The Induction Mechanism of Ferroptosis, Necroptosis, and Pyroptosis in Inflammatory Bowel Disease, Colorectal Cancer, and Intestinal Injury
Cell death includes programmed and nonprogrammed cell death. The former mainly includes ferroptosis, necroptosis, pyroptosis, autophagy, and apoptosis, while the latter refers to necrosis. Accumulating evidence shows that ferroptosis, necroptosis, and pyroptosis play essential regulatory roles in th...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-05-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/13/5/820 |
| _version_ | 1797600876310822912 |
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| author | Ping Zhou Shun Zhang Maohua Wang Jun Zhou |
| author_facet | Ping Zhou Shun Zhang Maohua Wang Jun Zhou |
| author_sort | Ping Zhou |
| collection | DOAJ |
| description | Cell death includes programmed and nonprogrammed cell death. The former mainly includes ferroptosis, necroptosis, pyroptosis, autophagy, and apoptosis, while the latter refers to necrosis. Accumulating evidence shows that ferroptosis, necroptosis, and pyroptosis play essential regulatory roles in the development of intestinal diseases. In recent years, the incidence of inflammatory bowel disease (IBD), colorectal cancer (CRC), and intestinal injury induced by intestinal ischemia–reperfusion (I/R), sepsis, and radiation have gradually increased, posing a significant threat to human health. The advancement in targeted therapies for intestinal diseases based on ferroptosis, necroptosis, and pyroptosis provides new strategies for treating intestinal diseases. Herein, we review ferroptosis, necroptosis, and pyroptosis with respect to intestinal disease regulation and highlight the underlying molecular mechanisms for potential therapeutic applications. |
| first_indexed | 2024-03-11T03:55:04Z |
| format | Article |
| id | doaj.art-bc4c28cfbf304055b59a38451b9264e5 |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-11T03:55:04Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-bc4c28cfbf304055b59a38451b9264e52023-11-18T00:39:42ZengMDPI AGBiomolecules2218-273X2023-05-0113582010.3390/biom13050820The Induction Mechanism of Ferroptosis, Necroptosis, and Pyroptosis in Inflammatory Bowel Disease, Colorectal Cancer, and Intestinal InjuryPing Zhou0Shun Zhang1Maohua Wang2Jun Zhou3Department of Anesthesiology, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, ChinaDepartment of Anesthesiology, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, ChinaDepartment of Anesthesiology, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, ChinaDepartment of Anesthesiology, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, ChinaCell death includes programmed and nonprogrammed cell death. The former mainly includes ferroptosis, necroptosis, pyroptosis, autophagy, and apoptosis, while the latter refers to necrosis. Accumulating evidence shows that ferroptosis, necroptosis, and pyroptosis play essential regulatory roles in the development of intestinal diseases. In recent years, the incidence of inflammatory bowel disease (IBD), colorectal cancer (CRC), and intestinal injury induced by intestinal ischemia–reperfusion (I/R), sepsis, and radiation have gradually increased, posing a significant threat to human health. The advancement in targeted therapies for intestinal diseases based on ferroptosis, necroptosis, and pyroptosis provides new strategies for treating intestinal diseases. Herein, we review ferroptosis, necroptosis, and pyroptosis with respect to intestinal disease regulation and highlight the underlying molecular mechanisms for potential therapeutic applications.https://www.mdpi.com/2218-273X/13/5/820ferroptosisnecroptosispyroptosisinflammatory bowel diseasecolorectal cancerintestinal injury |
| spellingShingle | Ping Zhou Shun Zhang Maohua Wang Jun Zhou The Induction Mechanism of Ferroptosis, Necroptosis, and Pyroptosis in Inflammatory Bowel Disease, Colorectal Cancer, and Intestinal Injury Biomolecules ferroptosis necroptosis pyroptosis inflammatory bowel disease colorectal cancer intestinal injury |
| title | The Induction Mechanism of Ferroptosis, Necroptosis, and Pyroptosis in Inflammatory Bowel Disease, Colorectal Cancer, and Intestinal Injury |
| title_full | The Induction Mechanism of Ferroptosis, Necroptosis, and Pyroptosis in Inflammatory Bowel Disease, Colorectal Cancer, and Intestinal Injury |
| title_fullStr | The Induction Mechanism of Ferroptosis, Necroptosis, and Pyroptosis in Inflammatory Bowel Disease, Colorectal Cancer, and Intestinal Injury |
| title_full_unstemmed | The Induction Mechanism of Ferroptosis, Necroptosis, and Pyroptosis in Inflammatory Bowel Disease, Colorectal Cancer, and Intestinal Injury |
| title_short | The Induction Mechanism of Ferroptosis, Necroptosis, and Pyroptosis in Inflammatory Bowel Disease, Colorectal Cancer, and Intestinal Injury |
| title_sort | induction mechanism of ferroptosis necroptosis and pyroptosis in inflammatory bowel disease colorectal cancer and intestinal injury |
| topic | ferroptosis necroptosis pyroptosis inflammatory bowel disease colorectal cancer intestinal injury |
| url | https://www.mdpi.com/2218-273X/13/5/820 |
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