Polymorphic variants of IL2 and IL4 genes as markers of infertility in case of genital endometriosis
92 patients with genital endometriosis and diagnosed infertility were clinically examined and went through molecular-genetical testing and therapy. Complex therapy included laparoscopic surgery and the course of hormonal therapy (gonadotrophin releasing hormone agonists, combined oral contraceptives...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Peoples’ Friendship University of Russia (RUDN University)
2012-12-01
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| Series: | RUDN Journal of Medicine |
| Subjects: | |
| Online Access: | http://journals.rudn.ru/medicine/article/view/3678 |
| _version_ | 1828233904792797184 |
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| author | K S Kublinsky I D Evtushenko I O Naslednikova T A Agarkova |
| author_facet | K S Kublinsky I D Evtushenko I O Naslednikova T A Agarkova |
| author_sort | K S Kublinsky |
| collection | DOAJ |
| description | 92 patients with genital endometriosis and diagnosed infertility were clinically examined and went through molecular-genetical testing and therapy. Complex therapy included laparoscopic surgery and the course of hormonal therapy (gonadotrophin releasing hormone agonists, combined oral contraceptives). The effect of the therapy increases as increases the possibility of pregnancy in the presence of IL2 gene T-330G TT polymorphism variant and IL4 gene C-590T CC polymorphism variant in the genotype of a woman. The decreased effect of infertility treatment with the diagnosed endometriosis is associated with the presence of the hazardous genotype combination: IL2 gene T-330G GG polymorphism and IL4 gene C-590T TT polymorphism. |
| first_indexed | 2024-04-12T19:46:51Z |
| format | Article |
| id | doaj.art-bc42ed59018a4e5ea86b937f70bee4ed |
| institution | Directory Open Access Journal |
| issn | 2313-0245 2313-0261 |
| language | English |
| last_indexed | 2024-04-12T19:46:51Z |
| publishDate | 2012-12-01 |
| publisher | Peoples’ Friendship University of Russia (RUDN University) |
| record_format | Article |
| series | RUDN Journal of Medicine |
| spelling | doaj.art-bc42ed59018a4e5ea86b937f70bee4ed2022-12-22T03:18:56ZengPeoples’ Friendship University of Russia (RUDN University)RUDN Journal of Medicine2313-02452313-02612012-12-010S61021093678Polymorphic variants of IL2 and IL4 genes as markers of infertility in case of genital endometriosisK S Kublinsky0I D Evtushenko1I O Naslednikova2T A Agarkova3Сибирский государственный медицинский университетСибирский государственный медицинский университетСибирский государственный медицинский университетНаучно-исследовательский институт акушерства, гинекологии и перинатологии92 patients with genital endometriosis and diagnosed infertility were clinically examined and went through molecular-genetical testing and therapy. Complex therapy included laparoscopic surgery and the course of hormonal therapy (gonadotrophin releasing hormone agonists, combined oral contraceptives). The effect of the therapy increases as increases the possibility of pregnancy in the presence of IL2 gene T-330G TT polymorphism variant and IL4 gene C-590T CC polymorphism variant in the genotype of a woman. The decreased effect of infertility treatment with the diagnosed endometriosis is associated with the presence of the hazardous genotype combination: IL2 gene T-330G GG polymorphism and IL4 gene C-590T TT polymorphism.http://journals.rudn.ru/medicine/article/view/3678эндометриозбесплодиеинтерлейкин-2интерлейкин-4полиморфизм генов цитокинов |
| spellingShingle | K S Kublinsky I D Evtushenko I O Naslednikova T A Agarkova Polymorphic variants of IL2 and IL4 genes as markers of infertility in case of genital endometriosis RUDN Journal of Medicine эндометриоз бесплодие интерлейкин-2 интерлейкин-4 полиморфизм генов цитокинов |
| title | Polymorphic variants of IL2 and IL4 genes as markers of infertility in case of genital endometriosis |
| title_full | Polymorphic variants of IL2 and IL4 genes as markers of infertility in case of genital endometriosis |
| title_fullStr | Polymorphic variants of IL2 and IL4 genes as markers of infertility in case of genital endometriosis |
| title_full_unstemmed | Polymorphic variants of IL2 and IL4 genes as markers of infertility in case of genital endometriosis |
| title_short | Polymorphic variants of IL2 and IL4 genes as markers of infertility in case of genital endometriosis |
| title_sort | polymorphic variants of il2 and il4 genes as markers of infertility in case of genital endometriosis |
| topic | эндометриоз бесплодие интерлейкин-2 интерлейкин-4 полиморфизм генов цитокинов |
| url | http://journals.rudn.ru/medicine/article/view/3678 |
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