Clinical Characteristics and Prognostic Analysis of Gynecologic Cancer with Spinal Metastases: A Single-Center Retrospective Study
Shuzhong Liu,1,* Xi Zhou,1,* An Song,2 Zhen Huo,3 Siyuan Yao,1 Yipeng Wang,1 Yong Liu,1,* Ling-Ya Pan4,* 1Department of Orthopaedic Surgery, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, People’s Republic of China; 2De...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2020-08-01
|
| Series: | Cancer Management and Research |
| Subjects: | |
| Online Access: | https://www.dovepress.com/clinical-characteristics-and-prognostic-analysis-of-gynecologic-cancer-peer-reviewed-article-CMAR |
| _version_ | 1819209626844921856 |
|---|---|
| author | Liu S Zhou X Song A Huo Z Yao S Wang Y Liu Y Pan LY |
| author_facet | Liu S Zhou X Song A Huo Z Yao S Wang Y Liu Y Pan LY |
| author_sort | Liu S |
| collection | DOAJ |
| description | Shuzhong Liu,1,* Xi Zhou,1,* An Song,2 Zhen Huo,3 Siyuan Yao,1 Yipeng Wang,1 Yong Liu,1,* Ling-Ya Pan4,* 1Department of Orthopaedic Surgery, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, People’s Republic of China; 2Department of Endocrinology, Key Laboratory of Endocrinology, National Health and Family Planning Commission, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, People’s Republic of China; 3Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, People’s Republic of China; 4Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yong LiuDepartment of Orthopaedic Surgery, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, No. 1 Shuaifuyuan Wangfujing, Beijing 100730, People’s Republic of China, Email liuyong_pumch@163.comLing-Ya PanDepartment of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, People’s Republic of ChinaEmail panly@pumch.cnObjective: The purpose of this study is to provide key information on the clinical characteristics, surgical treatment, and potential prognostic factors in patients with metastatic spinal gynecologic cancer (MSGC), with a view to their application in clinical practice.Methods: From January 2010 to January 2020, we performed a retrospective analysis of 14 patients with MSGC who underwent surgical treatment in a single center. Surgical treatment was performed on 14 patients, and a total of 14 operations were performed. The survival time of patients after spinal surgery was analyzed by Kaplan–Meier and Cox regression analysis.Results: The average age of patients was 51.9 years (range 25‒70). The average time from initial surgery to the discovery of spinal metastasis was 60.3 months (2‒180), and the average follow-up time was 19.2 months (2‒55). Spinal tumor progression was found in 9 patients, and 12 patients (85.7%) died during follow-up. In univariate analysis, extraosseous visceral metastasis (p = 0.024), revised Tokuhashi stage (p = 0.025), Tomita stage (p = 0.005), and number of spinal lesions (p = 0.038) were associated with overall survival (OS). Extraosseous visceral metastasis (p = 0.026), revised Tokuhashi stage (p = 0.014), Tomita stage (p = 0.001), and gynecological cancer type (p = 0.039) were associated with progression-free survival.Conclusion: Surgical treatment is an effective treatment for MSGC and relieves pain, restores function and rebuilds stability. Based on our single-center experience, extraosseous visceral metastasis, revised Tokuhashi stage, Tomita stage, and gynecological cancer type may be potential prognostic factors for OS.Keywords: clinical prognosis, gynecological cancer, overall survival, progression-free survival, spinal metastasis, surgical treatment |
| first_indexed | 2024-12-23T05:58:17Z |
| format | Article |
| id | doaj.art-bc433bc19c83480bb43f51949d427a93 |
| institution | Directory Open Access Journal |
| issn | 1179-1322 |
| language | English |
| last_indexed | 2024-12-23T05:58:17Z |
| publishDate | 2020-08-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Cancer Management and Research |
| spelling | doaj.art-bc433bc19c83480bb43f51949d427a932022-12-21T17:57:45ZengDove Medical PressCancer Management and Research1179-13222020-08-01Volume 127515752556388Clinical Characteristics and Prognostic Analysis of Gynecologic Cancer with Spinal Metastases: A Single-Center Retrospective StudyLiu SZhou XSong AHuo ZYao SWang YLiu YPan LYShuzhong Liu,1,* Xi Zhou,1,* An Song,2 Zhen Huo,3 Siyuan Yao,1 Yipeng Wang,1 Yong Liu,1,* Ling-Ya Pan4,* 1Department of Orthopaedic Surgery, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, People’s Republic of China; 2Department of Endocrinology, Key Laboratory of Endocrinology, National Health and Family Planning Commission, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, People’s Republic of China; 3Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, People’s Republic of China; 4Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yong LiuDepartment of Orthopaedic