Education and risk of cancer in a large cohort of men and women in the United States.
<h4>Background</h4>Education inequalities in cancer incidence have long been noted. It is not clear, however, whether such inequalities persist in the United States, especially for less common malignancies and after adjustment for individual risk factors.<h4>Methodology/principal f...
| Autores principales: | , , , , , , |
|---|---|
| Formato: | Artículo |
| Lenguaje: | English |
| Publicado: |
Public Library of Science (PLoS)
2008-01-01
|
| Colección: | PLoS ONE |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/18982064/pdf/?tool=EBI |
| _version_ | 1831524160649560064 |
|---|---|
| author | Traci Mouw Annemarie Koster Margaret E Wright Madeleine M Blank Steven C Moore Albert Hollenbeck Arthur Schatzkin |
| author_facet | Traci Mouw Annemarie Koster Margaret E Wright Madeleine M Blank Steven C Moore Albert Hollenbeck Arthur Schatzkin |
| author_sort | Traci Mouw |
| collection | DOAJ |
| description | <h4>Background</h4>Education inequalities in cancer incidence have long been noted. It is not clear, however, whether such inequalities persist in the United States, especially for less common malignancies and after adjustment for individual risk factors.<h4>Methodology/principal findings</h4>Within the NIH-AARP Diet and Health Study, we examined the association between education and the risk of developing cancers in a prospective cohort of 498,455 participants who were 50-71 year old and without cancer at enrollment in 1995/96. During a maximum 8.2 years of follow-up we identified 40,443 cancers in men and 18,367 in women. In age-adjusted models, the least educated men (<high school), compared to those with the most education (post-graduate), had increased risks of developing cancers of the esophagus (RR: 2.64, 95%CI:1.86-3.75), head and neck (1.98, 1.54-2.54), stomach (2.32, 1.68-3.18), colon (1.31, 1.12-1. 53), rectum (1.68, 1.32-2.13), liver (1.90, 1.22-2.95), lung (3.67, 3.25-4.15), pleura (4.01, 1.91-8.42), bladder (1.56,1.33-1.83) and combined smoking-related cancers (2.41, 2.22-2.62). In contrast, lower education level was associated with a decreased risk of melanoma of the skin (0.43, 0.35-0.54) and local prostate cancers (0.79, 0.74-0.85). Women with the least education had increased risks of colon (1.60, 1.24-2.05), lung (2.14, 1.79-2.56), kidney (1.68, 1.12-2.54) and combined smoking-related cancers (1.66, 1.43-1.92) but a lower risk of melanoma of the skin (0.33, 0.22-0.51), endometrial (0.67, 0.51-0.89) and invasive breast cancers (0.72, 0.61-0.84). Adjustment for smoking and other risk factors did not eliminate these associations, except those for cancers of the head and neck, colon, and liver in men and kidney in women.<h4>Conclusions/significance</h4>We found a higher risk of malignant disease, particularly smoking- related cancers, among those in the lowest educational attainment category. Only some of the educational gradient is attributable to smoking. The persistence of substantial education inequalities in cancer incidence poses a challenge for etiologic research and public health policy. |
| first_indexed | 2024-12-16T08:57:55Z |
| format | Article |
| id | doaj.art-bc4e683f83bc44ebaf92466cacb4a37f |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-16T08:57:55Z |
| publishDate | 2008-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-bc4e683f83bc44ebaf92466cacb4a37f2022-12-21T22:37:15ZengPublic Library of Science (PLoS)PLoS ONE1932-62032008-01-01311e363910.1371/journal.pone.0003639Education and risk of cancer in a large cohort of men and women in the United States.Traci MouwAnnemarie KosterMargaret E WrightMadeleine M BlankSteven C MooreAlbert HollenbeckArthur Schatzkin<h4>Background</h4>Education inequalities in cancer incidence have long been noted. It is not clear, however, whether such inequalities persist in the United States, especially for less common malignancies and after adjustment for individual risk factors.<h4>Methodology/principal findings</h4>Within the NIH-AARP Diet and Health Study, we examined the association between education and the risk of developing cancers in a prospective cohort of 498,455 participants who were 50-71 year old and without cancer at enrollment in 1995/96. During a maximum 8.2 years of follow-up we identified 40,443 cancers in men and 18,367 in women. In age-adjusted models, the least educated men (<high school), compared to those with the most education (post-graduate), had increased risks of developing cancers of the esophagus (RR: 2.64, 95%CI:1.86-3.75), head and neck (1.98, 1.54-2.54), stomach (2.32, 1.68-3.18), colon (1.31, 1.12-1. 53), rectum (1.68, 1.32-2.13), liver (1.90, 1.22-2.95), lung (3.67, 3.25-4.15), pleura (4.01, 1.91-8.42), bladder (1.56,1.33-1.83) and combined smoking-related cancers (2.41, 2.22-2.62). In contrast, lower education level was associated with a decreased risk of melanoma of the skin (0.43, 0.35-0.54) and local prostate cancers (0.79, 0.74-0.85). Women with the least education had increased risks of colon (1.60, 1.24-2.05), lung (2.14, 1.79-2.56), kidney (1.68, 1.12-2.54) and combined smoking-related cancers (1.66, 1.43-1.92) but a lower risk of melanoma of the skin (0.33, 0.22-0.51), endometrial (0.67, 0.51-0.89) and invasive breast cancers (0.72, 0.61-0.84). Adjustment for smoking and other risk factors did not eliminate these associations, except those for cancers of the head and neck, colon, and liver in men and kidney in women.<h4>Conclusions/significance</h4>We found a higher risk of malignant disease, particularly smoking- related cancers, among those in the lowest educational attainment category. Only some of the educational gradient is attributable to smoking. The persistence of substantial education inequalities in cancer incidence poses a challenge for etiologic research and public health policy.https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/18982064/pdf/?tool=EBI |
| spellingShingle | Traci Mouw Annemarie Koster Margaret E Wright Madeleine M Blank Steven C Moore Albert Hollenbeck Arthur Schatzkin Education and risk of cancer in a large cohort of men and women in the United States. PLoS ONE |
| title | Education and risk of cancer in a large cohort of men and women in the United States. |
| title_full | Education and risk of cancer in a large cohort of men and women in the United States. |
| title_fullStr | Education and risk of cancer in a large cohort of men and women in the United States. |
| title_full_unstemmed | Education and risk of cancer in a large cohort of men and women in the United States. |
| title_short | Education and risk of cancer in a large cohort of men and women in the United States. |
| title_sort | education and risk of cancer in a large cohort of men and women in the united states |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/18982064/pdf/?tool=EBI |
| work_keys_str_mv | AT tracimouw educationandriskofcancerinalargecohortofmenandwomenintheunitedstates AT annemariekoster educationandriskofcancerinalargecohortofmenandwomenintheunitedstates AT margaretewright educationandriskofcancerinalargecohortofmenandwomenintheunitedstates AT madeleinemblank educationandriskofcancerinalargecohortofmenandwomenintheunitedstates AT stevencmoore educationandriskofcancerinalargecohortofmenandwomenintheunitedstates AT alberthollenbeck educationandriskofcancerinalargecohortofmenandwomenintheunitedstates AT arthurschatzkin educationandriskofcancerinalargecohortofmenandwomenintheunitedstates |