Microcirculatory dysfunction in cardiogenic shock
Abstract Cardiogenic shock is usually defined as primary cardiac dysfunction with low cardiac output leading to critical organ hypoperfusion, and tissue hypoxia, resulting in high mortality rate between 40% and 50% despite recent advances. Many studies have now evidenced that cardiogenic shock not o...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2023-05-01
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| Series: | Annals of Intensive Care |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13613-023-01130-z |
| _version_ | 1797831906506571776 |
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| author | Hamid Merdji Bruno Levy Christian Jung Can Ince Martin Siegemund Ferhat Meziani |
| author_facet | Hamid Merdji Bruno Levy Christian Jung Can Ince Martin Siegemund Ferhat Meziani |
| author_sort | Hamid Merdji |
| collection | DOAJ |
| description | Abstract Cardiogenic shock is usually defined as primary cardiac dysfunction with low cardiac output leading to critical organ hypoperfusion, and tissue hypoxia, resulting in high mortality rate between 40% and 50% despite recent advances. Many studies have now evidenced that cardiogenic shock not only involves systemic macrocirculation, such as blood pressure, left ventricular ejection fraction, or cardiac output, but also involves significant systemic microcirculatory abnormalities which seem strongly associated with the outcome. Although microcirculation has been widely studied in the context of septic shock showing heterogeneous alterations with clear evidence of macro and microcirculation uncoupling, there is now a growing body of literature focusing on cardiogenic shock states. Even if there is currently no consensus regarding the treatment of microcirculatory disturbances in cardiogenic shock, some treatments seem to show a benefit. Furthermore, a better understanding of the underlying pathophysiology may provide hypotheses for future studies aiming to improve cardiogenic shock prognosis. Graphical Abstract |
| first_indexed | 2024-04-09T14:00:20Z |
| format | Article |
| id | doaj.art-bc4798bf1693487eb056edf6e3dfca2a |
| institution | Directory Open Access Journal |
| issn | 2110-5820 |
| language | English |
| last_indexed | 2024-04-09T14:00:20Z |
| publishDate | 2023-05-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Annals of Intensive Care |
| spelling | doaj.art-bc4798bf1693487eb056edf6e3dfca2a2023-05-07T11:23:35ZengSpringerOpenAnnals of Intensive Care2110-58202023-05-0113111510.1186/s13613-023-01130-zMicrocirculatory dysfunction in cardiogenic shockHamid Merdji0Bruno Levy1Christian Jung2Can Ince3Martin Siegemund4Ferhat Meziani5Intensive Care Unit, Department of Acute Medicine, University HospitalInstitut Lorrain du Cœur et des Vaisseaux, Medical Intensive Care Unit Brabois, Université de Lorraine, CHRU de Nancy, INSERM U1116Division of Cardiology, Pulmonology, and Vascular Medicine, Medical Faculty, University Hospital Düsseldorf, Heinrich-Heine-UniversityDepartment of Intensive Care, Erasmus MC, University Medical CenterIntensive Care Unit, Department of Acute Medicine, University HospitalFaculté de Médecine, Université de Strasbourg (UNISTRA)Abstract Cardiogenic shock is usually defined as primary cardiac dysfunction with low cardiac output leading to critical organ hypoperfusion, and tissue hypoxia, resulting in high mortality rate between 40% and 50% despite recent advances. Many studies have now evidenced that cardiogenic shock not only involves systemic macrocirculation, such as blood pressure, left ventricular ejection fraction, or cardiac output, but also involves significant systemic microcirculatory abnormalities which seem strongly associated with the outcome. Although microcirculation has been widely studied in the context of septic shock showing heterogeneous alterations with clear evidence of macro and microcirculation uncoupling, there is now a growing body of literature focusing on cardiogenic shock states. Even if there is currently no consensus regarding the treatment of microcirculatory disturbances in cardiogenic shock, some treatments seem to show a benefit. Furthermore, a better understanding of the underlying pathophysiology may provide hypotheses for future studies aiming to improve cardiogenic shock prognosis. Graphical Abstracthttps://doi.org/10.1186/s13613-023-01130-zCardiogenic shockHeart failureMicrocirculationMacrocirculationPerfusion parameters |
| spellingShingle | Hamid Merdji Bruno Levy Christian Jung Can Ince Martin Siegemund Ferhat Meziani Microcirculatory dysfunction in cardiogenic shock Annals of Intensive Care Cardiogenic shock Heart failure Microcirculation Macrocirculation Perfusion parameters |
| title | Microcirculatory dysfunction in cardiogenic shock |
| title_full | Microcirculatory dysfunction in cardiogenic shock |
| title_fullStr | Microcirculatory dysfunction in cardiogenic shock |
| title_full_unstemmed | Microcirculatory dysfunction in cardiogenic shock |
| title_short | Microcirculatory dysfunction in cardiogenic shock |
| title_sort | microcirculatory dysfunction in cardiogenic shock |
| topic | Cardiogenic shock Heart failure Microcirculation Macrocirculation Perfusion parameters |
| url | https://doi.org/10.1186/s13613-023-01130-z |
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