The autophagy protein ATG9A enables lipid mobilization from lipid droplets
ATG9A is transmembrane autophagic machinery protein that delivers phospholipids to expanding autophagosomes. Mailler et al. show that ATG9A is required to mobilize lipids from lipid droplets for autophagosome expansion as well as mitochondrial fatty acid import and β-oxidation.
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-11-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-26999-x |
| _version_ | 1818913207126851584 |
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| author | Elodie Mailler Carlos M. Guardia Xiaofei Bai Michal Jarnik Chad D. Williamson Yan Li Nunziata Maio Andy Golden Juan S. Bonifacino |
| author_facet | Elodie Mailler Carlos M. Guardia Xiaofei Bai Michal Jarnik Chad D. Williamson Yan Li Nunziata Maio Andy Golden Juan S. Bonifacino |
| author_sort | Elodie Mailler |
| collection | DOAJ |
| description | ATG9A is transmembrane autophagic machinery protein that delivers phospholipids to expanding autophagosomes. Mailler et al. show that ATG9A is required to mobilize lipids from lipid droplets for autophagosome expansion as well as mitochondrial fatty acid import and β-oxidation. |
| first_indexed | 2024-12-19T23:26:49Z |
| format | Article |
| id | doaj.art-bc3b482686c54ef6a34fb727e681922d |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-19T23:26:49Z |
| publishDate | 2021-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-bc3b482686c54ef6a34fb727e681922d2022-12-21T20:01:50ZengNature PortfolioNature Communications2041-17232021-11-0112111910.1038/s41467-021-26999-xThe autophagy protein ATG9A enables lipid mobilization from lipid dropletsElodie Mailler0Carlos M. Guardia1Xiaofei Bai2Michal Jarnik3Chad D. Williamson4Yan Li5Nunziata Maio6Andy Golden7Juan S. Bonifacino8Neurosciences and Cellular and Structural Biology Division, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of HealthNeurosciences and Cellular and Structural Biology Division, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of HealthLaboratory of Biochemistry and Genetics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of HealthNeurosciences and Cellular and Structural Biology Division, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of HealthNeurosciences and Cellular and Structural Biology Division, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of HealthProteomics Core Facility, National Institute of Neurological Disorders and Stroke, National Institutes of HealthMetals Biology and Molecular Medicine Group, Eunice Kennedy Shriver National Institute of Child Health and Human DevelopmentLaboratory of Biochemistry and Genetics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of HealthNeurosciences and Cellular and Structural Biology Division, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of HealthATG9A is transmembrane autophagic machinery protein that delivers phospholipids to expanding autophagosomes. Mailler et al. show that ATG9A is required to mobilize lipids from lipid droplets for autophagosome expansion as well as mitochondrial fatty acid import and β-oxidation.https://doi.org/10.1038/s41467-021-26999-x |
| spellingShingle | Elodie Mailler Carlos M. Guardia Xiaofei Bai Michal Jarnik Chad D. Williamson Yan Li Nunziata Maio Andy Golden Juan S. Bonifacino The autophagy protein ATG9A enables lipid mobilization from lipid droplets Nature Communications |
| title | The autophagy protein ATG9A enables lipid mobilization from lipid droplets |
| title_full | The autophagy protein ATG9A enables lipid mobilization from lipid droplets |
| title_fullStr | The autophagy protein ATG9A enables lipid mobilization from lipid droplets |
| title_full_unstemmed | The autophagy protein ATG9A enables lipid mobilization from lipid droplets |
| title_short | The autophagy protein ATG9A enables lipid mobilization from lipid droplets |
| title_sort | autophagy protein atg9a enables lipid mobilization from lipid droplets |
| url | https://doi.org/10.1038/s41467-021-26999-x |
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