Endothelial Function in Patients With Von Willebrand Disease
In patients with von Willebrand disease (vWD) the interest in age-related comorbidities has grown, because the life expectancy of these patients has increased. The research question of this study was whether patients with vWD show a different endothelial function compared to the general population....
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2021-01-01
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| Series: | Clinical and Applied Thrombosis/Hemostasis |
| Online Access: | https://doi.org/10.1177/1076029620984546 |
| _version_ | 1818428260765138944 |
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| author | Stephanie Noone MD Ralf Schubert MSc, PhD Stephan Fichtlscherer MD, PhD Thomas Hilberg MD, PhD Sonja Alesci MD Wolfgang Miesbach MD, PhD |
| author_facet | Stephanie Noone MD Ralf Schubert MSc, PhD Stephan Fichtlscherer MD, PhD Thomas Hilberg MD, PhD Sonja Alesci MD Wolfgang Miesbach MD, PhD |
| author_sort | Stephanie Noone MD |
| collection | DOAJ |
| description | In patients with von Willebrand disease (vWD) the interest in age-related comorbidities has grown, because the life expectancy of these patients has increased. The research question of this study was whether patients with vWD show a different endothelial function compared to the general population. A total of 37 patients with type 1 (n = 23), type 2 (n = 10) and type 3 (n = 4) vWD, 14 controls and 38 patients with coronary artery disease (CAD) were included in this study. Five markers of endothelial dysfunction (MOED) were determined. Moreover, the endothelial function was examined using the Itamar Endo-PAT. The reactive hyperemia index (RHI) was calculated from the results. The markers soluble intercellular adhesion molecule-1 (p = 0.171), P-Selectin (p = 0.512), interleukin-6 (p = 0.734) and monocyte chemoattractant protein-1 (p = 0.761) showed higher levels in patients with vWD, but were not significantly different compared to the control group. RHI was impaired in CAD-patients (1.855), whereas vWD patients had mean results of 1.870 and controls 2.112 (p = 0.367). In this study, the endothelial function measurements of patients with von Willebrand disease were not significantly different compared to healthy controls. |
| first_indexed | 2024-12-14T14:58:48Z |
| format | Article |
| id | doaj.art-bc48ad3b41f0405eb817cd34902de117 |
| institution | Directory Open Access Journal |
| issn | 1938-2723 |
| language | English |
| last_indexed | 2024-12-14T14:58:48Z |
| publishDate | 2021-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Clinical and Applied Thrombosis/Hemostasis |
| spelling | doaj.art-bc48ad3b41f0405eb817cd34902de1172022-12-21T22:56:54ZengSAGE PublishingClinical and Applied Thrombosis/Hemostasis1938-27232021-01-012710.1177/1076029620984546Endothelial Function in Patients With Von Willebrand DiseaseStephanie Noone MD0Ralf Schubert MSc, PhD1Stephan Fichtlscherer MD, PhD2Thomas Hilberg MD, PhD3Sonja Alesci MD4Wolfgang Miesbach MD, PhD5 Haemostaseology, Department of Internal Medicine II, Institute of Transfusion Medicine, University Hospital, Goethe University Frankfurt am Main, Frankfurt, Germany Department for Children and Adolescents Medicine, University Hospital Frankfurt, Frankfurt am Main, Germany Division of Cardiology, Department of Internal Medicine III, University Hospital Frankfurt, Frankfurt am Main, Germany Department of Sports Medicine, University of Wuppertal, Wuppertal, Germany IMD Blood Coagulation Centre, Bad Homburg, Germany Haemostaseology, Department of Internal Medicine II, Institute of Transfusion Medicine, University Hospital, Goethe University Frankfurt am Main, Frankfurt, GermanyIn patients with von Willebrand disease (vWD) the interest in age-related comorbidities has grown, because the life expectancy of these patients has increased. The research question of this study was whether patients with vWD show a different endothelial function compared to the general population. A total of 37 patients with type 1 (n = 23), type 2 (n = 10) and type 3 (n = 4) vWD, 14 controls and 38 patients with coronary artery disease (CAD) were included in this study. Five markers of endothelial dysfunction (MOED) were determined. Moreover, the endothelial function was examined using the Itamar Endo-PAT. The reactive hyperemia index (RHI) was calculated from the results. The markers soluble intercellular adhesion molecule-1 (p = 0.171), P-Selectin (p = 0.512), interleukin-6 (p = 0.734) and monocyte chemoattractant protein-1 (p = 0.761) showed higher levels in patients with vWD, but were not significantly different compared to the control group. RHI was impaired in CAD-patients (1.855), whereas vWD patients had mean results of 1.870 and controls 2.112 (p = 0.367). In this study, the endothelial function measurements of patients with von Willebrand disease were not significantly different compared to healthy controls.https://doi.org/10.1177/1076029620984546 |
| spellingShingle | Stephanie Noone MD Ralf Schubert MSc, PhD Stephan Fichtlscherer MD, PhD Thomas Hilberg MD, PhD Sonja Alesci MD Wolfgang Miesbach MD, PhD Endothelial Function in Patients With Von Willebrand Disease Clinical and Applied Thrombosis/Hemostasis |
| title | Endothelial Function in Patients With Von Willebrand Disease |
| title_full | Endothelial Function in Patients With Von Willebrand Disease |
| title_fullStr | Endothelial Function in Patients With Von Willebrand Disease |
| title_full_unstemmed | Endothelial Function in Patients With Von Willebrand Disease |
| title_short | Endothelial Function in Patients With Von Willebrand Disease |
| title_sort | endothelial function in patients with von willebrand disease |
| url | https://doi.org/10.1177/1076029620984546 |
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