Surgery, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, No. 1 Shuaifuyuan Wangfujing, Beijing 100730, People’s Republic of China, Email liuyong_pumch@163.comLing-Ya PanDepartment of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, People’s Republic of ChinaEmail panly@pumch.cnObjective: The purpose of this study is to provide key information on the clinical characteristics, surgical treatment, and potential prognostic factors in patients with metastatic spinal gynecologic cancer (MSGC), with a view to their application in clinical practice.Methods: From January 2010 to January 2020, we performed a retrospective analysis of 14 patients with MSGC who underwent surgical treatment in a single center. Surgical treatment was performed on 14 patients, and a total of 14 operations were performed. The survival time of patients after spinal surgery was analyzed by Kaplan–Meier and Cox regression analysis.Results: The average age of patients was 51.9 years (range 25‒70). The average time from initial surgery to the discovery of spinal metastasis was 60.3 months (2‒180), and the average follow-up time was 19.2 months (2‒55). Spinal tumor progression was found in 9 patients, and 12 patients (85.7%) died during follow-up. In univariate analysis, extraosseous visceral metastasis (p = 0.024), revised Tokuhashi stage (p = 0.025), Tomita stage (p = 0.005), and number of spinal lesions (p = 0.038) were associated with overall survival (OS). Extraosseous visceral metastasis (p = 0.026), revised Tokuhashi stage (p = 0.014), Tomita stage (p = 0.001), and gynecological cancer type (p = 0.039) were associated with progression-free survival.Conclusion: Surgical treatment is an effective treatment for MSGC and relieves pain, restores function and rebuilds stability. Based on our single-center experience, extraosseous visceral metastasis, revised Tokuhashi stage, Tomita stage, and gynecological cancer type may be potential prognostic factors for OS.Keywords: clinical prognosis, gynecological cancer, overall survival, progression-free survival, spinal metastasis, surgical treatmenthttps://www.dovepress.com/clinical-characteristics-and-prognostic-analysis-of-gynecologic-cancer-peer-reviewed-article-CMARclinical prognosisgynecological canceroverall survivalprogression-free survivalspinal metastasissurgical treatment |
| spellingShingle | Liu S Zhou X Song A Huo Z Yao S Wang Y Liu Y Pan LY Clinical Characteristics and Prognostic Analysis of Gynecologic Cancer with Spinal Metastases: A Single-Center Retrospective Study Cancer Management and Research clinical prognosis gynecological cancer overall survival progression-free survival spinal metastasis surgical treatment |
| title | Clinical Characteristics and Prognostic Analysis of Gynecologic Cancer with Spinal Metastases: A Single-Center Retrospective Study |
| title_full | Clinical Characteristics and Prognostic Analysis of Gynecologic Cancer with Spinal Metastases: A Single-Center Retrospective Study |
| title_fullStr | Clinical Characteristics and Prognostic Analysis of Gynecologic Cancer with Spinal Metastases: A Single-Center Retrospective Study |
| title_full_unstemmed | Clinical Characteristics and Prognostic Analysis of Gynecologic Cancer with Spinal Metastases: A Single-Center Retrospective Study |
| title_short | Clinical Characteristics and Prognostic Analysis of Gynecologic Cancer with Spinal Metastases: A Single-Center Retrospective Study |
| title_sort | clinical characteristics and prognostic analysis of gynecologic cancer with spinal metastases a single center retrospective study |
| topic | clinical prognosis gynecological cancer overall survival progression-free survival spinal metastasis surgical treatment |
| url | https://www.dovepress.com/clinical-characteristics-and-prognostic-analysis-of-gynecologic-cancer-peer-reviewed-article-CMAR |
| work_keys_str_mv | AT lius clinicalcharacteristicsandprognosticanalysisofgynecologiccancerwithspinalmetastasesasinglecenterretrospectivestudy AT zhoux clinicalcharacteristicsandprognosticanalysisofgynecologiccancerwithspinalmetastasesasinglecenterretrospectivestudy AT songa clinicalcharacteristicsandprognosticanalysisofgynecologiccancerwithspinalmetastasesasinglecenterretrospectivestudy AT huoz clinicalcharacteristicsandprognosticanalysisofgynecologiccancerwithspinalmetastasesasinglecenterretrospectivestudy AT yaos clinicalcharacteristicsandprognosticanalysisofgynecologiccancerwithspinalmetastasesasinglecenterretrospectivestudy AT wangy clinicalcharacteristicsandprognosticanalysisofgynecologiccancerwithspinalmetastasesasinglecenterretrospectivestudy AT liuy clinicalcharacteristicsandprognosticanalysisofgynecologiccancerwithspinalmetastasesasinglecenterretrospectivestudy AT panly clinicalcharacteristicsandprognosticanalysisofgynecologiccancerwithspinalmetastasesasinglecenterretrospectivestudy |