Role of POC INR in the early stage of diagnosis of coagulopathy
Background: Acute bleeding requires fast and targeted therapy. Therefore, knowledge of the patient's potential to form a clot is crucial. Point-of-care testing (POCT) provides fast and reliable information on coagulation. Structural circumstances, such as person-bound sample transport, can prol...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2021-08-01
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| Series: | Practical Laboratory Medicine |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S235255172100038X |
| _version_ | 1823934750431117312 |
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| author | Florian J. Raimann Marie-Louise Lindner Christoph Martin Lukas Jennewein Thomas Lustenberger Florian Piekarski Kai Zacharowski Christian F. Weber |
| author_facet | Florian J. Raimann Marie-Louise Lindner Christoph Martin Lukas Jennewein Thomas Lustenberger Florian Piekarski Kai Zacharowski Christian F. Weber |
| author_sort | Florian J. Raimann |
| collection | DOAJ |
| description | Background: Acute bleeding requires fast and targeted therapy. Therefore, knowledge of the patient's potential to form a clot is crucial. Point-of-care testing (POCT) provides fast and reliable information on coagulation. Structural circumstances, such as person-bound sample transport, can prolong the reporting of the results. The aim of the present study was to investigate the diagnostic quality and accuracy between POCT INR diagnostics and standard laboratory analysis (SLA) as well as the time advantage between a pneumatic tube and a personal-based transport system. Methods: Two groups of haemorrhagic patients (EG: emergency department; OG: delivery room; each n = 12) were examined in the context of bleeding emergencies using POCT and SLA. Samples were transported via a pneumatic tube system or by a personal transport service. Results: INR results between POCT and SLA showed a high and significant correlation (EG: p < 0.001; OG: p < 0.001). POCT results were reported significantly more quickly (EG: 1.1 vs. 39.6 min; OG: 2.0 vs. 75.0 min; p < 0.001) and required less time for analysis (EG: 0.3 vs. 24.0 min; OG: 0.5 vs. 45.0 min; p < 0.001) compared to SLA. The time for transportation with the pneumatic tube was significantly shorter (8.0 vs. 18.5 min; p < 0.001) than with the personal-based transport system. Conclusion: The results of the present study suggest that POCT may be a suitable method for the emergency diagnosis and may be used as prognostic diagnostic elements in haemotherapy algorithms to initiate targeted haemotherapy at an early point in time. |
| first_indexed | 2024-12-16T22:24:53Z |
| format | Article |
| id | doaj.art-bc3a21fc513349dbba40317cacb16cd0 |
| institution | Directory Open Access Journal |
| issn | 2352-5517 |
| language | English |
| last_indexed | 2024-12-16T22:24:53Z |
| publishDate | 2021-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Practical Laboratory Medicine |
| spelling | doaj.art-bc3a21fc513349dbba40317cacb16cd02022-12-21T22:13:55ZengElsevierPractical Laboratory Medicine2352-55172021-08-0126e00238Role of POC INR in the early stage of diagnosis of coagulopathyFlorian J. Raimann0Marie-Louise Lindner1Christoph Martin2Lukas Jennewein3Thomas Lustenberger4Florian Piekarski5Kai Zacharowski6Christian F. Weber7Department of Anaesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Frankfurt, Goethe University Frankfurt, Germany; Corresponding author. Department of Anaesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Frankfurt, Theodor-Stern Kai 7, 60590, Frankfurt, Germany.Department of Anaesthesiology, Intensive Care Medicine and Emergency Medicine, Asklepios Clinics Hamburg, AK Wandsbek, Alphonsstraße 14, 22043, Hamburg, GermanyDepartment of Anaesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Frankfurt, Goethe University Frankfurt, GermanyDepartment of Gynecology and Obstetrics, University Hospital Frankfurt, Goethe University Frankfurt, GermanyDepartment of Trauma, Hand and Reconstructive Surgery, University Hospital Frankfurt, Goethe University Frankfurt, GermanyDepartment of Anaesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Frankfurt, Goethe University Frankfurt, GermanyDepartment of Anaesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Frankfurt, Goethe University Frankfurt, GermanyDepartment of Anaesthesiology, Intensive Care Medicine and Emergency Medicine, Asklepios Clinics Hamburg, AK Wandsbek, Alphonsstraße 14, 22043, Hamburg, GermanyBackground: Acute bleeding requires fast and targeted therapy. Therefore, knowledge of the patient's potential to form a clot is crucial. Point-of-care testing (POCT) provides fast and reliable information on coagulation. Structural circumstances, such as person-bound sample transport, can prolong the reporting of the results. The aim of the present study was to investigate the diagnostic quality and accuracy between POCT INR diagnostics and standard laboratory analysis (SLA) as well as the time advantage between a pneumatic tube and a personal-based transport system. Methods: Two groups of haemorrhagic patients (EG: emergency department; OG: delivery room; each n = 12) were examined in the context of bleeding emergencies using POCT and SLA. Samples were transported via a pneumatic tube system or by a personal transport service. Results: INR results between POCT and SLA showed a high and significant correlation (EG: p < 0.001; OG: p < 0.001). POCT results were reported significantly more quickly (EG: 1.1 vs. 39.6 min; OG: 2.0 vs. 75.0 min; p < 0.001) and required less time for analysis (EG: 0.3 vs. 24.0 min; OG: 0.5 vs. 45.0 min; p < 0.001) compared to SLA. The time for transportation with the pneumatic tube was significantly shorter (8.0 vs. 18.5 min; p < 0.001) than with the personal-based transport system. Conclusion: The results of the present study suggest that POCT may be a suitable method for the emergency diagnosis and may be used as prognostic diagnostic elements in haemotherapy algorithms to initiate targeted haemotherapy at an early point in time.http://www.sciencedirect.com/science/article/pii/S235255172100038XPoint-of-care testingInternational normalized ratioINRBleeding |
| spellingShingle | Florian J. Raimann Marie-Louise Lindner Christoph Martin Lukas Jennewein Thomas Lustenberger Florian Piekarski Kai Zacharowski Christian F. Weber Role of POC INR in the early stage of diagnosis of coagulopathy Practical Laboratory Medicine Point-of-care testing International normalized ratio INR Bleeding |
| title | Role of POC INR in the early stage of diagnosis of coagulopathy |
| title_full | Role of POC INR in the early stage of diagnosis of coagulopathy |
| title_fullStr | Role of POC INR in the early stage of diagnosis of coagulopathy |
| title_full_unstemmed | Role of POC INR in the early stage of diagnosis of coagulopathy |
| title_short | Role of POC INR in the early stage of diagnosis of coagulopathy |
| title_sort | role of poc inr in the early stage of diagnosis of coagulopathy |
| topic | Point-of-care testing International normalized ratio INR Bleeding |
| url | http://www.sciencedirect.com/science/article/pii/S235255172100038X |
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