofthesamediseaseprocess AT sunweiguo areadenomyosisandendometriosisphenotypesofthesamediseaseprocess AT giuseppebenagiano areadenomyosisandendometriosisphenotypesofthesamediseaseprocess |