Target repression induced by endogenous microRNAs: large differences, small effects.

MicroRNAs are small RNAs that regulate protein levels. It is commonly assumed that the expression level of a microRNA is directly correlated with its repressive activity - that is, highly expressed microRNAs will repress their target mRNAs more. Here we investigate the quantitative relationship betw...

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Bibliographic Details
Main Authors: Ana Kozomara, Suzanne Hunt, Maria Ninova, Sam Griffiths-Jones, Matthew Ronshaugen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4139194?pdf=render