Regulatory NK cells in autoimmune disease
NK cells are defined as the major components of the immunological network which exerts defense against tumors and viral infections as well as regulation of innate and adaptive immunity, shaped through interaction with other cells like T cells. According to the surface markers, NK cells can be divide...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2023-06-01
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| Series: | Iranian Journal of Basic Medical Sciences |
| Subjects: | |
| Online Access: | https://ijbms.mums.ac.ir/article_22003_891c3d85b843623b66019c7acc551b85.pdf |
| _version_ | 1797682755341910016 |
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| author | Davood Bahadorian Samaneh Mollazadeh Hosein Mirazi Tola Faraj Ramiar Kheder Seyed-Alireza Esmaeili |
| author_facet | Davood Bahadorian Samaneh Mollazadeh Hosein Mirazi Tola Faraj Ramiar Kheder Seyed-Alireza Esmaeili |
| author_sort | Davood Bahadorian |
| collection | DOAJ |
| description | NK cells are defined as the major components of the immunological network which exerts defense against tumors and viral infections as well as regulation of innate and adaptive immunity, shaped through interaction with other cells like T cells. According to the surface markers, NK cells can be divided into CD56dim NK and CD56bright NK subsets. CD56bright NK cells usually are known as regulatory NK cells. Once the immune system loses its self-tolerance, autoimmune diseases develop. NK cells and their subsets can be altered during autoimmune diseases, indicative of their prominent regulatory roles and even pathological and protective functions in autoimmune disorders. In this regard, activation of CD56bright NK cells can suppress activated autologous CD4+ T cells and subsequently prevent the initiation of autoimmunity. In this review article, we summarize the roles of regulatory NK cells in autoimmune disease occurrence which needs more research to uncover their exact related mechanism. It seems that targeting NK cells can be a promising therapeutic platform against autoimmune diseases. |
| first_indexed | 2024-03-12T00:04:30Z |
| format | Article |
| id | doaj.art-bc49ce399b9a413cb236e243b3003a75 |
| institution | Directory Open Access Journal |
| issn | 2008-3866 2008-3874 |
| language | English |
| last_indexed | 2024-03-12T00:04:30Z |
| publishDate | 2023-06-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Basic Medical Sciences |
| spelling | doaj.art-bc49ce399b9a413cb236e243b3003a752023-09-17T06:20:28ZengMashhad University of Medical SciencesIranian Journal of Basic Medical Sciences2008-38662008-38742023-06-0126660961610.22038/ijbms.2023.68653.1496922003Regulatory NK cells in autoimmune diseaseDavood Bahadorian0Samaneh Mollazadeh1Hosein Mirazi2Tola Faraj3Ramiar Kheder4Seyed-Alireza Esmaeili5Immunology Research Center, Mashhad University of Medical Sciences, Mashhad, IranNatural Products and Medicinal Plants Research Center, North Khorasan University of Medical Sciences, Bojnurd, IranDepartment of Biomedical Engineering, Faculty of New Sciences and Technology, University of Tehran, Tehran, IranDepartment of Basic Sciences, College of Medicine, Hawler Medical University, Erbil, IraqMedical Laboratory Science Department, College of Science, University of Raparin, Rania, Sulaymaniyah, IraqImmunology Research Center, Mashhad University of Medical Sciences, Mashhad, IranNK cells are defined as the major components of the immunological network which exerts defense against tumors and viral infections as well as regulation of innate and adaptive immunity, shaped through interaction with other cells like T cells. According to the surface markers, NK cells can be divided into CD56dim NK and CD56bright NK subsets. CD56bright NK cells usually are known as regulatory NK cells. Once the immune system loses its self-tolerance, autoimmune diseases develop. NK cells and their subsets can be altered during autoimmune diseases, indicative of their prominent regulatory roles and even pathological and protective functions in autoimmune disorders. In this regard, activation of CD56bright NK cells can suppress activated autologous CD4+ T cells and subsequently prevent the initiation of autoimmunity. In this review article, we summarize the roles of regulatory NK cells in autoimmune disease occurrence which needs more research to uncover their exact related mechanism. It seems that targeting NK cells can be a promising therapeutic platform against autoimmune diseases.https://ijbms.mums.ac.ir/article_22003_891c3d85b843623b66019c7acc551b85.pdfautoimmune diseasecd56bright nk cellcytokineimmunologyregulatory nk cell |
| spellingShingle | Davood Bahadorian Samaneh Mollazadeh Hosein Mirazi Tola Faraj Ramiar Kheder Seyed-Alireza Esmaeili Regulatory NK cells in autoimmune disease Iranian Journal of Basic Medical Sciences autoimmune disease cd56bright nk cell cytokine immunology regulatory nk cell |
| title | Regulatory NK cells in autoimmune disease |
| title_full | Regulatory NK cells in autoimmune disease |
| title_fullStr | Regulatory NK cells in autoimmune disease |
| title_full_unstemmed | Regulatory NK cells in autoimmune disease |
| title_short | Regulatory NK cells in autoimmune disease |
| title_sort | regulatory nk cells in autoimmune disease |
| topic | autoimmune disease cd56bright nk cell cytokine immunology regulatory nk cell |
| url | https://ijbms.mums.ac.ir/article_22003_891c3d85b843623b66019c7acc551b85.pdf |
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