La Relationship between vitamin B12 levels and insulin resistance in postmenopausal women from Colombia Caribbean
Introduction: The high prevalence of low vitamin B12 serum levels has been recognized as a public health problem in Latin America; however, the current magnitude of this deficiency in Colombia is uncertain. Low levels of vitamin B12 can induce clinical and subclinical hematological and neurological...
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| Format: | Article |
| Language: | Portuguese |
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Universidade de São Paulo
2023-04-01
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| Series: | Medicina |
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| Online Access: | https://www.revistas.usp.br/rmrp/article/view/201354 |
| _version_ | 1797846572971589632 |
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| author | Luz Adriana Sarmiento-Rubiano Jimmy Everth Becerra Roberto Carlos Rebolledo-Cobos Norella Ortega-Ariza María Cristina Sarmiento-Rubiano |
| author_facet | Luz Adriana Sarmiento-Rubiano Jimmy Everth Becerra Roberto Carlos Rebolledo-Cobos Norella Ortega-Ariza María Cristina Sarmiento-Rubiano |
| author_sort | Luz Adriana Sarmiento-Rubiano |
| collection | DOAJ |
| description |
Introduction: The high prevalence of low vitamin B12 serum levels has been recognized as a public health problem in Latin America; however, the current magnitude of this deficiency in Colombia is uncertain. Low levels of vitamin B12 can induce clinical and subclinical hematological and neurological disorders. Epidemiological studies have demonstrated a relationship between vitamin B12 deficiency and cardiovascular diseases (CVDs). However, the role of vitamin B12 in insulin resistance has been poorly studied. Objective: This study aimed to evaluate the relationship between vitamin B12 serum levels and biochemical and anthropometric markers related to CVDs and insulin resistance in postmenopausal women from Colombia Caribbean. Methods: Correlational, descriptive study. By convenience sampling, 182 postmenopausal women from the medical consultation service of a health institution were linked. Serum vitamin B12 levels, anthropometric variables (body mass index, abdominal perimeter), and biochemical variables (glycemia, insulin, lipid profile, HOMA IR) were evaluated. Results: The average value of the vitamin B12 serum level was 312.5 ± 122.5 pg/mL (230.6 ± 90.4 pmol/L); 46.7% of the women had less than adequate levels of 300 pg/mL (> 221 pmol/L), and 9. 9% were deficient, with levels of less than 200 pg/mL (148 pmol/L). The women with metabolic syndrome were 63.7%, and according to HOMA IR, 52.7 % had insulin resistance. A significant inverse relationship was shown between serum vitamin B12 levels with basal glycemic (P =0.002) and HOMA-IR (P =0.040). Conclusions: A significant inverse relationship between vitamin B12 levels and basal glycemia and HOMA-IR was observed. These findings highlight vitamin B12 deficiency in postmenopausal women and suggest nutritional supplementation.
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| first_indexed | 2024-04-09T17:57:11Z |
| format | Article |
| id | doaj.art-bc458d4d1c054209a545aefd1c9ef5c8 |
| institution | Directory Open Access Journal |
| issn | 0076-6046 2176-7262 |
| language | Portuguese |
| last_indexed | 2024-04-09T17:57:11Z |
| publishDate | 2023-04-01 |
| publisher | Universidade de São Paulo |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-bc458d4d1c054209a545aefd1c9ef5c82023-04-14T16:04:39ZporUniversidade de São PauloMedicina0076-60462176-72622023-04-01561La Relationship between vitamin B12 levels and insulin resistance in postmenopausal women from Colombia CaribbeanLuz Adriana Sarmiento-Rubiano0Jimmy Everth Becerra1Roberto Carlos Rebolledo-Cobos2Norella Ortega-Ariza3María Cristina Sarmiento-Rubiano4Metropolitana University. Group Food and Human Behavior, Barranquilla, Atlántico Colombia.Metropolitana University. Group Food and Human Behavior, Barranquilla, Atlántico Colombia.Metropolitan University. Critical care and functional rehabilitation Investigation Group, Barranquilla, Colombia.Metropolitan University, Research Department, Barranquilla, Colombia.Sinú University, Preventive and Community Medicine, Cartagena, Colombia Introduction: The high prevalence of low vitamin B12 serum levels has been recognized as a public health problem in Latin America; however, the current magnitude of this deficiency in Colombia is uncertain. Low levels of vitamin B12 can induce clinical and subclinical hematological and neurological disorders. Epidemiological studies have demonstrated a relationship between vitamin B12 deficiency and cardiovascular diseases (CVDs). However, the role of vitamin B12 in insulin resistance has been poorly studied. Objective: This study aimed to evaluate the relationship between vitamin B12 serum levels and biochemical and anthropometric markers related to CVDs and insulin resistance in postmenopausal women from Colombia Caribbean. Methods: Correlational, descriptive study. By convenience sampling, 182 postmenopausal women from the medical consultation service of a health institution were linked. Serum vitamin B12 levels, anthropometric variables (body mass index, abdominal perimeter), and biochemical variables (glycemia, insulin, lipid profile, HOMA IR) were evaluated. Results: The average value of the vitamin B12 serum level was 312.5 ± 122.5 pg/mL (230.6 ± 90.4 pmol/L); 46.7% of the women had less than adequate levels of 300 pg/mL (> 221 pmol/L), and 9. 9% were deficient, with levels of less than 200 pg/mL (148 pmol/L). The women with metabolic syndrome were 63.7%, and according to HOMA IR, 52.7 % had insulin resistance. A significant inverse relationship was shown between serum vitamin B12 levels with basal glycemic (P =0.002) and HOMA-IR (P =0.040). Conclusions: A significant inverse relationship between vitamin B12 levels and basal glycemia and HOMA-IR was observed. These findings highlight vitamin B12 deficiency in postmenopausal women and suggest nutritional supplementation. https://www.revistas.usp.br/rmrp/article/view/201354Vitamin B12Insulin resistanceDietPostmenopauseCardiovascular diseases |
| spellingShingle | Luz Adriana Sarmiento-Rubiano Jimmy Everth Becerra Roberto Carlos Rebolledo-Cobos Norella Ortega-Ariza María Cristina Sarmiento-Rubiano La Relationship between vitamin B12 levels and insulin resistance in postmenopausal women from Colombia Caribbean Medicina Vitamin B12 Insulin resistance Diet Postmenopause Cardiovascular diseases |
| title | La Relationship between vitamin B12 levels and insulin resistance in postmenopausal women from Colombia Caribbean |
| title_full | La Relationship between vitamin B12 levels and insulin resistance in postmenopausal women from Colombia Caribbean |
| title_fullStr | La Relationship between vitamin B12 levels and insulin resistance in postmenopausal women from Colombia Caribbean |
| title_full_unstemmed | La Relationship between vitamin B12 levels and insulin resistance in postmenopausal women from Colombia Caribbean |
| title_short | La Relationship between vitamin B12 levels and insulin resistance in postmenopausal women from Colombia Caribbean |
| title_sort | la relationship between vitamin b12 levels and insulin resistance in postmenopausal women from colombia caribbean |
| topic | Vitamin B12 Insulin resistance Diet Postmenopause Cardiovascular diseases |
| url | https://www.revistas.usp.br/rmrp/article/view/201354 |
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