Recent advances in hidradenitis suppurativa: Role of race, genetics, and immunology
Hidradenitis suppurativa (HS) is a multifactorial chronic skin disease characterized by inflammation around the hair follicles commonly affecting intertriginous areas. The underlying pathogenesis of HS and its molecular mechanisms are largely understudied. Genetic studies in families have identified...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Genetics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fgene.2022.918858/full |
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| author | Gautham Vellaichamy Anya T. Amin Peter Dimitrion Peter Dimitrion Peter Dimitrion Zaakir Hamzavi Li Zhou Li Zhou Li Zhou Indra Adrianto Indra Adrianto Indra Adrianto Qing-Sheng Mi Qing-Sheng Mi Qing-Sheng Mi Qing-Sheng Mi |
| author_facet | Gautham Vellaichamy Anya T. Amin Peter Dimitrion Peter Dimitrion Peter Dimitrion Zaakir Hamzavi Li Zhou Li Zhou Li Zhou Indra Adrianto Indra Adrianto Indra Adrianto Qing-Sheng Mi Qing-Sheng Mi Qing-Sheng Mi Qing-Sheng Mi |
| author_sort | Gautham Vellaichamy |
| collection | DOAJ |
| description | Hidradenitis suppurativa (HS) is a multifactorial chronic skin disease characterized by inflammation around the hair follicles commonly affecting intertriginous areas. The underlying pathogenesis of HS and its molecular mechanisms are largely understudied. Genetic studies in families have identified variants within the γ-secretase complex associated with HS; however, no definitive genotype-phenotype correlations have been made. The lack of knowledge regarding the intersection of genetics, immunology and environmental risk factors is a major obstacle to improving treatment for patients with HS. This article provides an overview of the role of race, genetics, and immunology in HS to provide insight into the multiple factors influencing the pathophysiology of HS. |
| first_indexed | 2024-04-11T14:19:25Z |
| format | Article |
| id | doaj.art-bc39af0134a94d3a8daec8eee79db80e |
| institution | Directory Open Access Journal |
| issn | 1664-8021 |
| language | English |
| last_indexed | 2024-04-11T14:19:25Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Genetics |
| spelling | doaj.art-bc39af0134a94d3a8daec8eee79db80e2022-12-22T04:19:07ZengFrontiers Media S.A.Frontiers in Genetics1664-80212022-08-011310.3389/fgene.2022.918858918858Recent advances in hidradenitis suppurativa: Role of race, genetics, and immunologyGautham Vellaichamy0Anya T. Amin1Peter Dimitrion2Peter Dimitrion3Peter Dimitrion4Zaakir Hamzavi5Li Zhou6Li Zhou7Li Zhou8Indra Adrianto9Indra Adrianto10Indra Adrianto11Qing-Sheng Mi12Qing-Sheng Mi13Qing-Sheng Mi14Qing-Sheng Mi15Center for Cutaneous Biology and Immunology Research, Department of Dermatology, Henry Ford Health, Detroit, MI, United StatesCollege of Medicine and Life Sciences, University of Toledo, Toledo, OH, United StatesCenter for Cutaneous Biology and Immunology Research, Department of Dermatology, Henry Ford Health, Detroit, MI, United StatesImmunology Research Program, Henry Ford Cancer Institute, Henry Ford Health, Detroit, MI, United StatesCancer Biology Graduate Program, School of Medicine, Wayne State University, Detroit, MI, United StatesCenter for Cutaneous Biology and Immunology Research, Department of Dermatology, Henry Ford Health, Detroit, MI, United StatesCenter for Cutaneous Biology and Immunology Research, Department of Dermatology, Henry Ford Health, Detroit, MI, United StatesImmunology Research Program, Henry Ford Cancer Institute, Henry Ford Health, Detroit, MI, United StatesDepartment of Internal Medicine, Henry Ford Health, Detroit, MI, United StatesCenter for Cutaneous Biology and Immunology Research, Department of Dermatology, Henry Ford Health, Detroit, MI, United StatesImmunology Research Program, Henry Ford Cancer Institute, Henry Ford Health, Detroit, MI, United StatesCenter for Bioinformatics, Department of Public Health Sciences, Henry Ford Health, Detroit, MI, United StatesCenter for Cutaneous Biology and Immunology Research, Department of Dermatology, Henry Ford Health, Detroit, MI, United StatesImmunology Research Program, Henry Ford Cancer Institute, Henry Ford Health, Detroit, MI, United StatesCancer Biology Graduate Program, School of Medicine, Wayne State University, Detroit, MI, United StatesDepartment of Internal Medicine, Henry Ford Health, Detroit, MI, United StatesHidradenitis suppurativa (HS) is a multifactorial chronic skin disease characterized by inflammation around the hair follicles commonly affecting intertriginous areas. The underlying pathogenesis of HS and its molecular mechanisms are largely understudied. Genetic studies in families have identified variants within the γ-secretase complex associated with HS; however, no definitive genotype-phenotype correlations have been made. The lack of knowledge regarding the intersection of genetics, immunology and environmental risk factors is a major obstacle to improving treatment for patients with HS. This article provides an overview of the role of race, genetics, and immunology in HS to provide insight into the multiple factors influencing the pathophysiology of HS.https://www.frontiersin.org/articles/10.3389/fgene.2022.918858/fullhidradenitis suppurativageneticsimmunologyancestrygamma-secretase complextranscriptomics |
| spellingShingle | Gautham Vellaichamy Anya T. Amin Peter Dimitrion Peter Dimitrion Peter Dimitrion Zaakir Hamzavi Li Zhou Li Zhou Li Zhou Indra Adrianto Indra Adrianto Indra Adrianto Qing-Sheng Mi Qing-Sheng Mi Qing-Sheng Mi Qing-Sheng Mi Recent advances in hidradenitis suppurativa: Role of race, genetics, and immunology Frontiers in Genetics hidradenitis suppurativa genetics immunology ancestry gamma-secretase complex transcriptomics |
| title | Recent advances in hidradenitis suppurativa: Role of race, genetics, and immunology |
| title_full | Recent advances in hidradenitis suppurativa: Role of race, genetics, and immunology |
| title_fullStr | Recent advances in hidradenitis suppurativa: Role of race, genetics, and immunology |
| title_full_unstemmed | Recent advances in hidradenitis suppurativa: Role of race, genetics, and immunology |
| title_short | Recent advances in hidradenitis suppurativa: Role of race, genetics, and immunology |
| title_sort | recent advances in hidradenitis suppurativa role of race genetics and immunology |
| topic | hidradenitis suppurativa genetics immunology ancestry gamma-secretase complex transcriptomics |
| url | https://www.frontiersin.org/articles/10.3389/fgene.2022.918858/full |
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