Heterologous Immunization With Defined RNA and Subunit Vaccines Enhances T Cell Responses That Protect Against Leishmania donovani

Heterologous Immunization With Defined RNA and Subunit Vaccines Enhances T Cell Responses That Protect Against Leishmania donovani

The rapid generation of strong T cell responses is highly desirable and viral vectors can have potent CD8+ T cell-inducing activity. Immunity to leishmaniasis requires selective T cell responses, with immunization schemes that raise either CD4 or CD8 T cell responses being protective in small animal...

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Bibliographic Details
Main Authors: Malcolm S. Duthie, Neal Van Hoeven, Zachary MacMillen, Alessandro Picone, Raodoh Mohamath, Jesse Erasmus, Fan-Chi Hsu, Dan T. Stinchcomb, Steven G. Reed
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Immunology
Subjects:
leishmania
protein
vaccine
RNA
adjuvant
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02420/full

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